* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, September 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Pendulum Announce Homecoming 2026 Australian Tour – yahoo.com

    Pendulum Announces Thrilling Homecoming Tour Across Australia in 2026

    ITV Studios Launches New Entertainment Label – Global Bulletin – IMDb

    ITV Studios Unveils Exciting New Entertainment Label

    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

    Liam Payne’s Cousin Ross Harris Honors Late Singer With Emotional Song ‘Bones’ – yahoo.com

    Liam Payne’s Cousin Ross Harris Honors Late Singer with Emotional New Song ‘Bones

    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Coherent Joins LLNL’s STARFIRE Diode Technology Working Group to Advance Inertial Fusion Energy – GlobeNewswire

    Coherent Partners with LLNL’s STARFIRE Team to Drive Breakthroughs in Inertial Fusion Energy

    Gene Associated With Deadly Heart Disease in Golden Retrievers Identified – Technology Networks

    Breakthrough Discovery Uncovers Gene Behind Deadly Heart Disease in Golden Retrievers

    Monkey Island LNG Picks ConocoPhillips’ Liquefaction Technology – Hart Energy

    Monkey Island LNG Selects ConocoPhillips’ Advanced Liquefaction Technology for Next-Gen Energy Solutions

    Credo Technology Group Holding Ltd. (CRDO) Surpasses Q1 Earnings and Revenue Estimates – Yahoo Finance

    Credo Technology Group Surpasses Q1 Earnings and Revenue Expectations

    The Economist is hiring a science and technology correspondent – The Economist

    Exciting Opportunity: Become Our Next Science and Technology Correspondent!

    Blockchain lender Figure Technology seeks to raise up to $526M in IPO (FIGR:Pending) – Seeking Alpha

    Blockchain Lender Figure Technology Sets Sights on $526M in Thrilling IPO Launch

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Pendulum Announce Homecoming 2026 Australian Tour – yahoo.com

    Pendulum Announces Thrilling Homecoming Tour Across Australia in 2026

    ITV Studios Launches New Entertainment Label – Global Bulletin – IMDb

    ITV Studios Unveils Exciting New Entertainment Label

    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

    Liam Payne’s Cousin Ross Harris Honors Late Singer With Emotional Song ‘Bones’ – yahoo.com

    Liam Payne’s Cousin Ross Harris Honors Late Singer with Emotional New Song ‘Bones

    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Coherent Joins LLNL’s STARFIRE Diode Technology Working Group to Advance Inertial Fusion Energy – GlobeNewswire

    Coherent Partners with LLNL’s STARFIRE Team to Drive Breakthroughs in Inertial Fusion Energy

    Gene Associated With Deadly Heart Disease in Golden Retrievers Identified – Technology Networks

    Breakthrough Discovery Uncovers Gene Behind Deadly Heart Disease in Golden Retrievers

    Monkey Island LNG Picks ConocoPhillips’ Liquefaction Technology – Hart Energy

    Monkey Island LNG Selects ConocoPhillips’ Advanced Liquefaction Technology for Next-Gen Energy Solutions

    Credo Technology Group Holding Ltd. (CRDO) Surpasses Q1 Earnings and Revenue Estimates – Yahoo Finance

    Credo Technology Group Surpasses Q1 Earnings and Revenue Expectations

    The Economist is hiring a science and technology correspondent – The Economist

    Exciting Opportunity: Become Our Next Science and Technology Correspondent!

    Blockchain lender Figure Technology seeks to raise up to $526M in IPO (FIGR:Pending) – Seeking Alpha

    Blockchain Lender Figure Technology Sets Sights on $526M in Thrilling IPO Launch

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Bivalent COVID Shots May Hold Up Better Against Severe Omicron

July 21, 2023
in Health
Bivalent COVID Shots May Hold Up Better Against Severe Omicron
Share on FacebookShare on Twitter

A second booster with an mRNA bivalent vaccine offered the best protection against severe COVID-19 due to the Omicron BA.5 variant in older adults, and protection appeared to wane less than with the monovalent shot, a large retrospective study out of Italy showed.

