* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, July 15, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

    Kehoe repeals paid sick leave, allows several counties in the Ozarks to have entertainment districts in bill signings – KY3

    Kehoe repeals paid sick leave, allows several counties in the Ozarks to have entertainment districts in bill signings – KY3

    Emily Deschanel was scolded during “Bones” season 1 for being ‘late and unprepared’: ‘I was just beside myself’ – Yahoo

    Emily Deschanel was scolded during “Bones” season 1 for being ‘late and unprepared’: ‘I was just beside myself’ – Yahoo

    How you can see new movies early – Yahoo

    Unlock the Secret to Watching New Movies Before Everyone Else!

    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Guest columnist: China cutting corners on technology – The State Journal

    How China’s Technology Advances Are Raising Concerns Over Cutting Corners

    Sentrycs’ Cyber Over RF technology integrated into Rafael’s combat-proven Drone Dome system – Defence Industry Europe

    Sentrycs’ Cyber Over RF Technology Boosts Rafael’s Battle-Tested Drone Dome System

    Nordic Air Defence raises $3 million to expand operations and advance drone defence technology – Defence Industry Europe

    Nordic Air Defence Lands $3 Million to Transform Drone Defense and Supercharge Operations

    China’s energy dominance in three charts – MIT Technology Review

    How China Is Powering Its Energy Dominance: A Visual Breakdown

    Meta Acquires AI Startup PlayAI to Enhance Voice Technology Capa – GuruFocus

    Meta Acquires AI Startup PlayAI to Revolutionize Voice Technology Capabilities

    Stallion Uranium Provides Update on Technology Data Acquisition Agreement – GlobeNewswire

    Stallion Uranium Announces Exciting Progress in Technology Data Acquisition Agreement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

    Kehoe repeals paid sick leave, allows several counties in the Ozarks to have entertainment districts in bill signings – KY3

    Kehoe repeals paid sick leave, allows several counties in the Ozarks to have entertainment districts in bill signings – KY3

    Emily Deschanel was scolded during “Bones” season 1 for being ‘late and unprepared’: ‘I was just beside myself’ – Yahoo

    Emily Deschanel was scolded during “Bones” season 1 for being ‘late and unprepared’: ‘I was just beside myself’ – Yahoo

    How you can see new movies early – Yahoo

    Unlock the Secret to Watching New Movies Before Everyone Else!

    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Guest columnist: China cutting corners on technology – The State Journal

    How China’s Technology Advances Are Raising Concerns Over Cutting Corners

    Sentrycs’ Cyber Over RF technology integrated into Rafael’s combat-proven Drone Dome system – Defence Industry Europe

    Sentrycs’ Cyber Over RF Technology Boosts Rafael’s Battle-Tested Drone Dome System

    Nordic Air Defence raises $3 million to expand operations and advance drone defence technology – Defence Industry Europe

    Nordic Air Defence Lands $3 Million to Transform Drone Defense and Supercharge Operations

    China’s energy dominance in three charts – MIT Technology Review

    How China Is Powering Its Energy Dominance: A Visual Breakdown

    Meta Acquires AI Startup PlayAI to Enhance Voice Technology Capa – GuruFocus

    Meta Acquires AI Startup PlayAI to Revolutionize Voice Technology Capabilities

    Stallion Uranium Provides Update on Technology Data Acquisition Agreement – GlobeNewswire

    Stallion Uranium Announces Exciting Progress in Technology Data Acquisition Agreement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Microglia’s Key Function in Brain Development Uncovered

November 20, 2023
in Science
Microglia’s Key Function in Brain Development Uncovered
Share on FacebookShare on Twitter

By Agency for Science, Technology and Research (A*STAR), Singapore
November 19, 2023

Brain Organoid Petri Dish Art Concept

Researchers have discovered the vital role of microglia in brain development by studying lab-grown brain organoids. The study, focusing on cholesterol regulation by microglia, offers new perspectives on brain growth and potential approaches to treating neurological disorders. (Artist’s concept of a lab grown mini brain organoid.)

Scientists have found that microglia play a crucial role in regulating the number of cells that become neurons in the brain, enhancing our understanding of brain development and disorders.

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that act as its dedicated defense team, in early human brain development. By incorporating microglia into lab-grown brain organoids, scientists were able to mimic the complex environment within the developing human brain to understand how microglia influence brain cell growth and development.

This research represents a significant leap forward in the development of human brain organoids and has the potential to significantly impact our understanding of brain development and disorders. The study, “iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer” was published on November 1, 2023, in the journal Nature.

