Healthcare professionals face significant risks when handling hazardous drugs, which include chemotherapy agents, antiviral medications, and hormones. Exposure can occur through inhalation, skin contact, accidental ingestion, or needlestick injuries, often without immediate symptoms. Long-term effects may involve reproductive issues, organ toxicity, and increased cancer risk. Despite strict protocols, recent studies reveal gaps in workplace safety practices, with some facilities lacking sufficient personal protective equipment (PPE) or proper engineering controls like biological safety cabinets.

To mitigate these dangers, the CDC highlights critical measures, including:

  • Mandatory use of certified PPE such as gloves, gowns, and respiratory protection
  • Regular training on safe handling and spill management
  • Implementation of closed-system drug-transfer devices (CSTDs)
  • Routine environmental and biological monitoring to detect contamination
Exposure Route Common Hazardous Drugs Preventive Action
Skin Contact Cytotoxic agents Double gloves, protective gowns
Inhalation Antineoplastics Use of ventilated hoods
Needlestick Injuries Antiviral medications Safe needle disposal systems