* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

    Comanche Nation Entertainment closes casino near Devol – KSWO 7News

    Comanche Nation Entertainment Closes Casino Near Devol in Surprising Move

    Erykah Badu Announces ‘Abi & Alan’ Album With The Alchemist Will Be Delayed – yahoo.com

    Erykah Badu Opens Up About the Delay of Her Highly Anticipated ‘Abi & Alan’ Album with The Alchemist

    If You Needed Some BTS Pics Of The Rock’s Tree Trunk Legs To Spice Up Your Day, We Got ‘Em – yahoo.com

    Need a Boost? Check Out These Epic BTS Shots of The Rock’s Tree Trunk Legs!

    Sabrina Carpenter’s pearl-clutching magic? Humor – CNN

    Sabrina Carpenter’s pearl-clutching magic? Humor – CNN

    South Park Is In Trouble And Needs To Change Course, Fast – yahoo.com

    South Park Faces Major Challenges and Must Adapt Fast to Survive

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    China’s CATL sells stake in Finnish subcontract car manufacturer – Reuters

    China’s CATL Sells Stake in Finnish Auto Supplier in Strategic Move

    This Secret Technology Will Make The IPhone 17 Super Thin Air – VOI.ID

    How This Breakthrough Technology Will Make the iPhone 17 Incredibly Thin and Lightweight

    Gator football kicks off with excitement and new technology – WCJB | TV20

    Gator Football Kicks Off with Thrilling Action and Innovative Technology

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Propelling solar technology into a perovskite future – CORDIS

    Propelling solar technology into a perovskite future – CORDIS

    13 Top Technology Trends (2025) – Exploding Topics

    13 Game-Changing Technology Trends to Watch in 2025

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

    Comanche Nation Entertainment closes casino near Devol – KSWO 7News

    Comanche Nation Entertainment Closes Casino Near Devol in Surprising Move

    Erykah Badu Announces ‘Abi & Alan’ Album With The Alchemist Will Be Delayed – yahoo.com

    Erykah Badu Opens Up About the Delay of Her Highly Anticipated ‘Abi & Alan’ Album with The Alchemist

    If You Needed Some BTS Pics Of The Rock’s Tree Trunk Legs To Spice Up Your Day, We Got ‘Em – yahoo.com

    Need a Boost? Check Out These Epic BTS Shots of The Rock’s Tree Trunk Legs!

    Sabrina Carpenter’s pearl-clutching magic? Humor – CNN

    Sabrina Carpenter’s pearl-clutching magic? Humor – CNN

    South Park Is In Trouble And Needs To Change Course, Fast – yahoo.com

    South Park Faces Major Challenges and Must Adapt Fast to Survive

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    China’s CATL sells stake in Finnish subcontract car manufacturer – Reuters

    China’s CATL Sells Stake in Finnish Auto Supplier in Strategic Move

    This Secret Technology Will Make The IPhone 17 Super Thin Air – VOI.ID

    How This Breakthrough Technology Will Make the iPhone 17 Incredibly Thin and Lightweight

    Gator football kicks off with excitement and new technology – WCJB | TV20

    Gator Football Kicks Off with Thrilling Action and Innovative Technology

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Propelling solar technology into a perovskite future – CORDIS

    Propelling solar technology into a perovskite future – CORDIS

    13 Top Technology Trends (2025) – Exploding Topics

    13 Game-Changing Technology Trends to Watch in 2025

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Biomedical engineers unveil the dynamics of maternal immune responses

December 17, 2023
in Health
Biomedical engineers unveil the dynamics of maternal immune responses
Share on FacebookShare on Twitter

Biomedical engineers unveil the dynamics of maternal immune responses

Mechanistic model captures IgG subclass-specific transfer dynamics. Credit: PLOS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1011109

Sepideh Dolatshahi, an assistant professor of biomedical engineering at the University of Virginia, is spearheading an exploration of systems immunology in its crucial development phase—during pregnancy.

Systems immunology is about unraveling concealed patterns within the human immune system, said Dolatshahi, whose approaches to her research span computational modeling, systems serology and cutting-edge spatial analysis techniques to investigate immune interactions between mother and fetus during pregnancy that could later support early childhood immunity.

Designing tailored and effective vaccine plans

Babies are immunocompromised and rely on antibodies from their mothers to protection against infections. Mothers are vaccinated during pregnancy to help increase and customize the antibodies passed on to the baby. While early vaccines such as tetanus, diphtheria and pertussis (TDAP), and recently respiratory syncytial virus (RSV), have shown astounding success, the number of vaccines available to mothers is limited and babies remain vulnerable to many pathogens.

The Dolatshahi lab is working to shed light on how vaccines given to pregnant women interact with both their changing immune system and the developing placenta to confer immune protection in the baby. The team’s goal is to design personalized vaccination strategies that can be especially beneficial to vulnerable patients, for example, those who have genetic complications or compromised immune systems.

