* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, June 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

BRAF-MEK Inhibition Achieves ‘Near Universal’ Response in Rare Brain Tumor

July 12, 2023
in Health
BRAF-MEK Inhibition Achieves ‘Near Universal’ Response in Rare Brain Tumor
Share on FacebookShare on Twitter

alternative text

Targeted BRAF-MEK inhibition resulted in a response in nearly all patients with untreated BRAF V600E–mutated papillary craniopharyngioma, according to results from a small phase II study.

Of 16 evaluable patients treated with the BRAF inhibitor vemurafenib (Zelboraf) and the MEK inhibitor cobimetinib (Cotellic) over several monthly cycles, 15 had a durable, objective partial response or better to therapy, with a median reduction in tumor volume of 91%, reported Priscilla Brastianos, MD, of the Massachusetts General Hospital Cancer Center in Boston, and colleagues.

The one patient who did not respond received treatment for 8 days before stopping therapy due to anaphylaxis and acute kidney injury.

“Thus, all the patients who completed at least one cycle of therapy had a response to BRAF–MEK inhibition within 4 months after starting the combination regimen,” Brastianos and colleagues reported in the New England Journal of Medicine.

In addition, estimated progression-free survival was 87% at 12 months and 58% at 24 months. Overall survival was 100% at both time points.

With a median follow-up of 22 months, an estimated 93% of patients continued to have a volumetric response at 12 months. In three patients who had had a response, progressive disease developed during the follow-up period after therapy had been discontinued.

“The near-universal radiographic response with subsequent long-term stability that was seen in this study supports a shift in clinical guidelines toward biopsy and molecular analysis followed by upfront drug therapy for newly diagnosed BRAF V600E papillary craniopharyngiomas,” wrote Jaishri Blakeley, MD, of the Johns Hopkins School of Medicine in Baltimore, and Kevin Shannon, MD, of the University of California, San Francisco, in an accompanying editorial.

“The marked reduction in gross target volumes for radiation therapy after the use of vemurafenib–cobimetinib further suggests that initial drug therapy may improve clinical outcomes by reducing the radiation field or making complete surgical excision feasible,” they continued.

Craniopharyngioma is a rare and difficult-to-treat histologically benign, but locally aggressive, epithelial tumor. The location of the tumor — at the base of the brain near the optic nerve and pituitary gland — means complete resection of the tumor is usually not feasible. Treatment with radiation therapy is frequently used as an adjunct therapy to improve local control after surgery.

“No effective medical treatment for craniopharyngioma is known,” however, as treatment with surgery, radiation, or both “is often associated with substantial morbidity related to vision loss, neuroendocrine dysfunction, and memory loss,” Brastianos and colleagues pointed out. “These cumulative and debilitating long-term neurologic complications can have a substantial psychosocial effect on patients, rendering many unable to work or to live independent lives.”

They noted that genotyping shows that more than 90% of papillary craniopharyngiomas carry a BRAF V600E mutation, and that therapies that inhibit BRAF and MEK have been approved by the FDA for treating melanoma and other cancers. Thus, they hypothesized that a BRAF-MEK inhibitor (vemurafenib/cobimetinib) might also be effective for treating papillary craniopharyngioma.

In this study, eligible patients had histologically proven BRAF V600E–mutant papillary craniopharyngiomas, had not undergone previous radiation or systemic therapy for craniopharyngioma, and had measurable disease. Their median age was 49.5 years, median baseline tumor volume was 2.75 cm, and 15 of the 16 had an ECOG performance status of 0 or 1.

Patients received vemurafenib at a dose of 960 mg orally twice daily for 28 days in combination with cobimetinib at a dose of 60 mg orally once daily for 21 days. Protocol dictated that patients undergo radiation or surgery after treatment with vemurafenib-cobimetinib for four cycles, but many were permitted to continue BRAF-MEK inhibition until the occurrence of documented progression, unacceptable adverse events, or withholding of drug therapy for longer than 28 days.

Regarding safety, three patients discontinued therapy due to adverse events (median treatment duration of 31 days).

Twelve patients had a grade 3 adverse event, with rash, dehydration, increase in alkaline phosphatase levels, and prolongation of the corrected QT interval observed in two or more patients.

Two patients had grade 4 adverse events considered to be “at least possibly related” to treatment, including an increase in the creatine kinase level, and a case of hyperglycemia.

In their editorial, Shannon and Blakeley suggested that while the range of toxic effects reported here were similar to those seen in other studies of BRAF-MEK inhibitors, “the incidence of adverse events in this study is problematic for long-term daily therapy for an indolent, histologically benign tumor.”

