* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, July 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

    Canes owner Tom Dundon’s real estate firm eyes entertainment complex near RDU – The Business Journals

    Canes Owner Tom Dundon’s Real Estate Firm Unveils Plans for Thrilling New Entertainment Complex Near RDU

    Inspired Entertainment, Inc.’s (NASDAQ:INSE) Price Is Right But Growth Is Lacking After Shares Rocket 29% – simplywall.st

    Inspired Entertainment Soars 29% but Growth Momentum Falls Short

    Kroger shares summer entertainment tips – Supermarket Perimeter

    Ultimate Summer Entertainment Tips to Make Your Season Unforgettable

    Theater at Santa Fe’s San Isidro Plaza will be converted into IMAX, family entertainment venue – Santa Fe New Mexican

    Santa Fe’s San Isidro Plaza Theater Transforms into Exciting IMAX Family Entertainment Venue

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

    Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

    Defence Holdings PLC Transitions from Esports to Pioneering Defence Technology

    Bull of the Day: Credo Technology Group (CRDO) – Yahoo Finance

    Bull of the Day: Why Credo Technology Group (CRDO) Is Poised for a Breakout

    BlackSky Technology Inc. Stock Analysis and Forecast – Explosive wealth accumulation – Jammu Links News

    BlackSky Technology Inc.: Unlocking Explosive Wealth Potential Through Expert Stock Analysis and Forecast

    Polypurine Hairpin Technology is Safe, Effective at Inhibiting PCSK9 to Regulate Cholesterol – Pharmacy Times

    Polypurine Hairpin Technology: A Safe and Powerful Breakthrough for Controlling Cholesterol by Targeting PCSK9

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

    Canes owner Tom Dundon’s real estate firm eyes entertainment complex near RDU – The Business Journals

    Canes Owner Tom Dundon’s Real Estate Firm Unveils Plans for Thrilling New Entertainment Complex Near RDU

    Inspired Entertainment, Inc.’s (NASDAQ:INSE) Price Is Right But Growth Is Lacking After Shares Rocket 29% – simplywall.st

    Inspired Entertainment Soars 29% but Growth Momentum Falls Short

    Kroger shares summer entertainment tips – Supermarket Perimeter

    Ultimate Summer Entertainment Tips to Make Your Season Unforgettable

    Theater at Santa Fe’s San Isidro Plaza will be converted into IMAX, family entertainment venue – Santa Fe New Mexican

    Santa Fe’s San Isidro Plaza Theater Transforms into Exciting IMAX Family Entertainment Venue

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

    Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

    Defence Holdings PLC Transitions from Esports to Pioneering Defence Technology

    Bull of the Day: Credo Technology Group (CRDO) – Yahoo Finance

    Bull of the Day: Why Credo Technology Group (CRDO) Is Poised for a Breakout

    BlackSky Technology Inc. Stock Analysis and Forecast – Explosive wealth accumulation – Jammu Links News

    BlackSky Technology Inc.: Unlocking Explosive Wealth Potential Through Expert Stock Analysis and Forecast

    Polypurine Hairpin Technology is Safe, Effective at Inhibiting PCSK9 to Regulate Cholesterol – Pharmacy Times

    Polypurine Hairpin Technology: A Safe and Powerful Breakthrough for Controlling Cholesterol by Targeting PCSK9

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Entertainment

‘A defining feature of stem cells is that they can become other cells’: Strategies for the use of stem cells in cultivated meat production

October 30, 2023
in Entertainment
‘A defining feature of stem cells is that they can become other cells’: Strategies for the use of stem cells in cultivated meat production
Share on FacebookShare on Twitter

A review in Nature Food ​explored the use of stem cells in cultivated meat, exploring the best stem cells for the job as well as potential barriers. 

Stem cells, according to the UK’s National Health Service, are the building blocks of life, basic cells that transform (differentiate) into other cells within its native organism. Thus, they provide a key opportunity for producers of cultivated meat, as they are flexible and can be used in a wide variety of ways.

Using stem cells that create the major cellular components of meat, such as myofibres, adipocytes and fibroblasts, is an efficient way for cultivated meat producers to proliferate their product, as well as effectively replicate the taste of slaughtered animal meat.

