* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, September 8, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    The Secret to What Made ‘CarJack’ Work on As the World Turns – yahoo.com

    The Surprising Secret Behind ‘CarJack’s’ Success on As the World Turns

    Victor Garber on his viral “And Just Like That” toilet scene: ‘I was delighted to be doing something ridiculous’ (exclusive) – yahoo.com

    Victor Garber on his viral “And Just Like That” toilet scene: ‘I was delighted to be doing something ridiculous’ (exclusive) – yahoo.com

    Pendulum Announce Homecoming 2026 Australian Tour – yahoo.com

    Pendulum Announces Thrilling Homecoming Tour Across Australia in 2026

    ITV Studios Launches New Entertainment Label – Global Bulletin – IMDb

    ITV Studios Unveils Exciting New Entertainment Label

    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Industry partner provides Ferris State Plastics Engineering Technology students with state-of-the-art equipment to gain in-demand skills – Ferris State University

    Industry Partner Equips Ferris State Plastics Engineering Students with Cutting-Edge Technology to Boost In-Demand Skills

    Health Technology Ecosystem – Centers for Medicare & Medicaid Services | CMS (.gov)

    Discover the Future of Health Technology: Innovations Revolutionizing Patient Care

    Coherent Joins LLNL’s STARFIRE Diode Technology Working Group to Advance Inertial Fusion Energy – GlobeNewswire

    Coherent Partners with LLNL’s STARFIRE Team to Drive Breakthroughs in Inertial Fusion Energy

    Gene Associated With Deadly Heart Disease in Golden Retrievers Identified – Technology Networks

    Breakthrough Discovery Uncovers Gene Behind Deadly Heart Disease in Golden Retrievers

    Monkey Island LNG Picks ConocoPhillips’ Liquefaction Technology – Hart Energy

    Monkey Island LNG Selects ConocoPhillips’ Advanced Liquefaction Technology for Next-Gen Energy Solutions

    Credo Technology Group Holding Ltd. (CRDO) Surpasses Q1 Earnings and Revenue Estimates – Yahoo Finance

    Credo Technology Group Surpasses Q1 Earnings and Revenue Expectations

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    The Secret to What Made ‘CarJack’ Work on As the World Turns – yahoo.com

    The Surprising Secret Behind ‘CarJack’s’ Success on As the World Turns

    Victor Garber on his viral “And Just Like That” toilet scene: ‘I was delighted to be doing something ridiculous’ (exclusive) – yahoo.com

    Victor Garber on his viral “And Just Like That” toilet scene: ‘I was delighted to be doing something ridiculous’ (exclusive) – yahoo.com

    Pendulum Announce Homecoming 2026 Australian Tour – yahoo.com

    Pendulum Announces Thrilling Homecoming Tour Across Australia in 2026

    ITV Studios Launches New Entertainment Label – Global Bulletin – IMDb

    ITV Studios Unveils Exciting New Entertainment Label

    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Industry partner provides Ferris State Plastics Engineering Technology students with state-of-the-art equipment to gain in-demand skills – Ferris State University

    Industry Partner Equips Ferris State Plastics Engineering Students with Cutting-Edge Technology to Boost In-Demand Skills

    Health Technology Ecosystem – Centers for Medicare & Medicaid Services | CMS (.gov)

    Discover the Future of Health Technology: Innovations Revolutionizing Patient Care

    Coherent Joins LLNL’s STARFIRE Diode Technology Working Group to Advance Inertial Fusion Energy – GlobeNewswire

    Coherent Partners with LLNL’s STARFIRE Team to Drive Breakthroughs in Inertial Fusion Energy

    Gene Associated With Deadly Heart Disease in Golden Retrievers Identified – Technology Networks

    Breakthrough Discovery Uncovers Gene Behind Deadly Heart Disease in Golden Retrievers

    Monkey Island LNG Picks ConocoPhillips’ Liquefaction Technology – Hart Energy

    Monkey Island LNG Selects ConocoPhillips’ Advanced Liquefaction Technology for Next-Gen Energy Solutions

    Credo Technology Group Holding Ltd. (CRDO) Surpasses Q1 Earnings and Revenue Estimates – Yahoo Finance

    Credo Technology Group Surpasses Q1 Earnings and Revenue Expectations

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Carbapenems Sometimes Overused for Drug-Resistant Enterobacterales Infections

April 30, 2024
in Health
Carbapenems Sometimes Overused for Drug-Resistant Enterobacterales Infections
Share on FacebookShare on Twitter

Broad spectrum carbapenems were the most commonly used therapy for targeted treatment of extended-spectrum cephalosporin-resistant (ECR) Enterobacterales infections in U.S. hospitals, according to a retrospective cohort study.

