* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, June 5, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home General

Embolization Proves Its Mettle for Subdural Hematoma

February 11, 2024
in General
Embolization Proves Its Mettle for Subdural Hematoma
Share on FacebookShare on Twitter

PHOENIX — For chronic or subacute subdural hematoma, embolization of the middle meningeal artery (MMA) reduced recurrence, three randomized trials showed.

Two trials with the Onyx liquid embolic system and one with the Squid liquid embolic system were reported with what one presenter called “very consistent” findings at the closing late-breaking science session of the American Stroke Association International Stroke Conference.

The approach has been used sporadically off-label for subdural hematoma, although familiar to neurointerventionalists due to use in dural arteriovenous fistulas and arteriovenous malformation, noted session co-moderator Tudor G. Jovin, MD, of the Cooper Neurological Institute in Camden, New Jersey.

“This is big news, these three trials, because they are establishing this procedure as a standard of care,” he told MedPage Today. “Level one evidence was lacking, and I think this will change practice and change guidelines.”

“I would draw the analogy with the thrombectomy trials of 2015. There were some centers that were doing it, but it wasn’t the standard of care,” he said. “It’s going to be as impactful as the 2015 trials have been for thrombectomy.”

Surgical treatment with craniotomy or by drilling a burr hole to drain the hematoma appears to have been in use for thousands of years, based on archaeological evidence. Conservative medical management with treatments like tranexamic acid administration, steroids, or statins is common as well.

However, post-surgical recurrence rates are up to 20% in many series. A recent systematic review showed a 36% nonsuccess rate for conservative therapy.

“As that fluid has accumulated on the surface of the brain, you tend to develop membranes,” noted Jason Davies, MD, PhD, of the State University of New York at Buffalo. “You have inflammatory cells that come in that have a pro-angiogenic role. You start to get ingrowth of neovascularity from the overlying dura, and those vessels tend to be relatively poorly formed and to be leaky. And so what happens is that these membranes start having repeated microhemorrhages, fluid exudates, and they really take on a life of their own.”

“So the thought is, if we can devascularize these membranes by interrupting the blood vessels, we can dry up the membranes, interrupt that cycle, and hopefully reduce the recurrence rates and improve clinical outcomes for the patient,” he explained.

Onyx Results

Davies reported interim results from the EMBOLISE trial cohort undergoing surgical management. The trial — designed to support an application to the FDA for an expanded indication — also has an arm that randomized patients who elected conservative management without surgery; that data will be reported at a later date.

In the surgical cohort, subdural hematoma recurrence or progression requiring surgical drainage through 90 days occurred in 4.1% of patients randomized to embolization with the Onyx liquid embolization system, compared with 11.3% treated with surgery alone (RR 0.36, 95% CI 0.11-0.80, P=0.0081).

The number needed to treat was about 14, or just 12 in a modified intent-to-treat analysis excluding patients treated outside the protocol.

Deterioration in neurologic function was similar between groups (11.9% and 9.8%, respectively, P=0.0022 for non-inferiority).

The surgical cohort in the trial included 400 patients at 60 centers across the U.S. Inclusion criteria required a premorbid modified Rankin Score (mRS) of 0-3, diagnosis of subacute or chronic subdural hematoma on MRI or CT imaging with corroborating clinical symptoms, and characteristics that ruled out observation alone. Radial access and local anesthesia were encouraged for the procedure.

All embolization procedures achieved technical success for the target vessel, with 1.1% reflux to non-target vessels. Serious adverse events (AEs) related to the embolization procedure occurred in 2% of patients within 30 days, but none of the four cases were deemed related to Onyx.

Neurologic death in the first 90 days were more than twice as common in the embolization group (4.6% vs 2.0%), but almost all were due to the subdural hematoma without any related to Onyx or the embolization procedure. No ipsilateral visual complications or serious intracerebral hemorrhage related to Onyx or the embolization procedure occurred either.

