* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 1, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

A one-molecule immune evasion system: New discovery could land one-two punch against cancer

February 2, 2024
in Health
A one-molecule immune evasion system: New discovery could land one-two punch against cancer
Share on FacebookShare on Twitter

New discovery could land one-two punch against cancer

Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.01.008

A multinational team of researchers led by Columbia University has discovered that tumors can repurpose a single cellular protein to hide themselves from the immune system in two distinct ways. Drugs targeting that protein could strike a double blow against many cancers, and make immunotherapy, one of the newest types of tumor therapies even more effective.

One of the hallmarks of cancer is genome instability, an increased tendency of the genome to acquire mutations during cell division. This genome instability in turn triggers innate immune sensors within the cell, who then recognize the bits of genetic material that leak outside the cell nucleus into the surrounding cytoplasm.

“This can be beneficial in the context of cancer treatment because it can lead to the release of chemokines that attract immune cells into the tumor,” says Alberto Ciccia, associate professor of genetics and development at Columbia and a member of the Herbert Irving Comprehensive Cancer Center. The responding immune cells can then kill the cancerous cell before it gets out of control.

Unfortunately, some cancers manage to activate an immune checkpoint response, essentially a “nothing to see here” signal, to evade the initial response. Recently developed therapies, a type of immunotherapy called checkpoint inhibitors, can overcome that problem by suppressing the checkpoint response, but these immune checkpoint blockade treatments still fail in some patients.

SMARCAL1: A one-molecule immune evasion system

“We were interested to study the interplay between the innate immune response and the immune checkpoint response,” says Ciccia, who is the senior author on the paper describing the new results, published in the journal Cell. A postdoctoral fellow in Ciccia’s lab, Giuseppe Leuzzi, led the study, using a clever genetic screen to identify cellular proteins linked to both responses. “We were expecting to find factors that would up-regulate both responses,” says Ciccia. However, the team discovered a subset of proteins with opposite effects on the two responses.

One protein in particular, called SMARCAL1, seems to suppress innate immune signaling while inducing the production of immune checkpoint proteins; it’s a one-molecule immune evasion system. “When you inactivate this factor, you activate the innate immune pathway, and reduce the expression of one of the immune checkpoint proteins,” says Ciccia.

Working with an international team of collaborators at several other institutions, the investigators demonstrated that the two functions work through two distinct mechanisms. SMARCAL1 operates as a factor that maintains genome stability during DNA replication, and also as a transcription regulator that can induce the production of immune checkpoint proteins.

A promising target for new therapies

“By targeting this factor, we could achieve a dual benefit, increasing innate immunity and infiltration of tumors by immune cells, and limiting the ability of the cancer cells to evade the immune system through immune checkpoints,” says Ciccia. The team tested that idea in a mouse model of tumor immune responses, with promising results. They also analyzed patient data from The Cancer Genome Atlas, and found that high SMARCAL1 expression correlates with poor clinical outcomes.

“We are hoping to be able to develop small-molecule inhibitors of SMARCAL1 and see whether we can recapitulate the effects that we are observing in our genetic models,” says Ciccia. Though he emphasizes that many hurdles remain to turning the new findings into effective therapies, Ciccia is optimistic about the prospects. Indeed, SMARCAL1 wasn’t the only potential target the team identified in the initial screen. “These are factors that when you inactivate them, they might allow you to achieve multiple different responses that could be beneficial,” says Ciccia.

More information:
Giuseppe Leuzzi et al, SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion, Cell (2024). DOI: 10.1016/j.cell.2024.01.008

Citation:
A one-molecule immune evasion system: New discovery could land one-two punch against cancer (2024, February 2)
retrieved 2 February 2024
from https://medicalxpress.com/news/2024-02-molecule-immune-evasion-discovery-cancer.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-02-molecule-immune-evasion-discovery-cancer.html

Tags: healthImmuneone-molecule
Previous Post

Gene editing precisely repairs immune cells

Next Post

Research team uses AI to improve sepsis detection and effective treatment

Milan Fashion Week Asks the Question: Is It the Best-Dressed City in The World? – The New York Times

Milan Fashion Week Asks the Question: Is It the Best-Dressed City in The World? – The New York Times

October 1, 2025
How a government shutdown would impact the economy – CBS News

How a Government Shutdown Could Impact the Economy

October 1, 2025
Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

October 1, 2025

Teresa Nicholson Celebrated as Pardee Hospital’s Teammate of the Year

September 30, 2025
Interim study committee discusses expanding postpartum care for Hoosier women – The Statehouse File

Interim study committee discusses expanding postpartum care for Hoosier women – The Statehouse File

September 30, 2025
Microplastics and invasive crayfish: emerging interactions and ecological implications from three coexisting species in a subalpine lake – Nature

Uncovering the Hidden Impact: How Microplastics and Invasive Crayfish Interact in a Subalpine Lake Ecosystem

September 30, 2025
Scientists Warn: Bottled Water May Pose Serious Long-Term Health Risks – SciTechDaily

Scientists Reveal Shocking Long-Term Health Risks of Bottled Water

September 30, 2025
You Can Trigger ‘Time Expansion’—Meaning You Can Stretch Seconds and Warp Reality, Scientists Say – Popular Mechanics

Unlock the Secret to Stretching Seconds and Bending Reality: Scientists Reveal How to Trigger ‘Time Expansion

September 30, 2025
Roiserv Lifestyle Services Announces Key Corporate Changes at Upcoming EGM – TipRanks

Roiserv Lifestyle Services Announces Exciting Corporate Overhaul Ahead of Key EGM

September 30, 2025
Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

September 30, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (844)
  • Economy (865)
  • Entertainment (21,740)
  • General (17,336)
  • Health (9,909)
  • Lifestyle (878)
  • News (22,149)
  • People (867)
  • Politics (876)
  • Science (16,075)
  • Sports (21,365)
  • Technology (15,848)
  • World (848)

Recent News

Milan Fashion Week Asks the Question: Is It the Best-Dressed City in The World? – The New York Times

Milan Fashion Week Asks the Question: Is It the Best-Dressed City in The World? – The New York Times

October 1, 2025
How a government shutdown would impact the economy – CBS News

How a Government Shutdown Could Impact the Economy

October 1, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version