* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, May 12, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Dan Spilo Out at Industry Entertainment After Incident on Set of Alan Ritchson Movie (Exclusive) – The Hollywood Reporter

    Dan Spilo Exits Industry Entertainment Following Controversial Incident on Set of Alan Ritchson Film

    John Legend Says He’s Shocked by Ye’s ‘Descent’ Into ‘Antisemitism’ and ‘Anti-Blackness’ – Yahoo

    John Legend Expresses Shock Over Ye’s Troubling Descent into Antisemitism and Anti-Blackness

    Free Flowin’ Fest brings entertainment to Pascagoula’s Beach Park – WLOX

    Experience the Excitement: Free Flowin’ Fest Lights Up Pascagoula’s Beach Park!

    ‘Experimental entertainment venue’ sets sights on Austin area – MySA

    ‘Experimental entertainment venue’ sets sights on Austin area – MySA

    Taylor Swift’s team calls subpoena in Blake Lively-Justin Baldoni case ‘tabloid clickbait’ – Yahoo

    Taylor Swift’s Team Slams Subpoena in Blake Lively-Justin Baldoni Case as ‘Tabloid Clickbait

    The Weeknd made the apocalypse sexy at his 2025 tour launch in Arizona – Yahoo

    The Weeknd Turns Up the Heat at His 2025 Tour Launch in Arizona!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Arkansas Tech Univeristy-Ozark collision repair technology program re-accredited – Northwest Arkansas Democrat-Gazette

    Arkansas Tech University-Ozark’s Collision Repair Technology Program Earns Re-Accreditation!

    Top Chief Technology Officers to Watch in 2025: SMX’s Anthony Vultaggio – WashingtonExec

    Top Chief Technology Officers to Watch in 2025: SMX’s Anthony Vultaggio – WashingtonExec

    Well completions per location more than double in Lower 48 states as technology advances – U.S. Energy Information Administration (EIA) (.gov)

    Revolutionizing Oil Production: Lower 48 States See Doubling of Well Completions Thanks to Technological Breakthroughs!

    Officials announce massive project that could reshape electric vehicle technology: ‘This is exactly the type of investment that will help us grow the economy’ – Yahoo Finance

    Game-Changer Ahead: Major Investment Set to Transform Electric Vehicle Technology and Boost the Economy!

    Federal agents raid Dymeng Technology Solutions in St. Augustine – Action News Jax

    Federal Agents Storm Dymeng Technology Solutions in St. Augustine: What You Need to Know

    SoundHound’s Amelia 7.0 Platform Delivers Agentic AI With Category Leading Voice Technology – Business Wire

    Unleashing the Future: SoundHound’s Amelia 7.0 Revolutionizes Voice Technology with Agentic AI

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Dan Spilo Out at Industry Entertainment After Incident on Set of Alan Ritchson Movie (Exclusive) – The Hollywood Reporter

    Dan Spilo Exits Industry Entertainment Following Controversial Incident on Set of Alan Ritchson Film

    John Legend Says He’s Shocked by Ye’s ‘Descent’ Into ‘Antisemitism’ and ‘Anti-Blackness’ – Yahoo

    John Legend Expresses Shock Over Ye’s Troubling Descent into Antisemitism and Anti-Blackness

    Free Flowin’ Fest brings entertainment to Pascagoula’s Beach Park – WLOX

    Experience the Excitement: Free Flowin’ Fest Lights Up Pascagoula’s Beach Park!

    ‘Experimental entertainment venue’ sets sights on Austin area – MySA

    ‘Experimental entertainment venue’ sets sights on Austin area – MySA

    Taylor Swift’s team calls subpoena in Blake Lively-Justin Baldoni case ‘tabloid clickbait’ – Yahoo

    Taylor Swift’s Team Slams Subpoena in Blake Lively-Justin Baldoni Case as ‘Tabloid Clickbait

    The Weeknd made the apocalypse sexy at his 2025 tour launch in Arizona – Yahoo

    The Weeknd Turns Up the Heat at His 2025 Tour Launch in Arizona!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Arkansas Tech Univeristy-Ozark collision repair technology program re-accredited – Northwest Arkansas Democrat-Gazette

    Arkansas Tech University-Ozark’s Collision Repair Technology Program Earns Re-Accreditation!