“A defining feature of stem cells is that they can become other cells​,” Lucas Robert Smith, one of the authors of the review, told FoodNavigator. “With beef, for example, the goal is to have cow stem cells that can turn into muscle or fat cells.  This will impact the proteins and fats present in the cells that impart flavour of meat as we know it​.”

Getting texture and fat​

When developing cultivated meat, it is important to replicate the texture of traditional animal meat (texture has been shown on many occasions to be a key consumer concern). “The texture of meat is complex and involves interactions between multiple cells,”​ Smith told us. “One of the critical components is the dominant extracellular matrix protein, collagen.​

“While many cells produce collagen in muscle fibroblasts, fibroadipogenic progenitors play the primary role in collagen production and in organizing the collagen in the ways that influence texture​.”

Fat is also a key component of cultivated meat. “In addition, fibroadipogenic progenitors can be differentiated into fat cells following adipogenic induction​,” Smith told us. “Intramuscular fat, also known as marbling fat in pork and beef, originate from these fibroadipogenic progenitors. Other potential cell sources for cell-cultured fat include adipose-derived stem cells and dedifferentiated mature adipocytes.  Both have strong adipogenic potential in vitro and can be readily differentiated into fat cells when grown in adipogenic media​.”

Proliferation ​

Of course, for stem cells to be efficient in the development of any quantities of cultivated meat, they need to be able to proliferate. While doubling is typical of stem cells, some cells are better at this than others.

“Cell doubling in a 24-hour timeframe is typical for cultured cells in a rich growth environment​,” Smith told us. “Embryonic stem cells divide rapidly during development and doubling times of 16-20 hours are feasible. There have been reports of mouse embryonic stem cells dividing every 4-5 hours while maintaining their pluripotency, ability to become any cell type. Creating culture conditions and cell lines that optimize doubling times while maintaining cell functions will be important for cultivated meat production​.”

When stem cells become immortalised, they are even more efficient at proliferating, as they can keep key qualities that stem cells have whilst doubling. “Immortalized stem cells can undergo indefinite doublings while maintaining their stem cell qualities to become other differentiated cell types such as muscle. Often, achieving 100 doublings is used as a practical way to assess if a cell is immortalized. There are a variety of methods of immortalization to accomplish this.​”

GettyImages-1401696114Stem cells can help the development of cultivated meat. Image Source: TopMicrobialStock/Getty Images

Researchers are still working on ways to immortalise stem cells, but there are a few barriers, Smith told us. “Cells have checkpoints before undergoing the cell cycle to duplicate themselves. One limiting factor is the telomeres at the end of chromosomes shorten at each doubling and limit the doubling potential. A strategy to combat this is to add telomere lengthening enzymes to the cells to bypass this limit. It is also possible to introduce signals to bypass the checkpoints for undergoing the cell cycle.  Another strategy is to put cells under stress that force a few cells to adapt, become immortal, and can then be selected​.”

Some of the best stem cells for proliferation also come with barriers to efficient production. Pluripotent stem cells (PSCs) can indefinitely renew and are able to become almost any cell type relevant to cultivated meat. They “resemble the cells found in the embryo during early stages of development​,” Smith told us.

However, while this “make(s) them a desirable source for cultivated meat, it also means more steps are necessary to produce specialized muscle or fat cells. At this moment, the efficient and consistent differentiation of PSCs into meat progenitor cells is still a barrier for the use of PSCs​.”

One of the potential ways of overcoming such hurdles presented by individual stem cells is genetic modification. “The cells used dictate the ability to proliferate, to determine cell type, as well as the media conditions necessary for each type.​ Genetically modifying stem cells has the potential to overcome each of those hurdles​,” Smith told us.

“Genetic modification can produce immortalized cells, control differentiation into muscle or fat components, and ability to grow without expensive media additives. However, further research is needed in order to make these possible using genetic engineering​.”

Differentiation and the ethics of FBS​

When stem cells differentiate, they develop into specific cells that serve a function within an animal organism. This process is vital for the development of cultivated meat.

One of the key aids to this is fetal bovine serum (FBS), as it provides cells with key nutrients and growth factors. However, FBS is sourced from cow foetuses (although these foetuses are not specifically slaughtered for FBS), challenging the vegan status of cultivated meat when it is used.

