* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, October 9, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ENERCON and Biome collaborate for wind turbine noise reduction technology – Yahoo Finance

    ENERCON and Biome Join Forces to Revolutionize Wind Turbine Noise Reduction

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ENERCON and Biome collaborate for wind turbine noise reduction technology – Yahoo Finance

    ENERCON and Biome Join Forces to Revolutionize Wind Turbine Noise Reduction

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Entertainment

Early-life exposure to Great Chinese Famine linked to gut microbiome disruption, greater type 2 diabetes risk: Cohort study

January 3, 2024
in Entertainment
Early-life exposure to Great Chinese Famine linked to gut microbiome disruption, greater type 2 diabetes risk: Cohort study
Share on FacebookShare on Twitter

The Great Chinese Famine lasted from 1959 to 1961 during the leadership of Mao Tse Tung and was characterised by widespread food shortages and famine in China. The crisis was largely attributed to the implementation of radical agricultural and economic policies, such as the Great Leap Forward, which led to mass collectivisation and inefficiencies in farming practices. 

The combination of natural disasters, mismanagement and the focus on industrialisation over agriculture resulted in a severe food crisis. Estimates of the death toll vary but it is believed that tens of millions of people died as a result of starvation and related causes during this period.

A recent study, led by China’s Westlake University, delved into the intricate relationship between early-life famine exposure, alterations in the gut microbiome, and the subsequent risk of type 2 diabetes. Involving 11,513 participants, the study spanned three major independent Chinese cohorts — the Great Northern Han Chinese Health Study (GNHS), Great Green Mountain Project (GGMP) and the China Health and Nutrition Survey (CHNS).

Rigours of research​

The research, rooted in the Developmental Origins of Health and Disease (DOHaD) hypothesis, explored how adverse exposures during early life — particularly in utero — could markedly influence later-life health and disease status. Drawing on the context of the Great Chinese Famine, a natural experiment unfolded, providing a unique opportunity to investigate the long-term impact of early-life adverse exposure on gut microbiota and its role in DOHaD.

Participants, spanning 16 major provinces and megacities across China, underwent comprehensive examination of gut microbial diversity, community structure and keystone taxa. The primary focus was to investigate the association between early-life famine exposure and adult gut microbial alterations, with a secondary objective of assessing its link to type 2 diabetes.

Demographic and medication data were collected through face-to-face questionnaire interviews, encompassing crucial factors such as age, sex, date of birth, average household income, and medication use, including antibiotics, hypoglycaemic drugs and hypolipidemic drugs. Anthropometric measurements, blood samples and detailed metabolic data were also gathered, ensuring a comprehensive dataset.

Findings on the famished​

Participants were classified into various exposure groups based on their birth year, ranging from those born during the famine to those born before and after, providing a nuanced understanding of the impact of famine exposure during different life stages.

The gut microbiome analyses involved sequencing stool samples from each cohort in a single batch, which the researchers used to examine the variations in gut microbial composition among the three cohorts.

The study underscored the critical role of the gut microbiome in the DOHaD hypothesis, shedding light on the potential mechanisms linking early-life malnutrition to gut microbial dysbiosis in adults. At the same time, keystone taxa identified in the study were found to be crucial in influencing insulin resistance and metabolic health.

The researchers reported that famine exposure during the first 1,000 days of life was significantly associated with alterations in gut microbial alpha diversity, with consistently lower diversity observed across the cohorts.

They also identified specific keystone taxa that played a central role in the microbial ecosystem. These keystone taxa were not only associated with gut microbial alpha diversity but were also found to be disrupted in participants exposed to famine during the critical first 1,000 days of life. Furthermore, disturbances in the gut microbiome were found to be positively associated with the risk of type 2 diabetes.

The researchers stated: “Compared with the no-exposed control group (born during 1962 to 1964), participants who were exposed to the famine during the first 1,000 days of life (born in 1959) had consistently lower gut microbial alpha diversity and alterations in the gut microbial community during adulthood across the three cohorts.

“Compared with the no-exposed control group, participants who were exposed to famine during the first 1,000 days of life were associated with consistently lower levels of keystone taxa index in the three cohorts. Per 1-standard deviation increment in the keystone taxa index was associated with a 13% lower risk of type 2 diabetes, with consistent results across three individual cohorts.”