Among over 2 million people ages 60 and up, the relative vaccine effectiveness (rVE) was 50.6% in the overall time interval 14 to 118 days post-administration for those who received a bivalent BA.4/5 booster, 49.3% with the bivalent BA.1 booster, and 26.9% with the monovalent booster, reported Alberto Mateo-Urdiales, PhD, of the Istituto Superiore di Sanità in Rome, and colleagues.

Waning of protection following the second booster dose was observed at 60 to 118 days, which was more apparent with the monovalent vaccine (rVE 20.7%) compared with the bivalent BA.1-containing vaccine (42.5%) and the BA.4/5-containing vaccine (34.7%), they noted in Lancet Infectious Diseases.

“In a context where over 90% of SARS-CoV-2 infections were caused by Omicron BA.5, a second booster of an mRNA vaccine conferred additional protection against severe COVID-19 for the first 4 months post-administration compared with receiving only a first booster at least 120 days earlier (median time of 9 months), which is the time when a person is eligible to receive a second booster in Italy, given that the protection induced by the first booster dose has likely waned after 120 days,” Mateo-Urdiales and co-authors wrote.

“Further research, based on a longer follow-up time and conducted in a calendar period with predominant circulation of the Omicron subvariant XBB (currently predominant in Italy), is recommended to gain more information for adequately planning the timing of booster dose administration,” they concluded.

There were no relevant differences in rVE with a booster dose of the bivalent BA.4/5 vaccine in adults ages 60 to 79 and those 80 and older. Overall, in the 14 to 118 days post-administration, rVE among the 60-79 age group was 53.6% compared with 48.3% in those 80 and older.

The researchers estimated that the number needed to vaccinate to prevent one case of severe COVID-19 over 4 months was 535 in the overall population, and 887 in the 60-79 age group and 233 in the 80 and older age group.

They also pointed out that slightly higher rVE was seen when the definition of severe outcomes was narrowed specifically to COVID deaths and hospital admissions (53.1%).

While the findings on waning vaccine protection “could reflect a better match between the spike protein antigen targeted in the bivalent vaccine and the predominantly circulating Omicron BA.5 sublineage in Italy at the time, caution needs to be exercised in interpreting these results as showing evidence for superior effectiveness of the bivalent vaccines,” wrote Shabir Madhi, MBBCh, PhD, of the University of the Witwatersrand in Johannesburg, and Daniel Feikin, MD, of the World Health Organization, in an editorial comment.

“The ideal comparative vaccine effectiveness estimates between monovalent and bivalent COVID-19 vaccine boosters would be a setting where both vaccines are used contemporaneously in a non-targeted manner,” they noted, pointing out that the magnitude of the differences between monovalent and bivalent vaccines in the current Italian study is, at least in part, potentially due to residual confounding, particularly since the outcome was severe COVID-19 disease, where there has been less reduction in vaccine-induced protection against Omicron due to the relative preservation of cellular immune response against Omicron that is induced by ancestral-virus monovalent COVID-19 vaccines.”

“Time-varying confounding would also affect evaluations of the effectiveness of future COVID-19 vaccines, including the recommended XBB-containing monovalent vaccines currently being developed,” they added. “Hence, comparisons of newer COVID-19 vaccine formulations in relation to earlier vaccine formulations should be interpreted in light of the potential for similar time-variant confounding.”

For this study, Mateo-Urdiales and colleagues used data from the Italian vaccination registry and the SARS-CoV-2 surveillance system from September 2022 to January 2023. They matched 2,129,559 adults ages 60 and up receiving a second booster 1:1 with a person who had received the first booster only at least 120 days earlier.

The study population consisted of 116,822 participants who received second doses of a monovalent booster, 670,496 who received a BA.1-containing bivalent, and 1,342,241 who received a BA.4/5-containing bivalent. Slightly over half of participants were women; median age was 74 in the monovalent booster group and 73 in the bivalent booster groups. In each group, 15% of participants were considered high risk, including residents in long-term care facilities and those with relevant comorbidities.