    Top Chief Technology Officers to Watch in 2025: SMX’s Anthony Vultaggio – WashingtonExec

    Top Chief Technology Officers to Watch in 2025: SMX’s Anthony Vultaggio – WashingtonExec

    Well completions per location more than double in Lower 48 states as technology advances – U.S. Energy Information Administration (EIA) (.gov)

    Revolutionizing Oil Production: Lower 48 States See Doubling of Well Completions Thanks to Technological Breakthroughs!

    Officials announce massive project that could reshape electric vehicle technology: ‘This is exactly the type of investment that will help us grow the economy’ – Yahoo Finance

    Game-Changer Ahead: Major Investment Set to Transform Electric Vehicle Technology and Boost the Economy!

    Federal agents raid Dymeng Technology Solutions in St. Augustine – Action News Jax

    Federal Agents Storm Dymeng Technology Solutions in St. Augustine: What You Need to Know

    SoundHound’s Amelia 7.0 Platform Delivers Agentic AI With Category Leading Voice Technology – Business Wire

    Unleashing the Future: SoundHound’s Amelia 7.0 Revolutionizes Voice Technology with Agentic AI

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

An overgrowth of nerve cells appears to cause lingering symptoms after recurrent UTIs

March 2, 2024
in Health
An overgrowth of nerve cells appears to cause lingering symptoms after recurrent UTIs
Share on FacebookShare on Twitter

 nerve cell

Credit: Pixabay/CC0 Public Domain

A perplexing problem for people with recurring urinary tract infections (UTIs) is persistent pain, even after antibiotics have successfully cleared the bacteria.

Now Duke Health researchers have identified the likely cause—an overgrowth of nerve cells in the bladder.

The finding, appearing March 1 in the journal Science Immunology, provides a potential new approach to managing symptoms of recurring UTIs that would more effectively target the problem and reduce unnecessary antibiotic usage.

“Urinary tract infections account for almost 25% of infections in women,” said senior author Soman Abraham, Ph.D., professor in the departments of Pathology, Molecular Genetics and Microbiology, Integrative Immunobiology, and Cell Biology at Duke University School of Medicine.

“Many are recurrent UTIs, with patients frequently complaining of chronic pelvic pain and urinary frequency, even after a round of antibiotics,” Abraham said. “Our study, for the first time, describes an underlying cause and identifies a potential new treatment strategy.”

Abraham and colleagues collected bladder biopsies from recurrent UTI patients who were experiencing pain despite no culturable bacteria in their urine. Using biopsies from people without UTIs as a comparison, they found evidence that sensory nerves were highly activated in the UTI patients, explaining the persistent sense of pain and urinary frequency.

Further studies in mice revealed the underlying events, with unique conditions in the bladder that prompt activated nerves in the lining to bloom and grow with each infection.

“Typically, during every bout of UTI, epithelial cells laden with bacteria are sloughed off, and significant destruction of nearby nerve tissue occurs,” said Byron Hayes, lead author of the study and previously a postdoctoral fellow in Duke’s Department of Pathology. “These events trigger a rapid repair program in the damaged bladder involving massive regrowth of destroyed nerve cells.”

This immune response, including repair activities, is led by mast cells—which are immune cells that fight infection and allergens. Mast cells release chemicals called nerve growth factor, which drive overgrowth and increase sensitivity of nerves. The result is pain and urgency.

The researchers were able to address these symptoms by treating study mice with molecules that suppress production of the mast-cell generated nerve growth factor.

