* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, August 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Brain cancer linked to nuclear pore alterations

September 15, 2023
in Health
Brain cancer linked to nuclear pore alterations
Share on FacebookShare on Twitter

Brain cancer linked to nuclear pore alterations

We identify nuclear pore protein NUP107 as a significantly amplified and overexpressed gene with MDM2 which mediating p53 protein degradation in Glioblastoma. Loss of NUP107 causes reactivation of the p53 pathway by stabilizing protein amounts of p53. These findings provide a new noncanonical regulation of p53 at spatial levels in Glioblastoma. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112882

Several types of cancer are believed to be linked to alterations of macromolecular structures known as nuclear pore complexes (NPCs). These structures are embedded in the nuclear envelope, a membrane barrier that separates the nucleus of a cell from the cytoplasm (the liquid filling the rest of the cell). They consist of proteins called nucleoporins, which regulate the transport of molecules across the nuclear envelope, including enzymes that enable the synthesis of DNA. Whether NPC alterations play a role in glioblastoma, the most common type of cancer originating in the brain, is unclear at the moment.

Now, Masaharu Hazawa, Mitsutoshi Nakada and Richard Wong and from Kanazawa University and colleagues have found a link between the functioning of NPCs and glioblastoma—specifically, they demonstrated the inactivation of a tumor-suppressing protein called p53. Their research is published in Cell Reports.

The protein p53 is crucial in cancer prevention. The corresponding gene TP53 encodes proteins that prevent mutations of the genome and is the most frequently mutated gene in human cancers. Gaining insights into how p53 inactivation happens is crucial for understanding tumorigenesis in general and glioblastoma in particular.

Nakada and Wong and colleagues first checked whether any nuclear pore complex proteins were amplified (“overexpressed”) in glioblastoma. They found that one such protein, called NUP107, showed overexpression. Further investigations revealed that NUP107 is a potential oncoprotein in glioblastoma; its overexpression degrades the function of the cancer-suppressing p53 protein. They also found that MDM2, another protein, is overexpressed simultaneously with NUP107. MDM2 is also known to mediate p53 protein degradation.

Further studies will be necessary to uncover the full molecular pathways at play, but the scientists speculate that the increased amount of NUP107 proteins in the NPCs of glioblastoma cells results in NPC structures that regulate the transport of molecules from the nucleus to the cytoplasm in a way that promotes p53 degradation. This scenario is referred to as nuclear transport surveillance. Experiments in which NUP107 proteins were depleted re-activated p53, consistent with NUP107 providing structural stability of glioblastoma NPCs.

The findings of Nakada and Wong and colleagues confirm that alterations of NPCs contribute to the pathogenesis of glioblastoma. The researchers state, “Together, our findings establish roles of NPCs in transport surveillance and provide insights into p53 inactivation in glioblastoma.”

More information:
Dini Kurnia Ikliptikawati et al, Nuclear transport surveillance of p53 by nuclear pores in glioblastoma, Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112882

Citation:
Brain cancer linked to nuclear pore alterations (2023, September 15)
retrieved 15 September 2023
from https://medicalxpress.com/news/2023-09-brain-cancer-linked-nuclear-pore.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-09-brain-cancer-linked-nuclear-pore.html

Tags: BrainCancerhealth
Previous Post

Bangladesh is struggling to cope with a record dengue outbreak in which 778 people have died

Next Post

MRI observation of human embryos at a one-hundredth-of-millimeter resolution

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

August 2, 2025
EPA attacks climate science. Here are the facts. – E&E News by POLITICO

EPA Questions Climate Science: Key Insights You Shouldn’t Miss

August 2, 2025
6 science-backed strategies to improve your memory – National Geographic

6 Proven Science-Backed Strategies to Boost Your Memory

August 2, 2025
Trying to keep your brain young? A big new study finds these lifestyle changes help – NPR

Trying to keep your brain young? A big new study finds these lifestyle changes help – NPR

August 2, 2025
2025 World Junior Summer Showcase: 3 things learned on Day 5 – NHL.com

3 Must-Know Highlights from Day 5 of the 2025 World Junior Summer Showcase

August 2, 2025
Economic Reality Bites Trump and His Protectionist Trade Policies – The New Yorker

How Trump’s Protectionist Trade Policies Ended Up Hurting the Global Economy

August 2, 2025
Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

August 2, 2025
President Trump Delivers Remarks on Making Health Technology Great Again – The White House (.gov)

President Trump Delivers Remarks on Making Health Technology Great Again – The White House (.gov)

August 2, 2025
Trump’s super PAC in powerful financial position with nearly $200 million on hand – CNN

Trump’s super PAC in powerful financial position with nearly $200 million on hand – CNN

August 2, 2025
It’s time to retire the word ‘technology’ – Financial Times

Why It’s Time to Retire the Word ‘Technology’ for Good

August 2, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (750)
  • Economy (775)
  • Entertainment (21,653)
  • General (16,241)
  • Health (9,812)
  • Lifestyle (783)
  • News (22,149)
  • People (776)
  • Politics (784)
  • Science (15,988)
  • Sports (21,270)
  • Technology (15,752)
  • World (758)

Recent News

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

August 2, 2025
EPA attacks climate science. Here are the facts. – E&E News by POLITICO

EPA Questions Climate Science: Key Insights You Shouldn’t Miss

August 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version