Breakthrough in Organoid Research

To investigate microglia’s crucial role in early human brain development, scientists from A*STAR’s Singapore Immunology Network (SIgN) led by Professor Florent Ginhoux, utilized cutting-edge technology to create brain-like structures called organoids, also known as “mini-brains” in the laboratory. These brain organoids closely resemble the development of the human brain. However, previous models were lacking in microglia, a key component of early brain development.

Super-Resolution Image of Human Stem Cell-Derived Microglia Cells

Super-resolution image of human stem cell-derived Microglia cells with labeled mitochondria (yellow), nucleus (magenta), and actin filaments (cyan). These Microglia cells help in the maturation of neurons in human brain organoid models. Credit: A*STAR’s SIgN

To bridge this gap, A*STAR researchers designed a unique protocol to introduce microglia-like cells generated from the same human stem cells used to create the brain organoids. These introduced cells not only behaved like real microglia but also influenced the development of other brain cells within the organoids.

Proteomic Analysis and Cholesterol’s Role

A*STAR’s Institute of Molecular and Cell Biology (IMCB)’s Dr. Radoslaw Sobota and his team at the SingMass National Laboratory for Mass Spectrometry applied cutting edge quantitative proteomics approach to uncover changes in protein. Their analysis provided crucial insights into the protein composition of the organoids, further confirming the study’s findings.

What sets this study apart is the discovery of a unique pathway through which microglia interact with other brain cells. The study found that microglia play a crucial role in regulating cholesterol levels in the brain.The microglia-like cells were found to contain lipid droplets containing cholesterol, which were released and taken up by other developing brain cells in the organoids. This cholesterol exchange was shown to significantly enhance the growth and development of these brain cells, especially their progenitors.

The Importance of Cholesterol in the Brain

Cholesterol is abundant in the brain and constitutes about 25% of the body’s total cholesterol content. It is essential for the structure and function of neurons. Abnormal cholesterol metabolism has been linked to various neurological disorders, including Alzheimer’s and Parkinson’s Disease.

To investigate the roles of lipids in brain development and disease, researchers from the Department of Biochemistry at the Yong Loo Lin School of Medicine (NUS Medicine), led by Professor Markus Wenk, took on the crucial task of data acquisition, particularly in the field of lipidomics to draw valuable insights into the lipid composition and dynamics within the brain organoids containing microglia.

Insights into Brain Cell Growth and Development

Using this information, another team from the Department of Microbiology and Immunology at NUS Medicine and led by Associate Professor Veronique Angeli, found that cholesterol affects the growth and development of young brain cells in human brain models. Microglia use a specific protein to release cholesterol, and when this process is blocked, it causes the organoid cells to grow more, leading to larger brain models.

“It has always been known that the microglia is key to brain development, however their precise role remains poorly understood. This finding from our team at the Department of Microbiology and Immunology is particularly impactful because we finally understand how cholesterol is transported. Our next focus will be finding out how we can regulate cholesterol release to optimize brain development and slow down, or prevent, the onset of neurological conditions,” added Assoc Prof Veronique, who is also Director of the Immunology Translational Research Programme at NUS Medicine.

Comprehensive Analysis of Molecular Interactions

Dr. Olivier Cexus from the University of Surrey and formerly at A*STAR, progressively deciphered the complex molecular interactions within the brain organoids using proteomic and lipidomic analysis. This provided valuable insights into the metabolic cross-talks involved in brain development and potential implications for diseases.

Together, these collective efforts were instrumental in deepening our understanding of the roles of microglia and the molecular components within brain organoids and their implications for human health.

Conclusion and Future Implications

Prof Florent Ginhoux, Senior Principal Investigator at A*STAR’s SIgN and Senior author of the study said, “Understanding the complex roles of microglia in brain development and function is an active area of research. Our findings not only advance our understanding of human brain development but also have the potential to impact our knowledge of brain disorders. This opens up new possibilities for future research into neurodevelopmental conditions and potential therapies.”

Co-author of the study, Professor Jerry Chan, Senior Consultant, Department of Reproductive Medicine, KK Women’s and Children’s Hospital, and Senior National Medical Research Council Clinician Scientist, added, “There is currently a lack of tools to study how microglia interacts with the developing brain. This has hampered the understanding of microglia-associated diseases that play an important role during the early development of conditions such as autism, schizophrenia, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.

