* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home General

Designer immune-cell therapy could shrink deadly brain tumors, early trials show

March 15, 2024
in General
Designer immune-cell therapy could shrink deadly brain tumors, early trials show
Share on FacebookShare on Twitter

Colored CT scan of a section through a person's brain with a glioblastoma shown in orange on the left side of the brain (shown at the top in this image as rotated 90 degrees)

Glioblastomas are the most aggressive form of brain cancer. An example of one of these tumors is shown in the colored brain scan image above in orange.
(Image credit: DR P. MARAZZI/SCIENCE PHOTO LIBRARY via Getty Images)

A new immune cell-based treatment for glioblastoma, the most aggressive type of brain cancer, has shown promise in shrinking tumors in the short-term, according to two early clinical trials. 

The trials tested the safety and effectiveness of a personalized therapy called chimeric antigen receptor (CAR) T-cell therapy. This involves drawing out and genetically manipulating patients’ immune cells, known as T cells, to more effectively recognize and attack tumors once they’re reintroduced into the body. 

One of the trials, described in a paper published Wednesday (March 13) in the New England Journal of Medicine (NEJM), included three patients with recurrent glioblastoma, meaning their cancer had returned following standard radiation and chemotherapy. T cells from these patients were genetically modified to target two versions of a receptor called epidermal growth factor receptor (EGFR) on the surface of tumor cells. 

In the second trial, published the same day in the journal Nature Medicine, researchers used CAR T cells to target EGFR and an additional tumor-related receptor, called interleukin-13 receptor alpha 2, in six patients with recurrent glioblastoma.  

Related: In a 1st, scientists use designer immune cells to send an autoimmune disease into remission

Both trials found that CART-cell therapy was safe and reduced tumor size in all nine patients. In the Nature Medicine study, patients saw these reductions within one or two days, while in the NEJM study they saw them after one to five days. One NEJM patient’s tumor almost completely regressed five days after a single treatment, while another person’s tumor decreased in size by 60.7% after 69 days.

However, these effects didn’t necessarily last. Tumors returned for two patients in the NEJM study, within either 72 days or a month after the initial infusion. The other patient showed no signs of tumor recurrence more than 150 days after treatment, although this was the last assessment point of the study so it is uncertain whether this occurred afterward. Some of the reductions seen in the Nature Medicine study have also been sustained for several months, for example up to seven months in one patient. 

Glioblastomas are notoriously difficult to treat, usually relying on surgery to remove them as well as chemotherapy and radiation to kill the cancerous cells. Each year, more than 10,000 people in the U.S. are diagnosed with glioblastoma. Only 6.9% of them survive beyond five years after diagnosis and most live for only another eight months. 

Medical illustration of two cancer cells in purple against a black background. One of the cancer cells (on the right) is being attacked by a T cell, in gold

CAR-T therapy is an immunotherapy which involves reprogramming T cells to better attack tumors. In the illustration above, a T cell, in brown, can be seen attacking cancer cells, in purple. (Image credit: THOM LEACH / SCIENCE PHOTO LIBRARY via Getty Images)

The new CAR T-cell therapy is still in its early days, with no data yet available on the long-term survival rates of these patients. Nevertheless, scientists believe there is reason for optimism. 

The research “lends credence to the potential power of CAR-T cells to make a difference in solid tumors, especially the brain,” Dr. Bryan Choi, lead author of the NEJM study and a brain-tumor surgeon at Massachusetts General Hospital, told Nature. “It adds to the excitement that we might be able to move the needle.”

CART-cell therapy has been approved in the U.S. to treat blood cancers, such as lymphomas, some forms of leukemia and multiple myeloma. However, scientists have struggled to develop the therapy for solid tumors, such as glioblastoma, as the cells within them often vary in their characteristics, meaning they have more ways of evading the immune system. 

The new treatments target receptors that are commonly expressed by glioblastoma cells, thus singling them out for destruction. The NEJM study also manufactured T cells that can produce antibodies against these receptors, giving them a second mode of attack. More data is required to evaluate the longer term effects of these new treatments, and trials will need to be conducted in larger, more diverse groups of patients to determine their broader relevance. 

“These results are exciting, but they are also just the beginning — they tell us that we are on the right track in pursuing a therapy that has the potential to change the outlook for this intractable disease,” Dr. Marcela Maus, co-senior author of the NEJM study and director of the Cellular Immunology Program at the Mass General Cancer Center in Massachusetts, said in a statement. 

Ever wonder why some people build muscle more easily than others or why freckles come out in the sun? Send us your questions about how the human body works to [email protected] with the subject line “Health Desk Q,” and you may see your question answered on the website! 

Get the world’s most fascinating discoveries delivered straight to your inbox.

Emily is a health news writer based in London, United Kingdom. She holds a bachelor’s degree in biology from Durham University and a master’s degree in clinical and therapeutic neuroscience from Oxford University. She has worked in science communication, medical writing and as a local news reporter while undertaking journalism training. In 2018, she was named one of MHP Communications’ 30 journalists to watch under 30. ([email protected]) 

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Live Science – https://www.livescience.com/health/medicine-drugs/designer-immune-cell-therapy-could-shrink-deadly-brain-tumors-early-trials-show

Previous Post

James Webb telescope spots organic molecules swirling around unborn stars, hinting at origins of Earth-like worlds

Next Post

Facts about hail, the icy precipitation often encountered in spring and summer

Jacobson earns program’s first medal at U23 World Championships – nmuwildcats.com

Jacobson Breaks New Ground with Program’s First Medal at U23 World Championships

October 22, 2025
AHLA: Hotels generate $7B for Denver economy – Hotel Management

Hotels Drive Denver’s Economy to Soar by $7 Billion

October 22, 2025
AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

AMC Launches First New Dolby Experience in Gwinnett Since 2017

October 22, 2025
UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

October 22, 2025
With Israel-Hamas Cease-Fire, Some Pro-Palestinian Protesters Look Back at Their Movement, Ruefully – The New York Times

With Israel-Hamas Cease-Fire, Some Pro-Palestinian Protesters Look Back at Their Movement, Ruefully – The New York Times

October 21, 2025
Fusobacterium nucleatum : ecology, pathogenesis and clinical implications – Nature

Unveiling Fusobacterium nucleatum: Exploring Its Ecology, Disease Connections, and Health Impact

October 21, 2025
Escherichia coli with a 57-codon genetic code – Science | AAAS

Escherichia coli Engineered with a Revolutionary 57-Codon Genetic Code

October 21, 2025
LOCALIZE IT: Over 420 anti-science bills target public health protections in statehouses across US – newspressnow.com

More Than 420 Anti-Science Bills Jeopardize Public Health Across the Nation

October 21, 2025
Halloween not your thing? Here’s when Christmas at the Newport mansions will start. – The Providence Journal

Not a Halloween Fan? Find Out When Christmas Magic Begins at the Newport Mansions!

October 21, 2025
Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

October 21, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (879)
  • Economy (901)
  • Entertainment (21,772)
  • General (17,729)
  • Health (9,942)
  • Lifestyle (913)
  • News (22,149)
  • People (901)
  • Politics (911)
  • Science (16,111)
  • Sports (21,400)
  • Technology (15,880)
  • World (884)

Recent News

Jacobson earns program’s first medal at U23 World Championships – nmuwildcats.com

Jacobson Breaks New Ground with Program’s First Medal at U23 World Championships

October 22, 2025
AHLA: Hotels generate $7B for Denver economy – Hotel Management

Hotels Drive Denver’s Economy to Soar by $7 Billion

October 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version