Ordinary Fruits, Extraordinary Benefits: Naturally Occurring Substance in Pomegranates Can Improve Alzheimer’s Symptoms

By University of Copenhagen – The Faculty of Health and Medical Sciences May 28, 2024

A new study from the University of Copenhagen has found that urolithin A, a compound found in pomegranates, strawberries, and walnuts, can improve memory and potentially treat Alzheimer’s disease symptoms. While the research, initially conducted on mouse models, shows that urolithin A can effectively remove damaged mitochondria from the brain, human clinical trials are upcoming.

A substance naturally occurring in i.e. pomegranates, strawberries, and walnuts can improve memory and treatment of Alzheimer’s disease, a new study conducted at the University of Copenhagen concludes.

Forgetfulness, difficulty finding words, and confusion about time and place are all common symptoms of Alzheimer’s disease.

Now researchers at the University of Copenhagen have discovered that an ordinary fruit can help.

“Our study on mouse models with AD shows that urolithin A, which is a naturally occurring substance in i.a. pomegranates, can alleviate memory problems and other consequences of dementia,” says Vilhelm Bohr, who is an Affiliate Professor at the Department of Cellular and Molecular Medicine at the University of Copenhagen and previously Department Chair at the US National Institute on Aging.

This is good news for patients with dementia – a disease that is difficult to treat.

“Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the muscles, and clinical trials on humans are being planned.”

Substance improves brain function

The researchers previously discovered that a specific molecule, nicotinamide riboside (NAD supplement), plays a key role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, as it actively helps remove damaged mitochondria from the brain.

“Many patients with neurodegenerative diseases experience mitochondrial dysfunction, also known as mitophagy. This means that the brain has difficulties removing weak mitochondria, which thus accumulate and affect brain function. If you are able to stimulate the mitophagy process, removing weak mitochondria, you will see some very positive results,” Vilhelm Bohr explains.

The results of the new study show that a substance found in pomegranates, urolithin A, removes weak mitochondria from the brain just as effectively as NAD supplements.

Possible preventive effect

The researchers still don’t know how much urolithin A is needed to improve memory and alleviate symptoms of i.a. Alzheimer’s.

“We still cannot say anything conclusive about the dosage. But I imagine that it is more than a pomegranate a day. However, the substance is already available in pill form, and we are currently trying to find the right dosage,” Vilhelm Bohr says.

He also hopes the substance can be used for preventive purposes with no significant side effects.

“The advantage of working with a natural substance is the reduced risk of side effects. Several studies so far show that there are no serious side effects of NAD supplementation. Our knowledge of urolithin A is more limited, but as I mentioned, clinical trials with Urolithin A have been effective in muscular disease, and now we need to look at Alzheimer’s disease,” he says.

He adds: “If we are going to eat something in the future to reduce the risk of Alzheimer’s, which we talk a lot about, we have to make sure there are no significant side effects.”

Reference: “Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions” by Yujun Hou, Xixia Chu, Jae-Hyeon Park, Qing Zhu, Mansoor Hussain, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Wei, Yue Wang, Evandro F. Fang, Deborah L. Croteau and Vilhelm A. Bohr, 16 May 2024, Alzheimer’s & Dementia.
DOI: 10.1002/alz.13847

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