* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, June 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Beefed-Up Antibiotic Prophylaxis No Help for Post-Arthroplasty Infections

October 19, 2023
in Health
Beefed-Up Antibiotic Prophylaxis No Help for Post-Arthroplasty Infections
Share on FacebookShare on Twitter

Adding vancomycin to beta-lactam prophylaxis with cefazolin did not help prevent surgical-site infections in patients undergoing arthroplasty mostly for the knees or hips, a randomized trial showed.

In over 4,000 patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization, surgical-site infections at 90 days occurred in 4.5% of those who received the combination compared with 3.5% of those who received cefazolin plus placebo (relative risk [RR] 1.28, 95% CI 0.94-1.73, P=0.11), reported Trisha N. Peel, MBBS, PhD, of Monash University in Melbourne, Australia, and co-authors in the New England Journal of Medicine.

“Not only did we find that it wasn’t beneficial, but there was some concern that there might be an associated increased risk of infection or harm,” Peel told MedPage Today.

For example, surgical-site infections in patients undergoing knee arthroplasty occurred in 5.7% of the vancomycin group versus 3.7% of the placebo group (RR 1.52, 95% CI 1.04-2.23).

“It’s quite logical to think, well, if we give more antibiotics, we’ll have better outcomes, or it will prevent these infections,” said Peel. “We found that in our cohort, if they didn’t have MRSA on their skin at the time of surgery, we don’t need to be giving everyone vancomycin — that the cefazolin prevents the infections, there’s no added benefit from using the vancomycin.”

Knee and hip surgeries are both common in the U.S., with post-surgery infections responsible for high rates of morbidity and mortality.

Current antibiotic guidelines recommend a first- or second-generation cephalosporin antimicrobial agent, like cefazolin, at the time of surgery. But because this antibiotic may not prevent cases of MRSA and methicillin-resistant Staphylococcus epidermidis infections, adding a glycopeptide antimicrobial like vancomycin has been thought to help provide broader protection. The benefit of this approach, however, was not yet clear, Peel and team noted.

Previous studies have showed that adding a glycopeptide to antimicrobial beta-lactam prophylaxis has yielded either no change in surgical-site infections or a reduced incidence. However, the studies showing a reduction used teicoplanin, not vancomycin, as the glycopeptide.

Kalpana Gupta, MD, MPH, of the VA Boston Healthcare System in West Roxbury, Massachusetts, told MedPage Today that the current study was very well done.

“A lot of places may just go ahead and use two drugs for some of these high-risk procedures, because they’re not looking for MRSA,” she said. “But they know that there’s a small percentage of patients who would have it, and this study suggests that such a strategy would really not have any benefit, and actually has a downside.”

Gupta, who was not involved in the study, also noted that vancomycin can take a long time to administer, and can also lead to adverse effects.

Limiting vancomycin use for this patient population can also have implications for antimicrobial stewardship, she said. “Giving the narrowest spectrum [of antimicrobials] that is indicated has benefits. Those benefits are not only reducing the risk of resistance down the road, but also reducing untoward effects.”

For the multicenter, double-blind Australian Surgical Antibiotic Prophylaxis (ASAP) trial, conducted from 2019 to 2022, Peel and colleagues randomized 4,113 patients from 11 Australian hospitals: 2,233 undergoing knee arthroplasty, 1,850 undergoing hip arthroplasty, and 30 undergoing shoulder arthroplasty. Only patients without known MRSA colonization were included. The primary analysis was performed in a modified intention-to-treat analysis.

Mean age of participants was 66.6 in the vancomycin group (48% men) and 67.1 in the placebo group (47.8% men).

Patients were randomized to receive 1.5 g of intravenous vancomycin or normal saline placebo within 120 minutes of incision. Both groups received prophylaxis with 2 g of cefazolin administered intravenously within 60 minutes of incision.

Adverse events occurred in 1.7% of patients each in the vancomycin and placebo groups, and included hypersensitivity reactions in 1.2% and 0.5%, respectively, and acute kidney injury in 2.1% and 3.6%, respectively.

