* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 7, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Blood Biomarker Panel May Predict PD Years in Advance

June 19, 2024
in Health
Blood Biomarker Panel May Predict PD Years in Advance
Share on FacebookShare on Twitter

A panel of eight blood biomarkers may be able to identify which patients will go on to develop Parkinson’s disease (PD) up to 7 years before the development of motor symptoms or dementia with Lewy bodies, results of a new study suggest.

The search for a test to diagnose PD reached a milestone recently with the arrival of alpha-synuclein seed amplification assays, hailed as potential game-changer because of their high performance as a diagnostic biomarker.

However, these assays rely on cerebrospinal fluid, cannot track changes longitudinally, and haven’t been sufficiently linked to the underlying pathophysiology, said first author Michael Bartl, MD, Department of Neurology, University Medical Center Goettingen, Germany.

“This is a big step because for the first time we are working with peripheral fluids and have a test that can predict something in an objective way,” he told Medscape Medical News. “Our panel of proteins is also more dynamic and involves the pathophysiology.”

The study was published online June 18 in Nature Communications.

Discovery and Validation Phases

For the study, the researchers performed a proteomics analysis of plasma using mass spectrometry that identified 1238 proteins in 10 randomly selected drug-naive patients with PD and 10 matched healthy controls from the de novo PD cohort. 

They then constructed a targeted, mass spectrometry proteomic assay with 121 proteins and applied it to plasma samples from 99 patients with de novo PD and 36 healthy controls, and then validated the assay in 41 patients with other neurologic diseases and in 18 patients with premotor isolated REM sleep behavior disorder (iREM).

The assay identified 23 distinct proteins involved in inflammatory pathways, Wnt-signaling, and coagulation cascade that were consistently dysregulated in patients with PD compared with healthy controls. Six of these proteins were also shown to be dysregulated in patients with iREM, reported Bartl, co–first author Jenny Hällqvist, PhD, Great Ormond Street Hospital, London, United Kingdom, and colleagues.

Finally, after refining the assay, the researchers applied a machine-learning model and analyzed an additional set of 146 longitudinal blood samples from an independent cohort of 54 persons with iRBD and follow-up sampling of up to 7 years. 

The model included eight proteins: GRN, MASP2, HSPA5, PTGDS, ICAM1, complement C3, DKK3, and SERPING1.

The model was able to identify 100% of the patients with PD based on the expression of the eight proteins and predict with 79% accuracy which patients with iREM would convert to PD up to 7 years before the onset of motor symptoms. 

“We know that isolated REM sleep disorder is a strong predictor of the disease and we wanted to see if maybe there is something in common,” Bartl said. “And to our surprise, they had a lot in common with the patients with Parkinson’s. It’s not just that they are at risk, but they already have blood that indicates the pathological processes in Parkinson’s disease have already taken place.”

Of note, most of the markers also robustly correlated with clinical scores on the Unified Parkinson’s Disease Rating Scale and Mini-Mental State Examination. 

‘Amazing Study’

Reached for comment, Chan-Hyun Na, PhD, Department of Neurology, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, said that “this is quite an amazing study because diagnosis of Parkinson’s disease using biomarkers is actually quite challenging, especially compared to other diseases.”

“My lab and my collaborators have been working on discovering Parkinson’s biomarkers using cerebral spinal fluid, but we found it is quite challenging,” he said. “But what [these researchers] found is they could discover some biomarkers from serum. This is much easier to get samples from patients and less invasive. Then, they could even predict Parkinson’s up to 7 years before the motor symptom onset. So, I think it is a quite an impressive study.”

“Blood tests for Parkinson’s for diagnosis and prediction remain a massive unmet need,” Ray Chaudhuri, MBBS, MD, professor of neurology/movement disorders at King’s College Hospital and King’s College London and medical director of the Parkinson Foundation International Centre of Excellence at King’s College London, United Kingdom, said in a statement.

“If replicated in larger studies, these tests or panel may prove to be invaluable in supporting the diagnosis of Parkinson, which work from our Centre and others have shown is a syndrome and not a single disease,” he added. “Questions, however, remain about the ethics of predictive diagnosis in relation to proper counseling as well as absence, currently, of any disease-modifying treatment.”

Bartl said that his team hopes to validate the findings in a larger cohort of at least 100 patients and also noted that the ability to identify patients with early PD could lead to greater recruitment in preventative clinical trials and potentially improve treatment options. For example, drugs can modify Wnt-signaling pathways in oncology thus may be of interest to the PD field.

The study was funded by the Michael J. Fox Foundation, PDUK, The Peto Foundation, The TMSRG (UCL), The BRC at Great Ormond Street Hospital, and the Horizon 2020 Framework Programme. Bartl has received funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation). Hällqvist reports no competing financial interests. Other co-author disclosures are listed in the paper. Na and Chaudhuri report having no conflicts to declare. 

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/blood-biomarker-panel-may-predict-parkinsons-years-advance-2024a1000bck

Tags: Biomarkerbloodhealth
Previous Post

New Pneumococcal Vaccine Approved

Next Post

Psoriasis: Features That May Affect Biologic Rx Outcomes

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

October 7, 2025
Downtown St. Paul’s economy showing new life after state employees mandated to return to office – 5 EYEWITNESS NEWS

Downtown St. Paul Thrives Again as State Employees Return to the Office

October 7, 2025
No, Anthony Boyle Didn’t Use a Prosthetic in His House of Guinness Bath Scene – Yahoo

Anthony Boyle Opens Up About the Shocking Truth Behind His House of Gucci Bath Scene

October 7, 2025
Ozzy Osbourne documentary reveals agonizing health struggles of his final years – USA Today

Inside Ozzy Osbourne’s Heartbreaking Battle with Health in His Final Years

October 7, 2025
Latino leaders explore the role community organizing can play in national politics – OSV News

Latino Leaders Unite to Amplify Community Power and Drive National Change

October 7, 2025
Ecology blazing the trail for more clean energy projects – Washington State Department of Ecology (.gov)

How Ecology is Powering the Shift to a Greener Energy Future

October 7, 2025
Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

October 7, 2025
UNESCO and CODATA launch resources on open science for crisis response – unesco.org

UNESCO and CODATA Launch Innovative Open Science Tools to Enhance Crisis Response

October 7, 2025
New Engen Report Identifies Key Trends and Winning Strategies for Active Lifestyle Brands in 2025 and Beyond – Fitt Insider

New Engen Report Identifies Key Trends and Winning Strategies for Active Lifestyle Brands in 2025 and Beyond – Fitt Insider

October 7, 2025
ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

October 7, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (855)
  • Economy (876)
  • Entertainment (21,749)
  • General (17,457)
  • Health (9,918)
  • Lifestyle (888)
  • News (22,149)
  • People (877)
  • Politics (887)
  • Science (16,086)
  • Sports (21,376)
  • Technology (15,856)
  • World (859)

Recent News

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

October 7, 2025
Downtown St. Paul’s economy showing new life after state employees mandated to return to office – 5 EYEWITNESS NEWS

Downtown St. Paul Thrives Again as State Employees Return to the Office

October 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version