The researchers noted that their study was limited by unmeasured, unknown characteristics that were not accounted for, as well as likely underestimated infections. In addition, waning protection may be underestimated for the BA.4/5 booster, since the time interval post-vaccination was shorter than the other booster groups. Moreover, there may have been other COVID strains circulating.

author['full_name']

Ingrid Hein is a staff writer for MedPage Today covering infectious disease. She has been a medical reporter for more than a decade. Follow

Disclosures

The study was funded by the NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases.

Mateo-Urdiales and co-authors reported no conflicts of interest.

Madhi reported receiving grant funds paid to his institution related to COVID-19 vaccines from the Bill and Melinda Gates Foundation and the South African Medical Research Council, and funds for clinical trials of COVID-19 vaccines from Novavax. Feikin reported no competing interests.

Primary Source

Lancet Infectious Diseases

Source Reference: Mateo-Urdiales A, et al “Relative effectiveness of monovalent and bivalent mRNA boosters in preventing severe COVID-19 due to omicron BA.5 infection up to 4 months post-administration in people aged 60 years or older in Italy: a retrospective matched cohort study” Lancet Infect Dis 2023; DOI: 10.1016/S1473-3099(23)00374-2.

Secondary Source

Lancet Infectious Diseases

Source Reference: Madhi SA, Feikin DR “Are bivalent vaccines better than ancestral-virus monovalent vaccines in protecting against severe omicron COVID-19?” Lancet Infect Dis 2023; DOI: 10.1016/S1473-3099(23)00425-5.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/infectiousdisease/covid19vaccine/105572

Tags: BivalentCOVIDhealth
Previous Post

NN-REC/SPORT/MASTHEADS/NCAU-TOP-SPORT (192655)

Next Post

Rishi Sunak suffers double by-electoin defeat

Abby Dow and England near record territory as Australia search for upset – The Guardian

Abby Dow and England Close in on Record as Australia Hunts for an Upset

September 6, 2025
America is getting the economy we voted for – Noah Smith | Substack

America Is Finally Experiencing the Economy We Created

September 6, 2025
Pendulum Announce Homecoming 2026 Australian Tour – yahoo.com

Pendulum Announces Thrilling Homecoming Tour Across Australia in 2026

September 6, 2025
HHS responds to report about autism and acetaminophen : Shots – Health News – NPR

HHS Addresses New Findings on Autism and Acetaminophen Use

September 6, 2025
September 2, 2025: Trump administration news – CNN

September 2, 2025: Trump administration news – CNN

September 6, 2025
Blending art, culture and native plants at Wakamatsu – Mountain Democrat

Discover the Harmony of Art, Culture, and Native Plants at Wakamatsu

September 6, 2025
The Two-Body Problem for Women in Science – Nautilus | Science Connected

The Two-Body Problem for Women in Science – Nautilus | Science Connected

September 6, 2025
How AI and Automation are Speeding Up Science and Discovery – Berkeley Lab News Center (.gov)

How AI and Automation Are Accelerating Breakthroughs in Scientific Discovery

September 6, 2025

American Trust Investment Services Serves as Exclusive Placement Agent in $9 Million Follow-On Offering for Nova LifeStyle, Inc. – Morningstar

September 6, 2025
Coherent Joins LLNL’s STARFIRE Diode Technology Working Group to Advance Inertial Fusion Energy – GlobeNewswire

Coherent Partners with LLNL’s STARFIRE Team to Drive Breakthroughs in Inertial Fusion Energy

September 6, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (809)
  • Economy (828)
  • Entertainment (21,705)
  • General (16,884)
  • Health (9,869)
  • Lifestyle (840)
  • News (22,149)
  • People (829)
  • Politics (835)
  • Science (16,038)
  • Sports (21,326)
  • Technology (15,808)
  • World (809)

Recent News

Abby Dow and England near record territory as Australia search for upset – The Guardian

Abby Dow and England Close in on Record as Australia Hunts for an Upset

September 6, 2025
America is getting the economy we voted for – Noah Smith | Substack

America Is Finally Experiencing the Economy We Created

September 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version