* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, October 25, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    CNN Launches New Show – What to Know About Host Elex Michaelson – Central Oregon Daily

    Get to Know Elex Michaelson: The Dynamic New Host Taking CNN by Storm

    Johnny Depp Set To Finally Make His Big Hollywood Comeback After Amber Heard Controversy – Yahoo

    Johnny Depp Set for a Triumphant Hollywood Comeback Following Amber Heard Controversy

    ‘Chainsaw Man — The Movie: Reze Arc’ Review: Hit Manga Gets an Ultra-Violent, Surprisingly Emotional Big-Screen Adaptation – Yahoo

    Chainsaw Man – The Movie: Reze Arc Review: A Brutal and Unexpectedly Emotional Big-Screen Adaptation

    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    New technology for grading and packing dates – FreshPlaza

    Revolutionary Technology Transforms Date Grading and Packing Process

    Project underway to upgrade technology on 911 towers in Kanawha County – WCHS

    Kanawha County Launches Major Upgrade to 911 Tower Technology

    Next steps: Technology opens new options for greater mobility – Missouri Independent

    Next Steps: How Technology is Opening Exciting New Doors to Greater Mobility

    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    CNN Launches New Show – What to Know About Host Elex Michaelson – Central Oregon Daily

    Get to Know Elex Michaelson: The Dynamic New Host Taking CNN by Storm

    Johnny Depp Set To Finally Make His Big Hollywood Comeback After Amber Heard Controversy – Yahoo

    Johnny Depp Set for a Triumphant Hollywood Comeback Following Amber Heard Controversy

    ‘Chainsaw Man — The Movie: Reze Arc’ Review: Hit Manga Gets an Ultra-Violent, Surprisingly Emotional Big-Screen Adaptation – Yahoo

    Chainsaw Man – The Movie: Reze Arc Review: A Brutal and Unexpectedly Emotional Big-Screen Adaptation

    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    New technology for grading and packing dates – FreshPlaza

    Revolutionary Technology Transforms Date Grading and Packing Process

    Project underway to upgrade technology on 911 towers in Kanawha County – WCHS

    Kanawha County Launches Major Upgrade to 911 Tower Technology

    Next steps: Technology opens new options for greater mobility – Missouri Independent

    Next Steps: How Technology is Opening Exciting New Doors to Greater Mobility

    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Anti-Ro/SSA Antibodies Have Potential to Predict ILD in SSc

June 15, 2024
in Health
Anti-Ro/SSA Antibodies Have Potential to Predict ILD in SSc
Share on FacebookShare on Twitter

VIENNA — Anti-Ro/SSA antibodies may help predict which patients with systemic sclerosis (SSc) are at a greater risk for interstitial lung disease (ILD) and may serve as a biomarker to guide screening, according to an analysis of data from a large European cohort.

The researchers were led by Blaž Burja, MD, PhD, a physician-scientist at the Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, who reported that anti-Ro/SSA antibodies are a risk factor for ILD, with an odds ratio of 1.24, in patients with SSc.

At the European Alliance of Associations for Rheumatology (EULAR) 2024 Annual Meeting, he presented the findings of the study that aimed to find out if SSc-nonspecific antibodies might help better risk-stratify patients with SSc, focusing on lung involvement. “Among them, anti-Ro/SSA antibodies have been shown to be associated with interstitial lung disease in different connective tissue diseases,” Burja pointed out.

“A total of 15% of all patients in the SSc cohort presented with anti-Ro/SSA antibodies, and this subgroup presented with distinct clinical features: Importantly, higher prevalence of ILD and lower DLCO% [diffusing capacity of the lungs for carbon monoxide] in patients with established ILD,” reported Burja, adding that, “However, these anti-Ro/SSA antibodies do not predict ILD progression, death, or overall disease progression.”

Based on the findings, Burja suggested that these antibodies be incorporated into routine clinical practice to identify patients with SSc who have a high risk for ILD. He noted that “this has specific importance in clinical settings without availability of high-resolution computed tomography (HRCT), where anti-Ro/SSA antibodies could represent an additional biomarker to guide the screening process, in particular, in patients without SSc-specific antibodies.”

Caroline Ospelt, MD, PhD, co-moderator of the session and scientific program chair of EULAR 2024, told Medscape Medical News that the study was unique in its approach to studying ILD risk by “looking outside the box, so not just at specific antibodies but whether cross-disease antibodies may have value in stratifying patients and help predict risk of lung involvement and possibly monitor these patients.”

Ospelt, who is a professor of experimental rheumatology at University Hospital Zürich and was not involved in the study, noted that “It might also be the case that we could adapt this concept and use these antibodies in other rheumatic diseases, too, not just systemic sclerosis, to predict lung involvement.”

Risk-Stratifying With SSc-Nonspecific Antibodies

Burja explained that despite better stratification of patients with SSc with SSc-specific antibodies, “in clinical practice, we see large heterogeneity, and individual prognosis with regards to outcomes is still unpredictable, so we wanted to know whether by using nonspecific autoantibodies we might be better able to risk-stratify these patients.”

A study population of 4421 with at least one follow-up visit, including 3060 patients with available follow-up serologic data, was drawn from the European Scleroderma Trials and Research group database (n=22,482). Of these 3060 patients, 461 were positive for anti-Ro/SSA antibodies and 2599 were negative. The researchers analyzed the relationships between baseline characteristics and the development or progression of ILD over 2.7 years of follow-up. Incident, de novo ILD was defined based on its presence on HRCT, and progression was defined by whether the percentage of predicted forced vital capacity (FVC%) dropped ≥ 10%, FVC% dropped 5%-9% in association with a DLCO% drop ≥ 15%, or FVC% dropped> 5%. Deaths from all causes and prognostic factors for the progression of lung fibrosis during follow-up were recorded.