“This work helps illuminate a puzzling clinical condition that drives medical costs and affects the quality of life of millions of people, primarily women,” Abraham said. “Understanding the crosstalk between mast cells and nerves is an essential step toward effective treatments for people suffering repeat urinary tract infections.”

More information:
Byron Hayes et al, Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity, Science Immunology (2024). DOI: 10.1126/sciimmunol.adi5578. www.science.org/doi/10.1126/sciimmunol.adi5578

Citation:
An overgrowth of nerve cells appears to cause lingering symptoms after recurrent UTIs (2024, March 1)
retrieved 1 March 2024
from https://medicalxpress.com/news/2024-03-overgrowth-nerve-cells-lingering-symptoms.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-03-overgrowth-nerve-cells-lingering-symptoms.html

Tags: healthNerveovergrowth
Previous Post

COVID-19 no longer means five days in isolation, CDC says

Next Post

Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

Stable isotope ecology of Quaternary cervid and bovid species in Southeast Asia with implications for wildlife conservation – Nature

Unraveling the Secrets of Southeast Asia’s Quaternary Deer and Bovids: Insights for Wildlife Conservation

May 12, 2025
College Credits: Arlington Heights Student Teaches Science At Carthage – Patch

Arlington Heights Student Inspires Future Scientists Through Teaching at Carthage

May 12, 2025
National Science Foundation faces lawsuit over 15% indirect research cap – Higher Ed Dive

National Science Foundation Sued Over Controversial 15% Cap on Indirect Research Costs

May 12, 2025
Tamil actor Silambarasan shares his fitness advice for maintaining healthy lifestyle at 42: ‘Avoid heavy meals at night’ – Hindustan Times

Unlocking Ageless Vitality: Silambarasan’s Top Fitness Tips for a Healthy Lifestyle at 42!

May 12, 2025
Brazil signs Real Madrid coach Carlo Ancelotti ahead of 2026 World Cup – FOX Sports

Brazil Welcomes Real Madrid’s Carlo Ancelotti as Head Coach for 2026 World Cup!

May 12, 2025
Japan’s Sputtering Economy Likely Stalled Before Trump’s Tariffs – Bloomberg.com

Japan’s Economy Hits a Standstill: The Impact of Trump’s Tariffs

May 12, 2025
Dan Spilo Out at Industry Entertainment After Incident on Set of Alan Ritchson Movie (Exclusive) – The Hollywood Reporter

Dan Spilo Exits Industry Entertainment Following Controversial Incident on Set of Alan Ritchson Film

May 12, 2025
Pregnancy Health Problems Increase Kids’ Blood Pressure – U.S. News & World Report

How Pregnancy Health Issues Can Impact Your Child’s Blood Pressure

May 12, 2025
State lawmakers criticize Gov. Hochul’s policy-laden budget strategy – Spectrum News

State Lawmakers Take Aim at Gov. Hochul’s Controversial Budget Strategy

May 12, 2025
Arkansas Tech Univeristy-Ozark collision repair technology program re-accredited – Northwest Arkansas Democrat-Gazette

Arkansas Tech University-Ozark’s Collision Repair Technology Program Earns Re-Accreditation!

May 12, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (603)
  • Economy (615)
  • Entertainment (21,527)
  • General (15,214)
  • Health (9,657)
  • Lifestyle (620)
  • News (22,149)
  • People (617)
  • Politics (622)
  • Science (15,837)
  • Sports (21,124)
  • Technology (15,605)
  • World (605)

Recent News

Stable isotope ecology of Quaternary cervid and bovid species in Southeast Asia with implications for wildlife conservation – Nature

Unraveling the Secrets of Southeast Asia’s Quaternary Deer and Bovids: Insights for Wildlife Conservation

May 12, 2025
College Credits: Arlington Heights Student Teaches Science At Carthage – Patch

Arlington Heights Student Inspires Future Scientists Through Teaching at Carthage

May 12, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version