Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity.
In cancer immunotherapy, stimulation of antitumor T cell responses requires recognition between T cell receptors and tumor-derived epitopes presented by the major histocompatibility complex class I (MHC-I)2. However, tumors with a low mutational burden have few neoantigens, which limits the repertoire of antitumor T cells3. Bacteria may enter both tumor cells and antigen-presenting cells in tumor tissues4, suggesting that microbial neoepitopes might engage antitumor T cell immunity, and several studies have reported that microbial peptide antigens can be presented by human tumor cells and can activate T cells ex vivo5,6. However, it has been difficult to exploit this phenomenon for cancer therapy.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
24,99 € / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
209,00 € per year
only 17,42 € per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Log in
Learn about institutional subscriptions
Read our FAQs
Contact customer support
Fig. 1: Antibiotics-loaded liposomes kill intratumoral bacteria and elicit antitumor T cell immunity.
References
Wang, M. L. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01957-8 (2023).
Article
PubMed
PubMed Central
Google Scholar
Kuai, R., Ochyl, L. J., Bahjat, K. S., Schwendeman, A. & Moon, J. J. Nat. Mater. 16, 489–496 (2017).
Article
CAS
Google Scholar
Zamora, A. E., Crawford, J. C. & Thomas, P. G. J. Immunol. 200, 392–399 (2018).
Article
CAS
PubMed
Google Scholar
Galeano Niño, J. L. et al. Nature 611, 810–817 (2022).
Article
PubMed
PubMed Central
Google Scholar
Kalaora, S. et al. Nature 592, 138–143 (2021).
Article
CAS
PubMed
PubMed Central
Google Scholar
Naghavian, R. et al. Nature 617, 807–817 (2023).
Article
CAS
PubMed
PubMed Central
Google Scholar
Nejman, D. et al. Science 368, 973–980 (2020).
Article
CAS
PubMed
PubMed Central
Google Scholar
Seynhaeve, A. L. B., Amin, M., Haemmerich, D., van Rhoon, G. C. & Ten Hagen, T. L. M. Adv. Drug Deliv. Rev. 163-164, 125–144 (2020).
Article
CAS
PubMed
Google Scholar
Riquelme, E. et al. Cell 178, 795–806.e12 (2019).
Article
CAS
PubMed
PubMed Central
Google Scholar
Download references
Author information
Author notes
These authors contributed equally: Kai Han, Young Seok Cho.
Authors and Affiliations
Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA
Kai Han, Young Seok Cho & James J. Moon
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China
Kai Han
Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA
Kai Han, Young Seok Cho & James J. Moon
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
James J. Moon
Corresponding author
Ethics declarations
Competing interests
J.J.M. declares financial interests for board membership, as a paid consultant, for research funding, and/or as an equity holder in EVOQ Therapeutics and Saros Therapeutics.
About this article
Cite this article
Han, K., Cho, Y.S. & Moon, J.J. Antibiotic nanoparticles boost antitumor immunity.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02046-6
Download citation
Published: 16 November 2023
DOI: https://doi.org/10.1038/s41587-023-02046-6
>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Nature.com – https://www.nature.com/articles/s41587-023-02046-6
