* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, October 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home General

Designer immune-cell therapy could shrink deadly brain tumors, early trials show

March 15, 2024
in General
Designer immune-cell therapy could shrink deadly brain tumors, early trials show
Share on FacebookShare on Twitter

Colored CT scan of a section through a person's brain with a glioblastoma shown in orange on the left side of the brain (shown at the top in this image as rotated 90 degrees)

Glioblastomas are the most aggressive form of brain cancer. An example of one of these tumors is shown in the colored brain scan image above in orange.
(Image credit: DR P. MARAZZI/SCIENCE PHOTO LIBRARY via Getty Images)

A new immune cell-based treatment for glioblastoma, the most aggressive type of brain cancer, has shown promise in shrinking tumors in the short-term, according to two early clinical trials. 

The trials tested the safety and effectiveness of a personalized therapy called chimeric antigen receptor (CAR) T-cell therapy. This involves drawing out and genetically manipulating patients’ immune cells, known as T cells, to more effectively recognize and attack tumors once they’re reintroduced into the body. 

One of the trials, described in a paper published Wednesday (March 13) in the New England Journal of Medicine (NEJM), included three patients with recurrent glioblastoma, meaning their cancer had returned following standard radiation and chemotherapy. T cells from these patients were genetically modified to target two versions of a receptor called epidermal growth factor receptor (EGFR) on the surface of tumor cells. 

In the second trial, published the same day in the journal Nature Medicine, researchers used CAR T cells to target EGFR and an additional tumor-related receptor, called interleukin-13 receptor alpha 2, in six patients with recurrent glioblastoma.  

Related: In a 1st, scientists use designer immune cells to send an autoimmune disease into remission

Both trials found that CART-cell therapy was safe and reduced tumor size in all nine patients. In the Nature Medicine study, patients saw these reductions within one or two days, while in the NEJM study they saw them after one to five days. One NEJM patient’s tumor almost completely regressed five days after a single treatment, while another person’s tumor decreased in size by 60.7% after 69 days.

However, these effects didn’t necessarily last. Tumors returned for two patients in the NEJM study, within either 72 days or a month after the initial infusion. The other patient showed no signs of tumor recurrence more than 150 days after treatment, although this was the last assessment point of the study so it is uncertain whether this occurred afterward. Some of the reductions seen in the Nature Medicine study have also been sustained for several months, for example up to seven months in one patient. 

Glioblastomas are notoriously difficult to treat, usually relying on surgery to remove them as well as chemotherapy and radiation to kill the cancerous cells. Each year, more than 10,000 people in the U.S. are diagnosed with glioblastoma. Only 6.9% of them survive beyond five years after diagnosis and most live for only another eight months. 

Medical illustration of two cancer cells in purple against a black background. One of the cancer cells (on the right) is being attacked by a T cell, in gold

CAR-T therapy is an immunotherapy which involves reprogramming T cells to better attack tumors. In the illustration above, a T cell, in brown, can be seen attacking cancer cells, in purple. (Image credit: THOM LEACH / SCIENCE PHOTO LIBRARY via Getty Images)

The new CAR T-cell therapy is still in its early days, with no data yet available on the long-term survival rates of these patients. Nevertheless, scientists believe there is reason for optimism. 

The research “lends credence to the potential power of CAR-T cells to make a difference in solid tumors, especially the brain,” Dr. Bryan Choi, lead author of the NEJM study and a brain-tumor surgeon at Massachusetts General Hospital, told Nature. “It adds to the excitement that we might be able to move the needle.”

CART-cell therapy has been approved in the U.S. to treat blood cancers, such as lymphomas, some forms of leukemia and multiple myeloma. However, scientists have struggled to develop the therapy for solid tumors, such as glioblastoma, as the cells within them often vary in their characteristics, meaning they have more ways of evading the immune system. 

The new treatments target receptors that are commonly expressed by glioblastoma cells, thus singling them out for destruction. The NEJM study also manufactured T cells that can produce antibodies against these receptors, giving them a second mode of attack. More data is required to evaluate the longer term effects of these new treatments, and trials will need to be conducted in larger, more diverse groups of patients to determine their broader relevance. 

“These results are exciting, but they are also just the beginning — they tell us that we are on the right track in pursuing a therapy that has the potential to change the outlook for this intractable disease,” Dr. Marcela Maus, co-senior author of the NEJM study and director of the Cellular Immunology Program at the Mass General Cancer Center in Massachusetts, said in a statement. 

Ever wonder why some people build muscle more easily than others or why freckles come out in the sun? Send us your questions about how the human body works to [email protected] with the subject line “Health Desk Q,” and you may see your question answered on the website! 

Get the world’s most fascinating discoveries delivered straight to your inbox.

Emily is a health news writer based in London, United Kingdom. She holds a bachelor’s degree in biology from Durham University and a master’s degree in clinical and therapeutic neuroscience from Oxford University. She has worked in science communication, medical writing and as a local news reporter while undertaking journalism training. In 2018, she was named one of MHP Communications’ 30 journalists to watch under 30. ([email protected]) 

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Live Science – https://www.livescience.com/health/medicine-drugs/designer-immune-cell-therapy-could-shrink-deadly-brain-tumors-early-trials-show

Previous Post

James Webb telescope spots organic molecules swirling around unborn stars, hinting at origins of Earth-like worlds

Next Post

Facts about hail, the icy precipitation often encountered in spring and summer

Alabama man earns world record for 3-foot, 6-inch beard locks – upi.com

Alabama man earns world record for 3-foot, 6-inch beard locks – upi.com

October 2, 2025
How Trump could use a government shutdown to turbocharge his economic agenda – Yahoo Finance

How Trump could use a government shutdown to turbocharge his economic agenda – Yahoo Finance

October 2, 2025
Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

October 2, 2025
Reproductive Health Emergency Kits To Be Distributed Saturday At Jacksonville Really Really Free Market – Center for Biological Diversity

Reproductive Health Emergency Kits To Be Distributed Saturday At Jacksonville Really Really Free Market – Center for Biological Diversity

October 2, 2025
Times/Siena Survey: Americans Worry Divisions Cannot Be Overcome – The New York Times

Americans Fear Deep Divisions May Be Impossible to Overcome

October 2, 2025
Oak Ridge Reservation Set for $42M Ecological Restoration, Balancing – Hoodline

Oak Ridge Reservation to Undergo $42M Ecological Restoration and Balancing Effort

October 2, 2025
Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

October 2, 2025
A ‘Great Wave’ is rippling through our galaxy, pushing thousands of stars out of place – Live Science

A ‘Great Wave’ is rippling through our galaxy, pushing thousands of stars out of place – Live Science

October 2, 2025
These are the best breweries in New Jersey, according to recent online ranking – Yahoo

These are the best breweries in New Jersey, according to recent online ranking – Yahoo

October 2, 2025
A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

October 2, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (847)
  • Economy (868)
  • Entertainment (21,742)
  • General (17,369)
  • Health (9,911)
  • Lifestyle (881)
  • News (22,149)
  • People (870)
  • Politics (879)
  • Science (16,078)
  • Sports (21,368)
  • Technology (15,851)
  • World (851)

Recent News

Alabama man earns world record for 3-foot, 6-inch beard locks – upi.com

Alabama man earns world record for 3-foot, 6-inch beard locks – upi.com

October 2, 2025
How Trump could use a government shutdown to turbocharge his economic agenda – Yahoo Finance

How Trump could use a government shutdown to turbocharge his economic agenda – Yahoo Finance

October 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version