FBS “has been a critical component of cell culture media for many decades​,” Smith told us. “Its use has allowed scientists to make incredible advances in cell culture techniques and is the foundation of our current knowledge of how cells and tissues work.​

“While these advances permit us to contemplate making meat in the lab today, it is important we consider alternatives that use strategies that are free of animal components (except for the cells), and do not require or minimize animal slaughter.​

“FBS is an expensive component of growth media. There are serum replacement formulations in the cell culture market, however they are equally expensive. The field is actively looking into ways to culture cells without serum​.”

Regulation ​

Of course, the use of such technology will need to be regulated. Research at the cutting edge almost always presents risks, and cultivated meat developed through stem cells is no exception.

“For any food product, safety is the fundamental priority​,” Smith told us. “Although the manufacturing, processing, and preparation of cultivated meat is different from conventional meat, the risk-based food safety principles remain the same. ​

“Each company will need to establish science-based approaches to identify, characterize, and control microbial, chemical, and physical hazards of the manufacturing process. These control strategies will need to be validated, verified, and approved by regulatory agencies. In addition, nutritional claims and food labels of the product need to be truthful and not misleading​.”

Sourced From: Nature Food
‘Stem cell-based strategies and challenges for production of cultivated meat’
Published on: 16 October 2023
Doi: https://doi.org/10.1038/s43016-023-00857-z
Authors: T. C. Jara, K. Park, P. Vahmani, A. L. Van Eenennaam, L. R. Smith & A. C. Denicol

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : FoodNavigator – https://www.foodnavigator.com/Article/2023/10/30/stem-cells-strategies-for-their-use-in-cultivated-meat-production?utm_source=RSS_Feed&utm_medium=RSS&utm_campaign=RSS

Tags: Cellsdefiningentertainment
Previous Post

Bovaer pilot achieves up to 42% enteric methane reduction from dairy cows

Next Post

How cultivated meat could be the key to avoiding the development of antimicrobial resistance

Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

July 21, 2025
Sports Fans Saddened By Barron Trump’s Announcement – Yahoo Sports

Sports Fans Express Disappointment Over Barron Trump’s Announcement

July 21, 2025
Migrating shorebird killed by raptor at 3000 m above ground as revealed by high-resolution tracking – ESA Journals

Dramatic High-Altitude Encounter: Migrating Shorebird Taken Down by Raptor at 3000 Meters

July 21, 2025
One Dietary Supplement Shown to Reduce Aggression by Up to 28% – ScienceAlert

This Dietary Supplement Can Slash Aggression by Nearly 30%

July 21, 2025
Hundreds of NASA Employees Condemn Trump Administration Cuts in Public Letter – The New York Times

Hundreds of NASA Employees Unite in Powerful Open Letter Opposing Trump Administration Budget Cuts

July 21, 2025
JioHotstar taps influencers to turn Wimbledon into a lifestyle experience for India’s young consumers – MSN

How JioHotstar Is Turning Wimbledon into a Lifestyle Phenomenon for India’s Youth Through Influencers

July 21, 2025
Porsche CEO seeks fresh cost cuts, warning business model ‘no longer works’ in post-Trump, new China world – Fortune

Porsche CEO seeks fresh cost cuts, warning business model ‘no longer works’ in post-Trump, new China world – Fortune

July 21, 2025
The economy is turbulent for influencers, too — here’s how you might see it online – NPR

How Today’s Turbulent Economy Is Transforming the World of Influencers-and What It Means for Your Online Experience

July 21, 2025
Tom Troupe, prolific star of the stage and screen, is dead at 97 – Los Angeles Times

Legendary Stage and Screen Star Tom Troupe Passes Away at 97

July 21, 2025
Mayo’s Alzheimer’s blood test research, Baptist’s leadless pacemaker top Healthful News – The Florida Times-Union

Revolutionary Breakthroughs in Alzheimer’s Blood Tests and Leadless Pacemakers Transform Healthcare Forever

July 21, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (732)
  • Economy (755)
  • Entertainment (21,639)
  • General (16,025)
  • Health (9,793)
  • Lifestyle (763)
  • News (22,149)
  • People (757)
  • Politics (764)
  • Science (15,972)
  • Sports (21,253)
  • Technology (15,738)
  • World (738)

Recent News

Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

July 21, 2025
Sports Fans Saddened By Barron Trump’s Announcement – Yahoo Sports

Sports Fans Express Disappointment Over Barron Trump’s Announcement

July 21, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version