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FDA approves AstraZeneca, Sanofi shot that protects infants and toddlers against RSV

July 17, 2023
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FDA approves AstraZeneca, Sanofi shot that protects infants and toddlers against RSV
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Blood sample for respiratory syncytial virus (RSV) test

Jarun011 | Istock | Getty Images

The Food and Drug Administration on Monday approved AstraZeneca and Sanofi’s shot that protects infants and toddlers against respiratory syncytial virus, which is the leading cause of hospitalization among babies in the U.S.

Nirsevimab is the first shot approved by the FDA to protect all infants against RSV regardless of whether they are healthy or have a medical condition.

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The FDA approval of nirsevimab, sold under the brand name Beyfortus, comes ahead of RSV season this fall. The Centers for Disease Control and Prevention’s panel of independent experts will meet in August to make recommendations on how the shot should be administered by doctors.

Another shot called palivizumab is already on the market, but it is given mainly to infants who are preterm or who have lung and congenital heart conditions that put them at high risk of severe disease. Nirsevimab is also administered as a single injection. This is a major advantage over palivizumab, which is administered monthly throughout RSV season.

Nirsevimab is administered either before or during an infant’s first RSV season. Toddlers up to two years old who remain vulnerable can also receive the shot during their second RSV season.

RSV is a major public health threat that kills nearly 100 infants annually, according to a study published in the medical journal JAMA Open Network last year. The virus is the leading cause of hospitalization among children less than a year old, according to a study published in the Journal of Infectious Diseases.

A surge in RSV infections last fall overwhelmed children’s hospitals across the U.S. and led to calls for the Biden administration to declare a public health emergency in response.

Nirsevimab was up to 75% effective at preventing lower respiratory tract infections that required medical attention among infants and 78% effective at preventing hospitalization, according to a FDA review.

The FDA did not identified any safety concerns in its review of nirsevimab, though other monoclonal antibodies have been associated with allergic reactions such as skin rashes.

Nirsevimab is a monoclonal antibody that has a similar function to a vaccine. Vaccines stimulate the immune system to produce protective antibodies, while shots like nirsevimab deliver those antibodies directly into the bloodstream.

The fact that nirsevimab is regulated as a drug has created some uncertainty about whether the federal Vaccines for Children program will provide the shot for free to families who face financial difficulties. The CDC advisors are expected to discuss this issue at their August meeting.

Families might have two options to protect their infants this fall. Pfizer has developed a vaccine that protects infants by administering the shot to the mother while she is pregnant. The FDA’s independent advisors recommended Pfizer’s vaccine in May. The agency is expected to make a final decision on whether to approve the shot in August.

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