* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 1, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home General

Unlocking the Secrets of Myelin Repair

March 26, 2024
in General
Unlocking the Secrets of Myelin Repair
Share on FacebookShare on Twitter

New research from scientists at the Wu Tsai Neurosciences Institute at Stanford University has identified a key driver of myelination, the formation of protective fatty sheaths around nerve fibers. 

Myelination is essential for the rapid transmission of electrical signals in the brain, facilitating everything from movement to thought. The breakdown or loss of this myelin sheath, as seen in conditions like multiple sclerosis and other neurodegenerative diseases, leads to significant cognitive and physical impairments. 

The new findings have researchers excited about the potential for new avenues of treatment to regrow these insulating sheaths in patients with demyelinating disorders.

The research was published March 14, 2024 in the journal PNAS. It was led by Wu Tsai Neurosciences Institute Interdisciplinary Postdoctoral Scholars Tal Iram and Miguel Garcia, and overseen by Institute affiliate J. Bradley Zuchero, an assistant professor in the Department of Neurosurgery.

GOING SRFing: Structural gene SRF is critical for myelin formation

Wu Tsai Neuro Interdisciplinary Postdoctoral Scholar alumni Tal Iram.

The study zeroes in on SRF (short for ‘serum response factor’), a transcription factor previously known for its roles in various cellular processes but not fully understood in the context of myelination. 

Through sophisticated genetic and molecular biology techniques, including ChIP-seq and RNA-seq analyses, the research team identified SRF as a pivotal regulator of the genes involved in the cellular structure of oligodendrocytes—the glial cells responsible for myelinating nerve fibers in the brain and spinal cord.

To create myelin, oligodendrocytes wrap nerve fibers with hundreds of layers of their own fatty cellular membrane, expanding to 25- to 50-thousand times their original surface area in the process. This unique ability depends on a wholesale reorganization of the cells’ structural scaffolding, particularly the actin filaments that are crucial to cells’ structure and movement.

“The cellular machinery required to form these complex myelinating processes and power this sophisticated cell is incredible,” Iram said.

Wu Tsai Neuro Interdisciplinary Postdoctoral Scholar alumni Miguel Garcia.

To understand the role of SRF in myelin formation, the team created “knock-out” models — rodents lacking SRF in their brains’ oligodendrocytes. In these SRF-less animals, the researchers observed a dramatic reduction in the levels of actin filaments during the early stages of cell differentiation. This deficiency hindered the cells’ ability to form the myelin sheath around axons.

The researchers were also surprised to discover that loss of SRF triggered a gene signature previously associated with aging and neurodegenerative diseases such as Alzheimer’s Disease. 

“The most unexpected finding was that SRF seems to repress a disease-related transcriptional signature,” Iram said.

This observation links the new findings with Iram’s recent discovery that oligodendrocyte SRF levels decrease with age in mice — and that infusing aged animals with cerebrospinal fluid from younger mice can boost SRF activation and actin assembly to more youthful levels.

“We believe that the SRF knockout mouse might mimic what is happening in the aged brain where we see less SRF in oligodendrocytes,” Iram explained.

THAT’S A WRAP: Research could lead to new treatments.

This research not only advances scientists’ fundamental understanding of how myelin forms in the developing brain and retains its integrity in adulthood, but also suggests that targeting the SRF gene pathway could be a promising approach to treating myelin-related disorders. 

By boosting SRF activity, the researchers speculate, scientists may be able to promote myelination, protect it against degradation, or even restore it in the context of aging and neurological disease.

“There are still many things we don’t understand about the mechanisms of repression and what are the functional roles of these disease- or aging-associated genes,” said Iram, who is now pursuing these questions in her own laboratory at the Weizmann Institute of Science in Tel Aviv.

