* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, June 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Revolutionary Harvesting Technology Promises to Slash CAR-T Manufacturing Costs!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Revolutionary Harvesting Technology Promises to Slash CAR-T Manufacturing Costs!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

C. elegans study finds mRNA balance in cells influences lifespan

June 21, 2024
in Health
C. elegans study finds mRNA balance in cells influences lifespan
Share on FacebookShare on Twitter

How to make ageing a 'fairer game' for all wormkind

Composite image showing fluorescent-tagged nuclei in every cell of five different C. elegans captured in the Advanced Light Microscopy Unit at the CRG. Credit: Jeremy Vicencio, Nadia Halidi/Centro de Regulación Genómica

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

Exploring how aging is influenced at the molecular level could shed light on lifespan variation, but generating data at the speed, scale and quality necessary to study this in humans is unfeasible. Instead, researchers turn to worms (Caenorhabditis elegans). Humans share a lot of biology with these small creatures, who also have a large, natural variation in lifespan.

Researchers at the Center for Genomic Regulation (CRG) observed thousands of genetically identical worms living in a controlled environment. Even when diet, temperature and exposure to predators and pathogens are the same for all worms, many individuals continue to live for a longer or shorter period of time than the average.

The study traced the primary source of this variation to changes in the mRNA content in germline cells (those involved in reproduction) and somatic cells (the cells forming the body). The mRNA balance between the two types of cells is disrupted, or “decouples,” over time, causing aging to run faster in some individuals than others. The findings are published today in the journal Cell.

Older worm (left) vs. younger worm (right). The younger worm displays more signs of active, vigorous movement, an indicator used by the researchers to assess its healthspan. Credit: Andrea del Carmen Fabregat/Centro de Regulación Genómica

The study also found that the magnitude and speed of the decoupling process is influenced by a group of at least 40 different genes. These genes play many different roles in the body, ranging from metabolism to the neuroendocrine system. However, the study is the first to show they all interact to make some individuals live longer than others.

Knocking down some of the genes extended a worm’s lifespan, while knocking down others shortened it. The findings suggest a surprising possibility: the natural differences seen in aging worms might reflect randomness in the activity of many different genes, making it look as if individuals have been exposed to knockdowns of many different genes.

“Whether a worm lives to day 8 or day 20 is down to seemingly random differences in the activity of these genes. Some worms appear to be simply lucky, in that they have the right mix of genes activated at the right time,” says Dr. Matthias Eder, first author of the paper and researcher at the Center for Genomic Regulation.

Knocking down three genes—aexr-1, nlp-28, and mak-1—had a particularly dramatic effect on lifespan variance, reducing the range from around 8 days to just 4. Rather than prolonging the lives of all individuals uniformly, removing any one of these genes drastically increased the life expectancy of worms on the low end of the spectrum, while the life expectancies of the longest-lived worms remained more or less unchanged.

How to make ageing a 'fairer game' for all wormkind

C. elegans pictured in normal color conditions under a microscope. Credit: Jeremy Vicencio, Nadia Halidi/Centro de Regulación Genómica

The researchers observed the same effects on health span, the period of life spent healthy, rather than simply how long an individual is physically alive. The researchers measured this by studying how long the worms maintain vigorous movement. Knocking down just one of the genes was enough to disproportionately improve healthy aging in worms on the low end of the health span spectrum.

“This isn’t about creating immortal worms, but rather making aging a more equitable process than it currently is—a fairer game for all. In a way, we’ve been doing what doctors do, which is take worms that would die sooner than their peers and make them healthier, helping them live closer to their maximum potential life expectancy. But we’re doing it by targeting basic biological mechanisms of aging, not just treating sick individuals. It’s essentially making a population more homogeneous and more long lived to boot,” says Dr. Nick Stroustrup, senior author of the study and Group Leader at the Center for Genomic Regulation.

The study doesn’t address why knocking down the genes doesn’t seem to negatively affect the worm’s health.

“Several genes could interact to provide built-in redundancy after a certain age. It could also be that the genes aren’t needed for individuals living in benign, safe conditions where the worms are kept in the lab. In the harsh environment of the wild, these genes might be more critical for survival. These are just some of the working theories,” says Dr. Eder.

The researchers made their findings by developing a method which measures RNA molecules in different cells and tissues, combining it with the “Lifespan Machine,” a device which follows the entire lives of thousands of nematodes at once. The worms live in a petri dish housed inside the machine under the watchful eye of a scanner.

The device images nematodes once per hour, gathering lots of data about their behavior. The researchers have plans to build a similar machine to study the molecular causes of aging in mice, which have a biology that more closely resembles that of humans.

More information:
Matthias Eder et al, Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony, Cell (2024). DOI: 10.1016/j.cell.2024.05.050

Journal information:
Cell

Citation:
C. elegans study finds mRNA balance in cells influences lifespan (2024, June 21)
retrieved 21 June 2024
from https://medicalxpress.com/news/2024-06-elegans-mrna-cells-lifespan.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-06-elegans-mrna-cells-lifespan.html

Tags: eleganshealthstudy
Previous Post

How to Actually Promote Diversity, Equity and Inclusion in the Workplace

Next Post

Research suggests potential targets for prevention and early identification of psychotic disorders

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

June 2, 2025
‘Amazing Worlds of Science Fiction and Science Fact’ Review: An Education in Exoplanets – WSJ

Exploring the Fascinating Realms of Science Fiction and Fact: A Journey Through Exoplanets

June 2, 2025
2-Year-Old Prodigy Joins ‘High IQ’ Club Mensa as Youngest Member Ever – ScienceAlert

Meet the 2-Year-Old Prodigy Who Just Became Mensa’s Youngest Member Ever!

June 2, 2025
Labubu Fever Ignites a Global Craze for Lifestyle and Investment – iChongqing

Labubu Fever Ignites a Global Craze for Lifestyle and Investment – iChongqing

June 2, 2025
Erin Hills ‘dominates’ Nelly Korda at U.S. Women’s Open, where she finished second – Golfweek

Nelly Korda Falls Short at U.S. Women’s Open as Erin Hills Takes Center Stage

June 2, 2025
Economy Shrank Less Than Previously Thought in First Quarter – Investopedia

Economy Shrank Less Than Previously Thought in First Quarter – Investopedia

June 2, 2025
Rising stars: Young classical musicians surging on social media – Yahoo

Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

June 2, 2025
Medicaid work rules could leave a million Californians with no health insurance – CalMatters

California’s Medicaid Work Rules: A Million Residents at Risk of Losing Health Coverage!

June 2, 2025
Texas Democrat Beto O’Rourke returns to Houston area for another town hall – Houston Public Media

Beto O’Rourke Makes a Comeback: Join Him for an Engaging Town Hall in Houston!

June 2, 2025
In Indore, Alstom’s advanced metro train and CBTC signalling technology transform urban mobility as revenue service commences – Alstom

Revolutionizing Urban Mobility: Alstom Launches Advanced Metro Train and Cutting-Edge Signalling Technology in Indore

June 2, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (659)
  • Economy (673)
  • Entertainment (21,580)
  • General (15,256)
  • Health (9,716)
  • Lifestyle (676)
  • News (22,149)
  • People (675)
  • Politics (682)
  • Science (15,894)
  • Sports (21,178)
  • Technology (15,660)
  • World (661)

Recent News

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

June 2, 2025
‘Amazing Worlds of Science Fiction and Science Fact’ Review: An Education in Exoplanets – WSJ

Exploring the Fascinating Realms of Science Fiction and Fact: A Journey Through Exoplanets

June 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version