Therefore, they added, an important question is whether dual inhibition is necessary to induce papillary craniopharyngioma regression.

Brastianos and colleagues acknowledged that it remains “an open question” whether BRAF-MEK inhibition is indicated for a therapeutic response or whether BRAF inhibition alone is sufficient.

“We chose the combination, given the improved progression-free and overall survival observed with the use of combination BRAF-MEK inhibitors in other tumor types, as well as the concerning rate of specific toxic side effects, such as proliferative skin lesions, that have been seen with BRAF monotherapy,” they explained.

The authors cautioned that their study lacked a control group and had a small sample due to the rarity of the disease. Uncertainties also remain regarding the ideal duration of BRAF-MEK inhibition and its effectiveness in patients with recurrent craniopharyngioma after radiation.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

This study was funded by the National Cancer Institute and others.

Brastianos reported relationships with Advise Connect Inspire, AstraZeneca, Bristol-Myers Squibb, Dantari Elevate Bio, Eli Lilly, Genentech, GlaxoSmithKline, Kazia, Merck, Mirati, MPM Capital, Pfizer, Sintetica, SK Life Science, Voyager.

Blakeley reported serving on the medical advisory board of SpringWorks Therapeutics.

Shannon reported relationships with AbbVie, Ambagon, Genentech, Plexxikon.

Primary Source

New England Journal of Medicine

Source Reference: Brastianos P, et al “BRAF-MEK inhibition in newly diagnosed papillary craniopharyngiomas” N Engl J Med 2023; DOI: 10.1056/NEJMoa2213329.

Secondary Source

New England Journal of Medicine

Source Reference: Blakeley J, Shannon K “Precision oncology for papillary craniopharyngioma” N Engl J Med 2023: DOI: 10.1056/NEJMe2305288.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/braincancer/105446

Tags: BRAF-MEKhealthInhibition
Previous Post

The Key to Fighting Antimicrobial Resistance? Dollars, Experts Say

Next Post

The 5 Most Common Delusions Worldwide

Collective dynamical regimes predict invasion success and impacts in microbial communities – Nature

Collective dynamical regimes predict invasion success and impacts in microbial communities – Nature

June 4, 2025
John Brenkus, ‘Sport Science’ Host, Died By Suicide, Medical Examiner Says – TMZ

Tragic Loss: ‘Sport Science’ Host John Brenkus Passes Away in Heartbreaking Circumstances

June 4, 2025
Meghan to take a break from As ever as she announces next step for those ‘wondering and waiting’ – Nine – Honey

Meghan to take a break from As ever as she announces next step for those ‘wondering and waiting’ – Nine – Honey

June 4, 2025
Aeternum Update 1.3.27 – newworld.com

Exciting New Features and Enhancements in Aeternum Update 1.3.27!

June 4, 2025
Larry Kudlow: Liberal media has been ‘completely wrong’ on the Trump economy – Fox Business

Larry Kudlow: Liberal media has been ‘completely wrong’ on the Trump economy – Fox Business

June 4, 2025
Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

June 4, 2025
Hochul, Jeffries raise concerns over possible impacts of One Big Beautiful Bill Act – Spectrum News

Hochul, Jeffries raise concerns over possible impacts of One Big Beautiful Bill Act – Spectrum News

June 4, 2025
Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

June 4, 2025
Kehoe calls special session on storm damage, KC sports teams – FOX 2

Kehoe Announces Special Session to Address Storm Damage and Support KC Sports Teams

June 3, 2025
From Eggs To Fingerlings, Wyoming Students Dive Into The World Of Fish Conservation – KGAB

From Eggs to Fingerlings: Wyoming Students Make Waves in Fish Conservation!

June 3, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (664)
  • Economy (678)
  • Entertainment (21,584)
  • General (15,261)
  • Health (9,720)
  • Lifestyle (681)
  • News (22,149)
  • People (679)
  • Politics (687)
  • Science (15,898)
  • Sports (21,182)
  • Technology (15,664)
  • World (665)

Recent News

Collective dynamical regimes predict invasion success and impacts in microbial communities – Nature

Collective dynamical regimes predict invasion success and impacts in microbial communities – Nature

June 4, 2025
John Brenkus, ‘Sport Science’ Host, Died By Suicide, Medical Examiner Says – TMZ

Tragic Loss: ‘Sport Science’ Host John Brenkus Passes Away in Heartbreaking Circumstances

June 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version