* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, June 5, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

At-Home Electrical Stimulation Fails to Treat Major Depressive Episodes

January 4, 2024
in Health
At-Home Electrical Stimulation Fails to Treat Major Depressive Episodes
Share on FacebookShare on Twitter

Unsupervised, at-home use of transcranial direct current stimulation (tDCS) was no better than a sham control for treating a major depressive episode, a randomized trial showed.

The PSYLECT trial of 210 adults in Brazil showed no differences in mean changes in Hamilton Depression Rating Scale-17 (HDRS-17) scores over 6 weeks across three groups: a double-active group, a tDCS-only group, and a double-sham group (8.2, 8.5, and 7.7, respectively), Andre Brunoni, MD, PhD, of the University of São Paulo Medical School in Brazil, and colleagues reported in JAMA Psychiatry.

“It seems that tDCS might take more time than 6 weeks to develop clinically meaningful effects,” Brunoni told MedPage Today in an email. “Therefore, it should not be used, particularly as monotherapy, in more severe episodes in which a faster response is necessary.”

Better treatments for major depression are sorely needed, the researchers said. Unlike transcranial magnetic stimulation and electroconvulsive therapy, they said, tDCS is portable, inexpensive, and has minimal side effects. The problem is that it needs to be applied daily, which can be limited by clinical worker availability and patient ability to come into the clinic.

Thus, at-home use of tDCS could be a good alternative treatment, and at least one small study has shown promising results in depression, the researchers said. Indeed, portable tDCS devices have been developed and adopted, but no rigorously controlled trials of their efficacy have been done.

Also, studies of in-clinic tDCS have had varying results. A previous trial by Brunoni and colleagues published in the New England Journal of Medicine showed tDCS beat placebo for treating depression (though it couldn’t show non-inferiority to the antidepressant escitalopram [Lexapro]) in a clinical setting. However, another study Brunoni was involved in, published in The Lancet, showed tDCS was no better than sham stimulation when paired with a selective serotonin reuptake inhibitor for treating major depressive disorder.

So Brunoni and colleagues conducted the PSYLECT trial, which enrolled 210 people in Brazil (86% female, mean age 38.9, 72% white) with an HDRS-17 score above 16 and access to a smartphone and internet at home. Exclusion criteria were any other psychiatric disorders besides anxiety, any neurologic or clinical disorders, and any contraindications for tDCS.

Participants were randomly assigned to one of three groups of at-home use: a double-active group involving tDCS plus digital intervention (64), a tDCS-only group (73), and a double-sham group that used sham stimulation and a digital placebo (73).

For the stimulation intervention, participants were given a device that administered 2-mA stimulation and were asked to conduct 30-minute sessions each day for 15 straight weekdays. During the final 3 weeks, participants switched to twice-weekly sessions.

For the double-active group, the added digital intervention was delivered during the stimulation and was based on behavioral therapy. The digital placebo consisted of free internet browsing using the same interface as the active intervention. Sham stimulation was 1 mA for 90 seconds.

Response rates, a secondary outcome of the study, were similar across groups (31% for double-active, 36% for tDCS-only, and 38% for double-sham), as were remission rates (14%, 18%, and 21%, respectively), the researchers found.

The results couldn’t be explained by low adherence or poor usability of the at-home tDCS device, although both have been problematic in previous home-based trials, the researchers said. The home-based setting could have diminished the placebo response, but the findings were similar to previous on-site trials of tDCS as well, they noted.

Brunoni noted that the short trial duration was a key limitation of the study, as it was likely too short to produce meaningful clinical effects. Other limitations include the lack of precision on electrode positioning and the heterogeneous effects of the digital intervention modules.

He and colleagues concluded that the results suggested tDCS was ineffective for major depressive episodes, especially as a home-based intervention.

“The main indication of tDCS continues to be for mild depressive disorder, in which [it] is possible to wait several weeks for antidepressant effects,” Brunoni said. He added that tDCS “could be an interesting alternative, for instance, coupled with other non-pharmaceutical interventions, such as physical activity.”

author['full_name']

Michael DePeau-Wilson is a reporter on MedPage Today’s enterprise & investigative team. He covers psychiatry, long covid, and infectious diseases, among other relevant U.S. clinical news. Follow

Disclosures

The trial was funded by a grant from the São Paulo Research State Foundation. Flow Neuroscience donated funds used for paying clinical and research staff directly involved in the trial.

The authors reported financial relationships with Flow Neuroscience, Sooma, Brainsway Inc., Mag & More, NeuroCare, and Neurive.

Primary Source

JAMA Psychiatry

Source Reference: Borrione L, et al “Home-use transcranial direct current stimulation for the treatment of a major depressive episode: A randomized clinical trial” JAMA Psych 2024; DOI: 10.1001/jamapsychiatry.2023.4948.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/psychiatry/depression/108114

Tags: At-Home‎Electricalhealth
Previous Post

Make the Diagnosis: Eeesh….When Something Goes “Pop” While You’re Weightlifting

Next Post

Opening Blood-Brain Barrier to Deliver Alzheimer’s Drug Shows Promise

The Ecology of Visitation – National Park Service (.gov)

Exploring the Impact of Visitor Interactions on Natural Ecosystems

June 5, 2025
Students play with science at Camp Invention at School of Innovation – News-Herald

Unleashing Creativity: Students Dive into Science at Camp Invention!

June 5, 2025
Are cold plunges good for you? Here’s what the science says. – The Washington Post

Unlocking the Benefits of Cold Plunges: What Science Reveals!

June 5, 2025
Casino magnate Alvin Chau’s wife Heidi Chan embraces Buddhist lifestyle after husband’s incarceration – VnExpress International

Casino magnate Alvin Chau’s wife Heidi Chan embraces Buddhist lifestyle after husband’s incarceration – VnExpress International

June 5, 2025
How each of the 32 teams qualified for the 2025 Club World Cup – The New York Times

Unveiling the Path: How All 32 Teams Earned Their Spot in the 2025 Club World Cup

June 5, 2025
Service side of the U.S. economy contracts for first time in almost a year due to trade fights – MarketWatch

U.S. Service Sector Shrinks for the First Time in Nearly a Year Amid Trade Tensions

June 5, 2025
‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

June 5, 2025
Sutter Health investing $23 million in primary and behavioral care – Healthcare Finance News

Sutter Health investing $23 million in primary and behavioral care – Healthcare Finance News

June 5, 2025
Gov. Shapiro sues USDA over canceled $13M food purchasing program – LancasterOnline

Gov. Shapiro sues USDA over canceled $13M food purchasing program – LancasterOnline

June 5, 2025
Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

Domo Set to Shine at the D.A. Davidson Technology Summit!

June 5, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (667)
  • Economy (681)
  • Entertainment (21,587)
  • General (15,261)
  • Health (9,723)
  • Lifestyle (684)
  • News (22,149)
  • People (682)
  • Politics (690)
  • Science (15,901)
  • Sports (21,185)
  • Technology (15,667)
  • World (668)

Recent News

The Ecology of Visitation – National Park Service (.gov)

Exploring the Impact of Visitor Interactions on Natural Ecosystems

June 5, 2025
Students play with science at Camp Invention at School of Innovation – News-Herald

Unleashing Creativity: Students Dive into Science at Camp Invention!

June 5, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version