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A New Generation of Drug Therapies Requires New Business Strategies

February 28, 2024
in Business
A New Generation of Drug Therapies Requires New Business Strategies
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The shift toward advanced therapeutic modalities will require life sciences companies to rethink strategy, investments, and risk management.

February 27, 2024

Luis Alvarez/Getty Images

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The shift to advanced therapeutic modalities (ATMs) promises to change the nature of competition in the pharmaceuticals industry. ATMs include engineered cell therapies that reprogram cells to fight disease, gene therapies that involve replacing or editing dysfunctional genes, and nucleic acid therapies that promote or shut down production of a protein. They are shifting the nature of drug R&D risk and establishing manufacturing as a critical strategic priority alongside therapeutic safety and efficacy while also introducing new commercialization challenges.

The life sciences industry is undergoing a fundamental evolution in how drugs are discovered, developed, and manufactured. The industry is shifting from traditional drug research and development techniques used for small molecules and antibodies to advanced therapeutic modalities (ATMs), a category that encompasses engineered cell therapies that reprogram cells to fight disease, gene therapies that involve replacing or editing dysfunctional genes, and nucleic acid therapies that promote or shut down production of a protein (e.g., the mRNA vaccines indicated for Covid-19 from Moderna and Pfizer/BioNTech).

Alex Vadas is a managing director and partner in L.E.K. Consulting’s Los Angeles office. He is a member of the firm’s Health Care practice and coleads the Life Sciences Enablers practice.

Jeff Holder is a managing director and partner in L.E.K. Consulting San Francisco office and is a member of the firm’s Life Sciences practice.

Adam Siebert is a managing director and partner in L.E.K. Consulting’s New York office and is a member of the firm’s Life Sciences practice.

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Copyright for syndicated content belongs to the linked Source : Harvard Business – https://hbr.org/2024/02/a-new-generation-of-drug-therapies-requires-new-business-strategies

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