Breaking new ground​

While the study was the first to comprehensively examine the lifelong impact of early-life famine exposure on the adult gut microbiota, certain limitations, including potential bias due to the observational nature of the study and sample size constraints, were acknowledged. The findings, however, were consistent across diverse cohorts, bolstering their generalisability.

The study also signifies a paradigm shift in understanding the developmental origins of health and disease, highlighting the pivotal role of the gut microbiome. Additionally, the identified keystone taxa offered potential targets for interventions or therapeutics in addressing type 2 diabetes, with further investigations warranted to validate and elucidate the underlying mechanisms of these ground-breaking findings.

Source: BMC Medicine​

“​Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies​”​

https://doi.org/10.1186/s12916-023-03123-y​

Authors: Wanglong Gou, et al​.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : FoodNavigatorAsia – https://www.nutraingredients-asia.com/Article/2024/01/03/Early-life-exposure-to-Great-Chinese-Famine-linked-to-gut-microbiome-disruption-says-China-study?utm_source=RSS_Feed&utm_medium=RSS&utm_campaign=RSS

Tags: Early-lifeentertainmentexposure
Previous Post

Plant-based diets linked to lower gestational diabetes risk: Chinese meta-analysis

Next Post

Movers and shakers: Five must-know regulations and policies set to impact the APAC food and beverage sector in 2024

IRONMAN World Championship Kona 2025: Date, start time and how to watch live – TRI247

IRONMAN World Championship Kona 2025: Date, start time and how to watch live – TRI247

October 9, 2025
Canada’s economy is in serious trouble. Now Mark Carney is coming to Washington to talk tariffs – CNN

Canada’s economy is in serious trouble. Now Mark Carney is coming to Washington to talk tariffs – CNN

October 9, 2025
Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

October 9, 2025
Better Food, Better Health: Redefining Chronic Disease Care Through Nutrition – The American Journal of Managed Care® (AJMC®)

Better Food, Better Health: Redefining Chronic Disease Care Through Nutrition – The American Journal of Managed Care® (AJMC®)

October 9, 2025
WATCH: ‘Come and get me,’ Pritzker responds to Trump’s call to put Illinois governor in jail – PBS

WATCH: ‘Come and get me,’ Pritzker responds to Trump’s call to put Illinois governor in jail – PBS

October 9, 2025
New Method to Monitor Wild Reindeer Populations Could Boost Conservation Efforts – Bioengineer.org

New Method to Monitor Wild Reindeer Populations Could Boost Conservation Efforts – Bioengineer.org

October 8, 2025
Scientists just proved the moai could walk, solving a 500-year mystery – ScienceDaily

Scientists Finally Reveal How the Moai Statues Could “Walk,” Solving a 500-Year Mystery

October 8, 2025
GenoPalate Advances Its Science Again With Diet Snapshot – Yahoo Finance

GenoPalate Advances Its Science Again With Diet Snapshot – Yahoo Finance

October 8, 2025
Horses making the rounds at Florida hospitals – The Union Democrat

Horses Bringing Joy and Healing to Florida Hospitals

October 8, 2025
ENERCON and Biome collaborate for wind turbine noise reduction technology – Yahoo Finance

ENERCON and Biome Join Forces to Revolutionize Wind Turbine Noise Reduction

October 8, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (858)
  • Economy (879)
  • Entertainment (21,752)
  • General (17,490)
  • Health (9,921)
  • Lifestyle (891)
  • News (22,149)
  • People (880)
  • Politics (890)
  • Science (16,089)
  • Sports (21,379)
  • Technology (15,859)
  • World (862)

Recent News

IRONMAN World Championship Kona 2025: Date, start time and how to watch live – TRI247

IRONMAN World Championship Kona 2025: Date, start time and how to watch live – TRI247

October 9, 2025
Canada’s economy is in serious trouble. Now Mark Carney is coming to Washington to talk tariffs – CNN

Canada’s economy is in serious trouble. Now Mark Carney is coming to Washington to talk tariffs – CNN

October 9, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version