Computer-based design of sensors that can monitor endogenous Ras activity

Many questions on the activity of the Ras proto-oncogene are unanswered due to the lack of tools for detecting active Ras in living cells. Here, we used protein design and structure prediction algorithms to develop biosensors that detect the activity and environment of endogenous Ras.

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Fig. 1: Design of Ras sensors.

References

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This is a summary of: Zhang, J. Z. et al. Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02107-w (2024).