One limitation was about 10% of missed clinic visits at 90-day follow-up given the timing of the trial around the COVID-19 pandemic (December 2020 to August 2023) with a fairly frail, elderly population. The average age was around 71 in the study.

“We believe MMA embolization should be considered as an adjunct for patients who undergo surgical drainage of chronic or subacute subdural hematomas,” concluded co-presenter Jared Knopman, MD, of Weill Cornell Medicine in New York City. “We’re very excited by these results.”

MAGIC-MT

A second trial from China, MAGIC-MT, also showed a 4.93-percentage point reduction in symptomatic recurrence or progression of subdural hematoma or death within 90 days after randomization to MMA embolization using Onyx compared with locally determined care management alone (7.2% vs 12.2%, P=0.02).

Ying Mao, MD, PhD, of Huashan Hospital and Fudan University in Shanghai, reported that the trial included 727 symptomatic non-acute subdural hematoma patients with a shift in midline structure or deformation of local cerebral cortex. It had inclusion criteria similar to the EMBOLIZE trial, Mao noted. It likewise allowed local doctors to decide on conservative management or burr hole drainage, however both groups were randomized into the same trial cohort, unlike EMBOLIZE.

Symptomatic subdural hematoma recurrence (maximum thickness>10 mm) or re-operation within 90 days was numerically less common with embolization in the 78% of patients who underwent burr-hole drainage (4.7% vs 5.2%).

For those managed conservatively, symptomatic subdural hematoma progression showed a larger impact of embolization, with rates of 1.7% versus 4.7%. Other factors associated with a larger treatment effect were known head trauma, smaller midline shift, and smaller hematoma volume.

Safety findings actually showed significantly fewer serious AEs within 90 days in the embolization group (6.7% vs 11.6%, P=0.02). Embolization-related complications occurred in 0.8% of patients, with one case of facial nerve paralysis and two of contrast agent allergy.

SQUID Results

A novel liquid embolization system, dubbed Squid, more than tripled the likelihood of treatment success compared with standard management, reported Adam Arthur, MD, of Semmes-Murphey Neurological Clinic in Memphis, Tennessee, who called the results “very consistent” with what had already been presented at the late-breaking science session.

Embolization with Squid yielded a 15.5% failure rate within 180 days compared with 39.2% using standard management alone (OR 3.60, 95% CI 1.91-6.78) when failure was defined three ways: residual or re-accumulation to at least a 10-mm thick hematoma, re-operation or surgical rescue, or any new major event (disabling stroke, myocardial infarction, or death from any neurological cause).

Notably, patients who had MMA embolization along with conservative management actually had a lower risk of treatment failure than those who got surgery alone (19.1% vs 25.4%). The lowest risk was seen in those who got the combined surgery-plus-embolization strategy (12.3%), whereas fully 59.2% had failure with non-surgical management alone.

The STEM pivotal trial randomized 310 patients (stratified by surgical management, which 189 elected, or non-surgical care).

Participants were ages 30 and older and had premorbid mRS 0-1 in the prior 12 months. Their chronic subdural hematoma needed to be symptomatic and measure at least 10 mm at its thickest point and exert local cortical flattening or midline shift.

No deaths in the trial were attributed to the procedure or device, and 30-day all-cause mortality was similar between treatment arms. The only major disabling stroke occurred in the control group.

Of the other endpoints for which data will be reported later, Arthur noted that mRS shift, hospital length of stay, and neurocognitive scores will be of particular interest.

“Again, we’re looking at an older patient population and trying to help them to maintain independence and maintain cognitive competence later in life,” he concluded.

author['full_name']

Disclosures

EMBOLISE was sponsored by Medtronic.

Davies disclosed relationships with NIH, NSF SBIR, UB CAT, Buffalo Translational Consortium, Cummings Foundation, Nvidia, Google, QAS.ai, Rist Neurovascular, Cerebrotech, Synchron, Hyperion, Medtronic, Microvention, Imperative Care, Xenter, RapidPulse, Canon, Johnson & Johnson, and StrokeNet.

