* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, September 29, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Can a vitamin transform natural killer cells into a cancer therapy? Scientists think the answer is yes

September 17, 2023
in Health
Can a vitamin transform natural killer cells into a cancer therapy? Scientists think the answer is yes
Share on FacebookShare on Twitter

Can a vitamin transform natural killer cells into a cancer therapy? Scientists think the answer is yes

NAM does not impact activation-induced cleavage of CD62L. NK cells enriched from the peripheral blood of 4 healthy donors were cultured overnight in the indicated culture conditions. Cells were then collected and analyzed by flow cytometry to assess surface CD16 and CD62L. Shown are representative flow cytometry plots (top) and cumulative data from all 4 donors (bottom). Credit: Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.ade3341

Cancer patients appeared to benefit from natural killer cells obtained from donors in an experimental method of treating cancer that involved an aggressive army of immune system fighters endowed with the ability to home in on malignant cells and destroy them.

The natural killer cells were pre-treated with nicotinamide, a compound widely known to most people as niacin, or vitamin B3. It’s a substance with a special affinity for natural killer cells, enhancing their capacity to annihilate cancers. Once primed in the laboratory, these natural killers are ready to be unleashed against formidable targets. The evolving methodology has shown promise in a preliminary study aimed at forcing hard-to-treat cancers of the blood into remission.

Prior to the new research, which is published in Science Translational Medicine, attempts by other teams to use natural killer cell infusions as a therapeutic for leukemias, lymphomas and other blood malignancies, weren’t always effective. Doctors were confronted with a problem: some people simply didn’t respond to the investigational treatment, which was offered after standard therapy failed.

Now, in a unique take on this emerging form of cancer treatment, medical scientists in the Division of Hematology, Oncology and Transplantation at the University of Minnesota, have devised a way to boost the effectiveness of natural killer cells, enhancing their role as a therapeutic. The innovative approach boosted the impact of natural killer cells and brought about remissions in patients with otherwise recalcitrant cancers.

“Allogeneic natural killer cell adoptive transfer has shown the potential to induce remissions in relapsed or refractory leukemias and lymphomas,” writes Dr. Frank Cichocki and colleagues in the journal. “Strategies to enhance natural killer cell survival and function are needed to improve clinical efficacy. We demonstrated that natural killer cells cultured ex vivo with interleukin-15—IL-15—and nicotinamide exhibited stable induction of l-selectin, a lymphocyte adhesion molecule important for lymph node homing.”

Nicotimamide helps the body turn food into energy and is chemically part of the coenzymes NAD+ and NADH, which are critical in oxidation-reduction reactions throughout the body. Among these activities is the production of adenosine triphosphate, ATP, which fuels cellular and metabolic processes.

In 1937, researchers discovered that the systemic disease known as pellegra is caused by a niacin deficiency. The disorder is typified by the three D’s—dementia, diarrhea and dermatitis. Without treatment, which is simply providing niacin, pellegra can be fatal.

The team’s choice of nicotinamide as an enhancer of natural killer cells shines a spotlight on the common water-soluble compound and demonstrates how it can boost the anti-cancer activity of natural killer cells. These cells are lymphocytes and members of the innate immune system, the body’s first response to invasive disease. Natural killer cells’ job is helping control cancer and invasive microbes.

Scientists, meanwhile, who are developing the experimental therapy have merely boosted these cells to help them attack cancers more efficiently. If further testing proves this method effective—and the Minneapolis-based scientists are convinced they’re on the right track—then an innovative new approach to treating cancers of the blood will emerge.

“We conducted a first-in-human phase 1 clinical trial testing adoptive transfer of natural killer cells expanded ex vivo with IL-15 and nicotinamide combined with monoclonal antibodies in patients with relapsed or refractory non-Hodgkin lymphoma and multiple myeloma,” Cichocki asserted in Science Translational Medicine.

In the small preliminary study, Cichocki and collaborators found that nicotinamide not only enhances the activity of natural killer cells but boosts their persistence in the blood and bolsters the capability of these cells not only to hunt down cancer cells, but to handily destroy them.

