Anti-androgens may be beneficial for managing certain hyperandrogenism-related symptoms of polycystic ovary syndrome (PCOS) in cases where combined oral contraceptive pills are contraindicated, poorly tolerated, or ineffective, according to the first systematic review and meta-analysis on the subject.
Using data from 13 studies including a total of 961 patients, combination treatment with antiandrogens, metformin, and lifestyle intervention helped to lower testosterone levels in patients with PCOS compared with metformin and lifestyle intervention alone (weighted mean difference [WMD] -0.29 nmol/L, 95% CI -0.52 to -0.06, P=0.01), reported Aya Mousa, PhD, of Monash University in Clayton, Australia, and colleagues.
According to their study published in eClinicalMedicine, adding anti-androgens to lifestyle intervention was also superior to lifestyle intervention with metformin in managing:
Hirsutism: WMD -1.59 (95% CI -3.06 to -0.12, P=0.03)Sex-hormone binding globulin (SHBG): WMD 7.70 nmol/L (95% CI 0.75-14.66, P=0.03)Fasting insulin: WMD -2.11 μU/mL (95% CI -3.97 to -0.26, P=0.03)Fasting insulin to glucose ratio: WMD -1.12 (95% CI -1.44 to -0.79, P
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