GODFATHER OF GLIA: Remembering the impact of Ben Barres

The project has been a passion for Zuchero for many years, since he was a postdoc in the lab of the late Ben Barres, the groundbreaking Stanford neurobiologist who helped put the long-neglected study of the brain’s glial cells back in the spotlight. 

J. Bradley Zuchero, Wu Tsai Neuro Institute affiliate and assistant professor in the Department of Neurosurgery

“After getting some initially interesting results, I hit a conceptual roadblock with how to move forward,” Zuchero said. “After starting my own lab, I passed the torch to my fantastic postdoc Miguel Garcia. Amazingly, Tal’s work in the Wyss-Coray lab was converging on SRF completely independently. This reignited the project and enabled Tal and Miguel to break through the conceptual barriers and make these important discoveries.” 

“I am eternally grateful to Ben Barres for his mentorship and support, allowing his trainees to follow their curiosity and interests in whatever directions they led, and for inspiring a life-long love of glia in me and countless others.”

Banner image at top of page shows actin filaments (cyan) and an actin regulatory protein (magenta) in a differentiating oligodendrocyte. Image Credit: Brad Zuchero and Andrew Olson. Image acquired at the Neurosciences Microscopy Service, a Community Laboratory of the Wu Tsai Neurosciences Institute. The authors also acknowledge research support from the Gene Vector and Virus Core, another Wu Tsai Neuro community laboratory.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Hacker News – https://neuroscience.stanford.edu/news/unlocking-secrets-myelin-repair

Previous Post

Lifelong Disadvantage: How Socioeconomics Affect Brain Function

Next Post

Caitlin Clark breaks single-season scoring record as Iowa survive scare

The billion-year reign of fungi that predated plants and made Earth livable – ScienceDaily

October 1, 2025
We Asked an Entomologist to Fact-Check the Science of ‘Alien: Earth’ – Esquire

We Asked an Entomologist to Fact-Check the Science of ‘Alien: Earth’ – Esquire

October 1, 2025
Building Better Leaders Through the Science of Happiness – Pace University

Unlocking Leadership Potential: How the Science of Happiness Transforms Leaders

October 1, 2025
Viral ‘Goth house’ for sale just in time for Halloween – The Weekly Journal

Step Inside the Spooky ‘Goth House’ Perfect for Halloween!

October 1, 2025
Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

October 1, 2025
Atlanta Braves Manager Brian Snitker Moving to ‘Advisory Role’ – FOX Sports

Atlanta Braves Manager Brian Snitker Moving to ‘Advisory Role’ – FOX Sports

October 1, 2025
The sleepy SF neighborhood that just became one of the world’s coolest – SFGATE

The sleepy SF neighborhood that just became one of the world’s coolest – SFGATE

October 1, 2025
The “stuck economy,” tariffs and Wall Street – marketplace.org

How Tariffs and Wall Street Are Strangling the Economy’s Growth

October 1, 2025
LSU Theatre’s season opener: A handkerchief discovered by a lovesick suitor adds up to hilarity – The Advocate

Love, Laughter, and a Lost Handkerchief: LSU Theatre’s Season Opener Promises Hilarious Fun

October 1, 2025
Rural Health Transformation (RHT) Program – Centers for Medicare & Medicaid Services | CMS (.gov)

Rural Health Transformation (RHT) Program – Centers for Medicare & Medicaid Services | CMS (.gov)

October 1, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (846)
  • Economy (866)
  • Entertainment (21,740)
  • General (17,353)
  • Health (9,910)
  • Lifestyle (880)
  • News (22,149)
  • People (869)
  • Politics (877)
  • Science (16,077)
  • Sports (21,367)
  • Technology (15,850)
  • World (849)

Recent News

The billion-year reign of fungi that predated plants and made Earth livable – ScienceDaily

October 1, 2025
We Asked an Entomologist to Fact-Check the Science of ‘Alien: Earth’ – Esquire

We Asked an Entomologist to Fact-Check the Science of ‘Alien: Earth’ – Esquire

October 1, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version