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    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

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    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

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    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

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    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

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Antiparasitic Wins FDA Approval for High-Risk Neuroblastoma

December 15, 2023
in Health
Antiparasitic Wins FDA Approval for High-Risk Neuroblastoma
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The US Food and Drug Administration (FDA) approved eflornithine (Iwilfin) to reduce the risk for relapse in patients with high-risk neuroblastoma who have demonstrated at least a partial response to prior multiagent, multimodality therapy, including anti-GD2 immunotherapy. 

This approval is the first of a therapy intended to reduce the risk for relapse in pediatric patients with high-risk neuroblastoma, the agency said in a press release. 

Developed in the 1970s, an injectable formulation of eflornithine has been used as an antiparasitic to treat sleeping sickness in Africa, and a topical version has been used to curb excessive facial hair growth in women. These two formulations of eflornithine, however, have been discontinued in the United States. 

The new approval is for an oral formulation dosed according to body surface area. Studies in more than 100 patients and more than 1000 controls demonstrated a reduction in event-free survival, defined as disease progression, relapse, secondary cancer, or death from any cause.

Findings from the analysis revealed a 51%-57% decrease in event-free survival in patients who had at least a partial response to previous treatment. Eflornithine was also associated with improved overall survival (hazard ratio, 0.29-0.45). 

Adverse events in 5% of patients or more include otitis media, diarrhea, cough, sinusitis, pneumonia, upper respiratory tract infection, conjunctivitis, vomiting, pyrexia, allergic rhinitis, decreased neutrophils, increased ALT, increased AST, hearing loss, skin infection, and urinary tract infection. 

M. Alexander Otto is a physician assistant with a master’s degree in medical science and a journalism degree from Newhouse. He is an award-winning medical journalist who worked for several major news outlets before joining Medscape. Alex is also an MIT Knight Science Journalism fellow. Email: [email protected].

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/antiparasitic-wins-fda-approval-high-risk-neuroblastoma-2023a1000vg4

Tags: AntiparasiticApprovalhealth
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