The combination of nicotinamide-enhanced natural killer cells and monoclonal antibody treatment was safe in 30 patients, including 20 with relapsed or difficult-to-treat non-Hodgkin lymphoma. Among 19 patients with non-Hodgkin lymphoma, 11 demonstrated a complete response and three had a partial response within 28 days of treatment. Nicotinamide appears to protect the natural killer cells from oxidative stress, while enhancing their ability to home in on lymph nodes, the team found.

“High frequencies of CD62L were associated with elevated transcription factor forkhead box O1, or FOXO1,” Cichocki noted, referring to the homing molecule, CD62L, which shepherds natural killer cells to the lymph nodes. As a transcription factor, FOXO1 is responsible regulating a broad number of genes involved in metabolism, cell cycle progression and programmed cell death.

In cancers, FOXO1 acts as a suppressor of malignant cells mainly because of its roles promoting programmed cell death—apoptosis—and inhibiting cell cycle progression, angiogenesis and metastasis.

“Nicotinamide promoted the stability of FOXO1 by preventing proteasomal degradation,” Cichocki lead author of the study added. “Natural killer cells cultured with nicotinamide exhibited metabolic changes associated with elevated glucose flux and protection against oxidative stress.”

Natural killer cells treated with nicotinamide in the lab also demonstrated an increased ability to generate an inflammatory and toxic response against cancer cells. Cichocki and colleagues concluded that their findings suggest the new transfer strategy should be studied further in larger clinical trials.

More information:
Frank Cichocki et al, Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma, Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.ade3341

© 2023 Science X Network

Citation:
Can a vitamin transform natural killer cells into a cancer therapy? Scientists think the answer is yes (2023, September 16)
retrieved 16 September 2023
from https://medicalxpress.com/news/2023-09-vitamin-natural-killer-cells-cancer.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-09-vitamin-natural-killer-cells-cancer.html

Tags: healthTransformVitamin
Previous Post

Choking hazard spurs recall of bath toys sold at target

Next Post

Neonatal kidney transplantation offers new hope in the organ shortage crisis, study shows

Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

September 29, 2025
Governor calls on Congress to extend tax credits to protect affordable health care coverage – NKyTribune

Governor Calls on Congress to Extend Tax Credits and Protect Affordable Health Care Coverage

September 29, 2025
CNN anchor questions Speaker Johnson about potential government shutdown – CNN

CNN Anchor Challenges Speaker Johnson on Looming Government Shutdown

September 29, 2025
Neighborhood Ecology Corps – RaleighNC.gov

Uncover How the Neighborhood Ecology Corps is Transforming Raleigh

September 28, 2025
A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

September 28, 2025
The right stuff: New cohort of astronauts recruited by NASA – Digital Journal

The right stuff: New cohort of astronauts recruited by NASA – Digital Journal

September 28, 2025
‘Fallapalooza’ encourages active lifestyle for senior safety – WVIR

Fallapalooza Ignites Senior Spirit for Active and Safe Living

September 28, 2025
Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

September 28, 2025
While chasing DK Metcalf, Isaiah Rodgers reached unprecedented speed – Yahoo Sports

Isaiah Rodgers Hits Unbelievable Top Speed While Chasing Down DK Metcalf

September 28, 2025
Poland bounce back with first ever World Championship bronze – Volleyball World

Poland Triumphs with Historic First-Ever World Championship Bronze in Volleyball

September 28, 2025

Categories

Archives

September 2025
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (842)
  • Economy (862)
  • Entertainment (21,737)
  • General (17,301)
  • Health (9,906)
  • Lifestyle (875)
  • News (22,149)
  • People (864)
  • Politics (873)
  • Science (16,072)
  • Sports (21,362)
  • Technology (15,845)
  • World (844)

Recent News

Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

September 29, 2025
Governor calls on Congress to extend tax credits to protect affordable health care coverage – NKyTribune

Governor Calls on Congress to Extend Tax Credits and Protect Affordable Health Care Coverage

September 29, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version