To accomplish this, Dolatshahi and her colleagues developed the first computer-based predictive model of maternal vaccination and placental antibody transfer. This model now serves as a tool to help doctors and pre-clinical researchers test different vaccination strategies in silico before embarking on costly, tedious clinical trials, and to shorten the timeline for when patients might benefit from the resulting immunization protocols.

The importance of placental development

The placenta is a protective gatekeeper that safeguards the fetus, governing which substances can reach the growing baby. Shockingly, little is known about the specifics of how the placenta regulates the passage of antibodies from mother to baby.

To shed light on this process and understand which interactions are responsible for conferring transfer of protective antibodies to the baby, Dolatshahi’s team is taking a closer look at the important molecules expressed by placental cells and how they work together to transport antibodies.

By examining this specific process using spatial analysis tools, they hope to uncover information that will identify new targets of maternal vaccines that will maximize the benefit to the baby.

Uncovering variability across the population

During pregnancy the mother’s immune system is in constant flux, so there is no reason to believe that vaccination during pregnancy should be a one-size-fits-all approach. Dolatshahi and her team hope to uncover key variables affecting placental antibody transfer that might contribute to differences across the population.

By defining what causes some babies to receive more maternal antibodies than others, Dolatshahi’s work will help doctors identify patients who may benefit from specially designed vaccines to best support their baby’s immune system. More broadly, this investigation will shed light on the biological and socioeconomic factors which make some women more prone to immune-related pregnancy complications.

This research stands as a milestone to understanding the nuances of how maternal antibodies traverse the placenta and confer protection in newborn babies, and to uncovering specific immune-related mechanisms of pregnancy complications such as preterm birth and preeclampsia. Dolatshahi’s research sets the stage for a more profound comprehension of the immune system’s behavior during pregnancy, offering a promising trajectory for further advancements in this critical domain.

The team’s publication about this research, “Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies,” has been accepted for publication by PLOS Computational Biology.

More information:
Remziye E. Wessel et al, Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies, PLOS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1011109

Citation:
Biomedical engineers unveil the dynamics of maternal immune responses (2023, December 16)
retrieved 17 December 2023
from https://medicalxpress.com/news/2023-12-biomedical-unveil-dynamics-maternal-immune.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-biomedical-unveil-dynamics-maternal-immune.html

Tags: Biomedicalengineershealth
Previous Post

Microbiome insights found in poop help predict infections in liver transplant patients

Next Post

Unstable ‘fluttering’ predicts aortic aneurysm with 98% accuracy

Construction of forest ecological security patterns based on MSPA model and circuit theory in the Desertification Control forests in South China Karst – Nature

Construction of forest ecological security patterns based on MSPA model and circuit theory in the Desertification Control forests in South China Karst – Nature

September 2, 2025
Bringing life science to life: Park Crossing teacher recognized – WSFA

Bringing life science to life: Park Crossing teacher recognized – WSFA

September 2, 2025
Take flight: EH seventh-graders learn science through paper airplanes – The Daily Reporter – Greenfield Indiana

Soar to New Heights: Seventh-Graders Explore Science with Paper Airplanes

September 2, 2025
Marcos orders lifestyle audit of all government officials — Dateline Philippines – Asian Journal News

Marcos Initiates Comprehensive Lifestyle Audit of Government Officials to Boost Accountability

September 2, 2025
China’s CATL sells stake in Finnish subcontract car manufacturer – Reuters

China’s CATL Sells Stake in Finnish Auto Supplier in Strategic Move

September 2, 2025
Mariners call up top catcher prospect Harry Ford, which could help Cal Raleigh late in season – Yahoo Sports

Mariners Elevate Top Catcher Prospect Harry Ford, Strengthening Cal Raleigh’s Late-Season Push

September 2, 2025
ECB’s Lagarde warns of risk to world economy via Trump interference on Fed – Reuters

ECB’s Lagarde warns of risk to world economy via Trump interference on Fed – Reuters

September 1, 2025
The Resilient Engine: Investing in Poland’s Outperforming Economy Amid Global Slowdown – AInvest

The Resilient Engine: Why Investing in Poland’s Booming Economy Is a Smart Move Amid Global Slowdown

September 1, 2025
Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

September 1, 2025
Arts to promote mental health goal of new University of Michigan clinical program – MLive.com

Innovative University of Michigan Program Harnesses the Arts to Enhance Mental Health

September 1, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (802)
  • Economy (820)
  • Entertainment (21,700)
  • General (16,804)
  • Health (9,861)
  • Lifestyle (835)
  • News (22,149)
  • People (822)
  • Politics (828)
  • Science (16,031)
  • Sports (21,319)
  • Technology (15,801)
  • World (801)

Recent News

Construction of forest ecological security patterns based on MSPA model and circuit theory in the Desertification Control forests in South China Karst – Nature

Construction of forest ecological security patterns based on MSPA model and circuit theory in the Desertification Control forests in South China Karst – Nature

September 2, 2025
Bringing life science to life: Park Crossing teacher recognized – WSFA

Bringing life science to life: Park Crossing teacher recognized – WSFA

September 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version