“The development of these novel microglia-associated brain organoids with same-donor pluripotent stem cells gives us an opportunity to study the complex interactions between microglia and neurons during early brain development. Consequentially, this may enable us to study the role of microglia in the setting of diseases and suggest ways to develop new therapies in time.”

Reference: “iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer” by Dong Shin Park, Tatsuya Kozaki, Satish Kumar Tiwari, Marco Moreira, Ahad Khalilnezhad, Federico Torta, Nicolas Olivié, Chung Hwee Thiam, Oniko Liani, Aymeric Silvin, Wint Wint Phoo, Liang Gao, Alexander Triebl, Wai Kin Tham, Leticia Gonçalves, Wan Ting Kong, Sethi Raman, Xiao Meng Zhang, Garett Dunsmore, Charles Antoine Dutertre, Salanne Lee, Jia Min Ong, Akhila Balachander, Shabnam Khalilnezhad, Josephine Lum, Kaibo Duan, Ze Ming Lim, Leonard Tan, Ivy Low, Kagistia Hana Utami, Xin Yi Yeo, Sylvaine Di Tommaso, Jean-William Dupuy, Balazs Varga, Ragnhildur Thora Karadottir, Mufeeda Changaramvally Madathummal, Isabelle Bonne, Benoit Malleret, Zainab Yasin Binte, Ngan Wei Da, Yingrou Tan, Wei Jie Wong, Jinqiu Zhang, Jinmiao Chen, Radoslaw M. Sobota, Shanshan W. Howland, Lai Guan Ng, Frédéric Saltel, David Castel, Jacques Grill, Veronique Minard, Salvatore Albani, Jerry K. Y. Chan, Morgane Sonia Thion, Sang Yong Jung, Markus R. Wenk, Mahmoud A. Pouladi, Claudia Pasqualini, Veronique Angeli, Olivier N. F. Cexus and Florent Ginhoux, 32 October 2023, Nature.
DOI: 10.1038/s41586-023-06713-1

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/microglias-key-function-in-brain-development-uncovered/

Tags: functionMicroglia’sscience
Previous Post

Nigeria’s passport server breaks down in U.S., application process suspended; Tinubu begged to intervene

Next Post

EMIT: NASA’s Unexpected Hero in the Climate Crisis

Guest columnist: China cutting corners on technology – The State Journal

How China’s Technology Advances Are Raising Concerns Over Cutting Corners

July 15, 2025
Fútbol fever: Students learn about sports management at Real Madrid – FIU News

Fútbol fever: Students learn about sports management at Real Madrid – FIU News

July 15, 2025
An ecological oasis sits in the center of San Juan Capistrano – Orange County Register

Uncover the Hidden Ecological Oasis at the Heart of San Juan Capistrano

July 15, 2025
Adorable Cat Helps Scientists Discover New Virus (For Second Time) – ScienceAlert

Adorable Cat Teams Up with Scientists to Uncover a New Virus-Again!

July 15, 2025
San Diego scientists try to unlock the secrets of cannabis – KPBS

San Diego Scientists Race to Unlock the Secrets of Cannabis

July 15, 2025
Lifestyle Lookout: NW Tune-Up, Bellingham PRIDE Parade, live music and more – My Bellingham Now

Get Ready for Exciting Events: NW Tune-Up, Bellingham PRIDE Parade, Live Music & More!

July 15, 2025
New York governor says World Cup prime target for drone attacks – Reuters

New York Governor Issues Stark Warning: World Cup at High Risk for Drone Attacks

July 15, 2025
Janet Yellen on the Danger of a “Banana Republic” Economy – The New Yorker

Janet Yellen Warns of the Risks Behind a “Banana Republic” Economy

July 15, 2025
Concert Will Celebrate Music Of Queen – CapeNews.net

Epic Concert to Celebrate the Timeless Music of Queen

July 15, 2025

How Your Age at Menarche Shapes Your Cardiometabolic and Reproductive Health Risks

July 15, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (722)
  • Economy (744)
  • Entertainment (21,631)
  • General (15,904)
  • Health (9,782)
  • Lifestyle (752)
  • News (22,149)
  • People (746)
  • Politics (755)
  • Science (15,963)
  • Sports (21,243)
  • Technology (15,729)
  • World (728)

Recent News

Guest columnist: China cutting corners on technology – The State Journal

How China’s Technology Advances Are Raising Concerns Over Cutting Corners

July 15, 2025
Fútbol fever: Students learn about sports management at Real Madrid – FIU News

Fútbol fever: Students learn about sports management at Real Madrid – FIU News

July 15, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version