Peel and team acknowledged that the study was limited by early closures during the COVID-19 pandemic that prevented timely enrollment. They also noted a lack of generalizability to patients with MRSA colonization, revision surgery patients at higher risk for infection from resistant Staphylococcus species, and shoulder arthroplasty patients, because of small numbers. In addition, some treating physicians (4.5%) declined to participate in the trial, which may have contributed to selection bias.

author['full_name']

Sophie Putka is an enterprise and investigative writer for MedPage Today. Her work has appeared in the Wall Street Journal, Discover, Business Insider, Inverse, Cannabis Wire, and more. She joined MedPage Today in August of 2021. Follow

Disclosures

This study was funded by the Australian National Health and Medical Research Council.

Peel reported being a section editor for Native Vertebral Osteomyelitis and Linezolid for UpToDate.

Co-authors reported grants from the National Health and Medical Research Council and relationships with AMR Action Fund, Aurobac Therapeutics, bioMérieux, BioVersys, CARB-X, Entasis, Merck, Pfizer, Shionogi, Spero, and Zuellig.

Gupta has received funding from the VA for research on surgical infections.

Primary Source

New England Journal of Medicine

Source Reference: Peel NP, et al “Trial of vancomycin and cefazolin as surgical prophylaxis in arthroplasty” N Engl J Med 2023; DOI: 10.1056/NEJMoa2301401.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/surgery/orthopedics/106884

Tags: AntibioticBeefed-Uphealth
Previous Post

What to Know About the HV.1 Variant

Next Post

ART Embryo Transfers to Gestational Carriers Increased Chances of Pregnancy

Restoration cannot be scaled up globally to save reefs from loss and degradation – Nature

Reviving Our Reefs: The Challenge of Scaling Up Restoration Efforts Globally

June 2, 2025
Attorney General Bonta Sues to Stop Termination, Withholding of National Science Foundation Grants – State of California – Department of Justice (.gov)

Attorney General Bonta Takes Action to Protect National Science Foundation Grants

June 2, 2025
Exclusive: US veterans agency orders scientists not to publish in journals without clearance – The Guardian

US Veterans Agency Imposes New Restrictions on Scientific Publishing

June 2, 2025
Upper Allen Township launches new initiative to encourage a more active lifestyle – fox43.com

Upper Allen Township launches new initiative to encourage a more active lifestyle – fox43.com

June 2, 2025
Lionel Messi rejoins Argentina for two World Cup qualifiers before Club World Cup – USA Today

Lionel Messi rejoins Argentina for two World Cup qualifiers before Club World Cup – USA Today

June 2, 2025
Jobs Report Could Be Early Sign of Tariffs Cost – U.S. News & World Report

Jobs Report Could Be Early Sign of Tariffs Cost – U.S. News & World Report

June 2, 2025
Mark Tremonti Headlines Belmont Stakes Day Entertainment – Thoroughbred Daily News

Mark Tremonti Takes Center Stage at Belmont Stakes Day Celebration!

June 2, 2025
Black Book Research: Health Plans Double Down on AI-Powered Fraud and Claims Integrity Solutions Amid Rising Audit Pressures – Newswire :) Press Release Distribution

Health Plans Embrace AI to Combat Fraud and Enhance Claims Integrity Amid Growing Audit Challenges

June 2, 2025
Opinion | The Politics and Perils of Pornography – The New York Times

Navigating the Complex Landscape of Pornography: Politics, Perils, and Perspectives

June 2, 2025
Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

Men Charged with Illegally Exporting U.S. Military Technology to China

June 2, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (660)
  • Economy (674)
  • Entertainment (21,580)
  • General (15,257)
  • Health (9,717)
  • Lifestyle (677)
  • News (22,149)
  • People (676)
  • Politics (683)
  • Science (15,895)
  • Sports (21,179)
  • Technology (15,661)
  • World (662)

Recent News

Restoration cannot be scaled up globally to save reefs from loss and degradation – Nature

Reviving Our Reefs: The Challenge of Scaling Up Restoration Efforts Globally

June 2, 2025
Attorney General Bonta Sues to Stop Termination, Withholding of National Science Foundation Grants – State of California – Department of Justice (.gov)

Attorney General Bonta Takes Action to Protect National Science Foundation Grants

June 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version