Among over 30,000 inpatient encounters involving ECR Enterobacterales infections, 58.3% of patients received targeted treatment with carbapenems, Sameer Kadri, MD, of the NIH in Bethesda, Maryland, and colleagues reported in Lancet Infectious Diseases.

Prescribers also chose carbapenems in 45.6% of ECR Enterobacterales infections without septic shock and in 46.8% of genitourinary infections without septic shock — situations where narrower-spectrum antibiotic alternatives were potential therapeutic choices.

“Results showed a marked prescriber preference for carbapenems in microbiologically confirmed ECR Enterobacterales infections,” the authors wrote. “These findings highlight several opportunities to improve carbapenem stewardship, including for patients with mild disease manifestations and with pathogens for which other narrower-spectrum agents retain in-vitro activity.”

Among all encounters, the most frequently prescribed empirical treatments were piperacillin-tazobactam and cefepime, each prescribed in approximately 22% of encounters with patients who had ECR Enterobacterales infections.

However, carbapenems were less likely to be used as an initial empirical treatment before antimicrobial susceptibility test (AST) results were available. Carbapenems were prescribed empirically in just 17.7% of all encounters and in 19.4% of encounters involving septic shock.

“Carbapenems were used infrequently as empirical therapy in our study, and, concerningly, a proportion of patients with septic shock received empirical therapy without activity against ECR Enterobacterales,” Kadri and colleagues pointed out. “Clinicians globally still rely on probabilistic approaches for empirical antibiotic prescription.”

Of note, the transition from a non-carbapenem antibiotic to a carbapenem occurred most frequently on the date that the AST results became available, indicating that susceptibility testing drove carbapenem prescribing.

Frequent carbapenem use in U.S. hospitals predated a 2020 Infectious Diseases Society of America (IDSA) guidance document that recommended carbapenems for complicated urinary tract infections (UTIs) and pyelonephritis, as well as all other extended-spectrum ß-lactamase-producing (ESBL) infections, regardless of illness severity, Kadri and colleagues explained.

The study found no change in carbapenem use over the course of the 4-year period (adjusted OR 1.00, 95% CI 1.00-1.00), regardless of changes in IDSA recommendations, indicating that carbapenems were already in widespread use.

“This finding probably reflects the profound impact of the landmark MERINO trial, viewed from a clinical point of view, which often favors overtreating versus undertreating infections to maximize individual outcomes,” the authors wrote.

Published in 2018, the MERINO trial established that piperacillin-tazobactam was not superior to the carbapenem antibiotic meropenem for the treatment of ECR Enterobacterales infections. This finding led to the 2020 IDSA guidance update. However, in 2023, the organization issued another updated guidance document. Based on evidence from a systematic review, the guidance document dropped the recommendation of carbapenems as first-line treatment for complicated UTIs, ostensibly to reserve carbapenems for more severe infections, such as bloodstream infections or septic shock. The 2023 IDSA guidance document update now recommends the use of fluoroquinolones and trimethoprim-sulfamethoxazole for complicated UTIs.

“Rapidly changing guidance could lead to uncertainty and inertia,” commented Erika Ernst, PharmD, of the University of Iowa College of Pharmacy in Iowa City, in an accompanying editorial. “Additional efforts will be needed to increase awareness of the most recent guidance and guide implementation.”

Ernst posited that new implementation strategies “should also include principles of diagnostic stewardship, such as modifying susceptibility results by laboratories or as agreed upon by the antimicrobial stewardship team to help guide appropriate treatment.”

“Elective and cascade reporting, in which the preferred antibiotic options are shown and less desirable options are hidden or suppressed, has been shown to improve prescribing,” Ernst noted, pointing out that in the study, AST results led to changes in therapy.

The study analyzed data from the PINC AI database from 2018 to 2021 at 168 U.S. hospitals. Researchers found that over this time period, 30,041 encounters were associated with ECR Enterobacterales infection. Of these, 53.3% were in women, and patients had a mean age of 67 years.

