SAN DIEGO — A bispecific immune checkpoint inhibitor significantly improved survival in advanced gastric/gastroesophageal junction (GEJ) cancer, irrespective of PD-L1 expression status, a large study from China showed.
Median overall survival (OS) increased from 10.8 months with chemotherapy to 15.0 months with the addition of cadonilimab, which targets both PD-1 and CTLA-4. Results significantly favored the cadonilimab arm in patients with a PD-L1 expression combined positive score (CPS) ≥5 and those with a CPS
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