* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Biomedical engineers unveil the dynamics of maternal immune responses

December 17, 2023
in Health
Biomedical engineers unveil the dynamics of maternal immune responses
Share on FacebookShare on Twitter

Biomedical engineers unveil the dynamics of maternal immune responses

Mechanistic model captures IgG subclass-specific transfer dynamics. Credit: PLOS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1011109

Sepideh Dolatshahi, an assistant professor of biomedical engineering at the University of Virginia, is spearheading an exploration of systems immunology in its crucial development phase—during pregnancy.

Systems immunology is about unraveling concealed patterns within the human immune system, said Dolatshahi, whose approaches to her research span computational modeling, systems serology and cutting-edge spatial analysis techniques to investigate immune interactions between mother and fetus during pregnancy that could later support early childhood immunity.

Designing tailored and effective vaccine plans

Babies are immunocompromised and rely on antibodies from their mothers to protection against infections. Mothers are vaccinated during pregnancy to help increase and customize the antibodies passed on to the baby. While early vaccines such as tetanus, diphtheria and pertussis (TDAP), and recently respiratory syncytial virus (RSV), have shown astounding success, the number of vaccines available to mothers is limited and babies remain vulnerable to many pathogens.

The Dolatshahi lab is working to shed light on how vaccines given to pregnant women interact with both their changing immune system and the developing placenta to confer immune protection in the baby. The team’s goal is to design personalized vaccination strategies that can be especially beneficial to vulnerable patients, for example, those who have genetic complications or compromised immune systems.

To accomplish this, Dolatshahi and her colleagues developed the first computer-based predictive model of maternal vaccination and placental antibody transfer. This model now serves as a tool to help doctors and pre-clinical researchers test different vaccination strategies in silico before embarking on costly, tedious clinical trials, and to shorten the timeline for when patients might benefit from the resulting immunization protocols.

The importance of placental development

The placenta is a protective gatekeeper that safeguards the fetus, governing which substances can reach the growing baby. Shockingly, little is known about the specifics of how the placenta regulates the passage of antibodies from mother to baby.

To shed light on this process and understand which interactions are responsible for conferring transfer of protective antibodies to the baby, Dolatshahi’s team is taking a closer look at the important molecules expressed by placental cells and how they work together to transport antibodies.

By examining this specific process using spatial analysis tools, they hope to uncover information that will identify new targets of maternal vaccines that will maximize the benefit to the baby.

Uncovering variability across the population

During pregnancy the mother’s immune system is in constant flux, so there is no reason to believe that vaccination during pregnancy should be a one-size-fits-all approach. Dolatshahi and her team hope to uncover key variables affecting placental antibody transfer that might contribute to differences across the population.

By defining what causes some babies to receive more maternal antibodies than others, Dolatshahi’s work will help doctors identify patients who may benefit from specially designed vaccines to best support their baby’s immune system. More broadly, this investigation will shed light on the biological and socioeconomic factors which make some women more prone to immune-related pregnancy complications.

This research stands as a milestone to understanding the nuances of how maternal antibodies traverse the placenta and confer protection in newborn babies, and to uncovering specific immune-related mechanisms of pregnancy complications such as preterm birth and preeclampsia. Dolatshahi’s research sets the stage for a more profound comprehension of the immune system’s behavior during pregnancy, offering a promising trajectory for further advancements in this critical domain.

The team’s publication about this research, “Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies,” has been accepted for publication by PLOS Computational Biology.

More information:
Remziye E. Wessel et al, Quantitative mechanistic model reveals key determinants of placental IgG transfer and informs prenatal immunization strategies, PLOS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1011109

Citation:
Biomedical engineers unveil the dynamics of maternal immune responses (2023, December 16)
retrieved 17 December 2023
from https://medicalxpress.com/news/2023-12-biomedical-unveil-dynamics-maternal-immune.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-biomedical-unveil-dynamics-maternal-immune.html

Tags: Biomedicalengineershealth
Previous Post

Microbiome insights found in poop help predict infections in liver transplant patients

Next Post

Unstable ‘fluttering’ predicts aortic aneurysm with 98% accuracy

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Much Worse Than Local Studies Show

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Launches $50M Autism Data Science Initiative to Uncover Causes and Improve Lives

September 23, 2025
Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

September 23, 2025
10 money lessons Boomers learned young that still shape their life choices – VegOut

10 Powerful Money Lessons Boomers Learned Early That Still Shape Their Lives Today

September 23, 2025
Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

September 23, 2025
Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

September 23, 2025
U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

September 23, 2025
AI Tool Predicts Health Problems in Patients 20 Years Before They Emerge – eWeek

AI Tool Detects Health Issues Two Decades Before Symptoms Appear

September 23, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (833)
  • Economy (853)
  • Entertainment (21,731)
  • General (17,200)
  • Health (9,896)
  • Lifestyle (866)
  • News (22,149)
  • People (856)
  • Politics (863)
  • Science (16,064)
  • Sports (21,353)
  • Technology (15,836)
  • World (837)

Recent News

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Much Worse Than Local Studies Show

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Launches $50M Autism Data Science Initiative to Uncover Causes and Improve Lives

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version