High Prevalence of ILD With Anti-Ro/SSA Antibodies in SSc

At baseline, patients with anti-Ro/SSA antibodies were aged 55-56 years, 84%-87% were women, and muscular involvement was present in 18% of patients positive for anti-Ro/SSA antibodies and 12.5% of those who were negative (P <.001 according to hrct ild was present in of patients positive for anti-ro antibodies and those who were negative fvc dlco>

“A total of 15% of all SSc patients presented as positive for anti-Ro/SSA antibodies, and these patients all presented with higher prevalence of SSA-nonspecific antibodies, too: Of note, those with anti-La/SSB and anti-U1/RNP and rheumatoid factor,” Burja reported.

In patients with anti-U1/RNP autoantibodies, 1% were positive and 4% were negative for anti-Ro/SSA antibodies; in those with anti-La/SSB autoantibodies, 17% were positive and 1% were negative for anti-Ro/SSA antibodies; and in those with rheumatoid factor, 28% were positive and 14% were negative for anti-Ro/SSA antibodies.

Burja pointed out that the average disease duration in the study cohort at baseline was 7 years, “and at this timepoint, we expect to see some common disease manifestations. Specifically, higher muscular involvement and higher ILD based on HRCT.”

“We decided to focus on patients with established ILD at baseline,” said Burja, “Anti-Ro/SSA-positive patients with established ILD at baseline presented with lower DLCO values at 59% in patients positive for anti-Ro/SSA antibodies and 61% for those who were negative,” Burja said.

After conducting a multivariable analysis of 14,066 healthcare visits and adjusting for known risk factors for ILD, the researchers concluded that anti-Ro/SSA antibodies are an independent risk factor for ILD, with an odds ratio of 1.24 (95% CI, 1.07-1.44; P=.006). They also determined that anti-Ro/SSA antibodies are a risk factor for lower DLCO values in patients with ILD, with a regression coefficient of −1.93.

The researchers then explored the progression of ILD and overall disease progression and survival during the follow-up period in a longitudinal analysis. “However, anti-Ro/SSA antibodies were not found to predict the progression of ILD,” reported Burja, adding that this was true regardless of the definition of ILD progression used. “Nor did anti-Ro/SSA antibodies do not predict survival or overall disease progression.”

Burja pointed out the limitations in his study, including the lack of standardized criteria for all centers to assess anti-Ro/SSA positivity; there was a lack of discrimination between anti-Ro52 and anti-Ro60 subtypes, and there were no standardized applicable criteria to study lung progression in SSc.

Burja and Ospelt had no relevant financial disclosures.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/anti-ro-ssa-antibodies-have-potential-predict-ild-systemic-2024a1000b4m

Tags: Anti-Roantibodieshealth
Previous Post

Upadacitinib Improves Giant Cell Arteritis in Phase 3 Trial

Next Post

How do cicadas make their signature sound, so eerie and amazingly loud?

Nutritional supplements boost baby coral survival – EurekAlert!

How Nutritional Supplements Are Boosting Baby Coral Survival Rates

October 25, 2025
Scientists Are One Step Closer to Letting Humans ‘Breathe’ Through Their Butts – Yahoo

Scientists Are One Step Closer to Letting Humans ‘Breathe’ Through Their Butts – Yahoo

October 25, 2025
Bizarre Crystals in Titan’s Lakes Could Break a Fundamental Rule of Chemistry – ScienceAlert

Strange Crystals Found in Titan’s Lakes Challenge a Fundamental Chemistry Rule

October 25, 2025
Mortgage Rates Inch Toward 6% as Fed Weighs October Cut – IslanderNews.com

Mortgage Rates Surge Near 6% Amid Speculation of October Fed Rate Cut

October 25, 2025
Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

October 25, 2025
This Week in Sports Trivia: October 23, 2025 – The Athletic – The New York Times

Think You’re a Sports Expert? Take on This Week’s October 23, 2025 Trivia Challenge!

October 25, 2025
How to watch the 2025 MLB World Series: Dodgers vs. Blue Jays game schedule, channels, streaming, when is Shohei Ohtani starting and more – Yahoo Sports

Ultimate Guide to Watching the 2025 MLB World Series: Dodgers vs. Blue Jays Game Schedule, Channels, Streaming, and Shohei Ohtani’s Start Time

October 24, 2025
A circular economy approach for the global lithium-ion battery supply chain – Nature

Revolutionizing the Global Lithium-Ion Battery Supply Chain Through a Circular Economy Approach

October 24, 2025
CNN Launches New Show – What to Know About Host Elex Michaelson – Central Oregon Daily

Get to Know Elex Michaelson: The Dynamic New Host Taking CNN by Storm

October 24, 2025
Idaho Medicaid mental health contractor to cut doctor pay rates by 4%-15% – Idaho Capital Sun

Idaho Medicaid Mental Health Contractor to Cut Doctor Pay Rates by Up to 15%

October 24, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (885)
  • Economy (906)
  • Entertainment (21,777)
  • General (17,790)
  • Health (9,947)
  • Lifestyle (919)
  • News (22,149)
  • People (907)
  • Politics (916)
  • Science (16,117)
  • Sports (21,406)
  • Technology (15,886)
  • World (889)

Recent News

Nutritional supplements boost baby coral survival – EurekAlert!

How Nutritional Supplements Are Boosting Baby Coral Survival Rates

October 25, 2025
Scientists Are One Step Closer to Letting Humans ‘Breathe’ Through Their Butts – Yahoo

Scientists Are One Step Closer to Letting Humans ‘Breathe’ Through Their Butts – Yahoo

October 25, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version