MAGIC-MT was supported by the Shanghai Shenkang Hospital Development Center, Shanghai Municipal Health Commission, and Covidien/Medtronic.

Mao disclosed relationships with Medtronic.

STEM was sponsored by BALT USA.

Arthur disclosed relationships with Arsenal, Cerenovus, Medtronic, Microvention, Neuros, Penumbra, Perfuze, Scientia, Siemens, Stryker, Bendit, EndoStream, Magneto, Mentice, Neurogami, Neuros, Perfuze, RevBio, Scientia, Serenity, Synchron, Tulavi, Vastrax, and Viz.ai.

Jovin disclosed relationships with Cerenovus, Route 92, Galaxy Therapeutics, Methinks, Anaconda , Viz.ai, Kandu Health, StataDX, FreeOx Biotech, Stryker, and Medtronic.

Primary Source

International Stroke Conference

Source Reference: Davies JM, et al “The EMBOLISE study: Embolization of the middle meningeal artery with onyx liquid embolic system in the treatment of subacute and chronic subdural hematoma” ISC 2024; Abstract LB28.

Secondary Source

International Stroke Conference

Source Reference: Mao Y, et al “The MAGIC-MT trial: Managing non-acute subdural hematoma using liquid materials: A Chinese randomized trial of middle meningeal artery treatment” ISC 2024; Abstract LB29.

Additional Source

International Stroke Conference

Source Reference: Arthur A, et al “STEM (The Squid trial for the embolization of the MMA for the treatment of CSDH)” ISC 2024; Abstract LB31.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/isc/108684

Previous Post

Doing Away With Needle Exchange Programs Won’t Prevent Drug Use

Next Post

‘If We Have a Thermonuclear War, All I Need Is a Scalpel’: What We Heard This Week

Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

UBS Analyst Predicts Surge in Micron Technology Stock Price!

June 5, 2025
Senate votes to open RI to new sports betting apps. Would that boost state revenues? – The Providence Journal

Could New Sports Betting Apps Transform Rhode Island’s Revenue Landscape

June 5, 2025
Art meets ecology in the outback – UNSW Sydney

Where Art and Ecology Converge: A Journey Through the Outback

June 5, 2025
Tall ship brings ESA ocean science training to Nice – European Space Agency

Set Sail for Science: Tall Ship Anchors Ocean Research Training in Nice!

June 5, 2025
Immigration Research Shows Stephen Miller Wrong About American Science – Forbes

Debunking Stephen Miller: The Truth About Immigration’s Impact on American Science

June 5, 2025
Can Lifestyle Changes Save Lives in Colon Cancer? – Medscape

Transform Your Health: How Lifestyle Changes Can Combat Colon Cancer

June 5, 2025
Black-hole scattering calculations could shed light on gravitational waves – Physics World

Unlocking the Secrets of Gravitational Waves: The Role of Black-Hole Scattering Calculations

June 5, 2025
Fed: The Economy Is Slowing As ‘Companies Can’t Figure Out the Rules of This Tariff Game’ – Investopedia

Fed Signals Economic Slowdown: Companies Struggle to Navigate the Tariff Maze

June 5, 2025
Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

June 5, 2025
Axxam and Molecular Health link on therapeutic target identification – Pharmaceutical Technology

Unlocking New Possibilities: Axxam and Molecular Health Collaborate on Innovative Therapeutic Target Identification

June 5, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (668)
  • Economy (682)
  • Entertainment (21,588)
  • General (15,264)
  • Health (9,724)
  • Lifestyle (685)
  • News (22,149)
  • People (683)
  • Politics (691)
  • Science (15,901)
  • Sports (21,187)
  • Technology (15,668)
  • World (668)

Recent News

Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

UBS Analyst Predicts Surge in Micron Technology Stock Price!

June 5, 2025
Senate votes to open RI to new sports betting apps. Would that boost state revenues? – The Providence Journal

Could New Sports Betting Apps Transform Rhode Island’s Revenue Landscape

June 5, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version