Among patients included in the study, 54.4% had an ICD-10 diagnosis of sepsis and 34.4% required admission to the ICU. Approximately 20% required mechanical ventilation and 27% required vasopressors. Infections of the genitourinary tract accounted for approximately 54% of all infections, with bloodstream infections (17.6%) as the next most common. Escherichia coli and Klebsiella species were the most frequently isolated pathogens.

The authors noted several limitations of their analysis. Researchers relied on charge codes since laboratory data were not consistently available. COVID-19 pandemic-related factors may have altered rates of mechanical ventilation and vasopressor use, as well as selection of antibiotic therapies. Also, researchers could not discern the effect of selective reporting of susceptibility testing on prescribers’ choice of antibiotic.

author['full_name']

Katherine Kahn is a staff writer at MedPage Today, covering the infectious diseases beat. She has been a medical writer for over 15 years.

Disclosures

The study was funded by the National Institute of Allergy and Infectious Diseases and the FDA.

Kadri and co-authors disclosed no relationships with industry.

Ernst disclosed support from Merck.

Primary Source

The Lancet Infectious Diseases

Source Reference: Walker MK, et al “Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections in US hospitals and influence of IDSA guidance: a retrospective cohort study” Lancet Infect Dis 2024; DOI: 10.1016/S1473-3099(24)00149-X.

Secondary Source

The Lancet Infectious Diseases

Source Reference: Ernst EJ “Carbapenem use in US hospitals: guidance and stewardship” Lancet Infect Dis 2024; DOI: 10.1016/S1473-3099(24)00231-7.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/109883

Tags: CarbapenemshealthSometimes
Previous Post

Bumble launches global campaign and revamps visual identity

Next Post

FDA Brings Lab Tests Under Its Oversight

Six Acclaimed Artists Interpret Ecology and the Landscape for ‘Ground/work 2025’ – thisiscolossal.com

Six Acclaimed Artists Interpret Ecology and the Landscape for ‘Ground/work 2025’ – thisiscolossal.com

September 7, 2025
This Stanford computer science professor went to written exams 2 years ago because of AI. He says his students insisted on it – Fortune

Stanford Professor Returns to Written Exams After Students Demand It Amid AI Rise

September 7, 2025
Tiny thumbnails may be key for rodents’ global takeover – Science News

How Tiny Thumbnails Helped Rodents Conquer the Globe

September 7, 2025
$9 Million Stock & Warrant Deal: American Trust Leads Furniture Maker Nova LifeStyle’s Strategic Offering – Stock Titan

American Trust Fuels Nova LifeStyle’s Growth with $9 Million Stock and Warrant Investment

September 7, 2025
Industry partner provides Ferris State Plastics Engineering Technology students with state-of-the-art equipment to gain in-demand skills – Ferris State University

Industry Partner Equips Ferris State Plastics Engineering Students with Cutting-Edge Technology to Boost In-Demand Skills

September 7, 2025
Former NFL All-Pro RB has top girls basketball prospect – Yahoo Sports

Former NFL All-Pro RB has top girls basketball prospect – Yahoo Sports

September 7, 2025
Pope Leo appeals for peace in Holy Land, Ukraine, areas of world marred by war – Vatican News

Pope Leo appeals for peace in Holy Land, Ukraine, areas of world marred by war – Vatican News

September 7, 2025
The US Economy Is at a Turning Point—and the Stakes Are Higher Than You Might Think – Morningstar

The US Economy Stands at a Crucial Crossroads-Here’s Why It Matters Now More Than Ever

September 7, 2025
The Secret to What Made ‘CarJack’ Work on As the World Turns – yahoo.com

The Surprising Secret Behind ‘CarJack’s’ Success on As the World Turns

September 7, 2025
Fighting a health insurance denial? Here are 7 tips to help – Los Angeles Times

7 Powerful Strategies to Beat Health Insurance Denials and Secure the Coverage You Deserve

September 7, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (812)
  • Economy (829)
  • Entertainment (21,707)
  • General (16,910)
  • Health (9,871)
  • Lifestyle (843)
  • News (22,149)
  • People (832)
  • Politics (836)
  • Science (16,040)
  • Sports (21,329)
  • Technology (15,810)
  • World (811)

Recent News

Six Acclaimed Artists Interpret Ecology and the Landscape for ‘Ground/work 2025’ – thisiscolossal.com

Six Acclaimed Artists Interpret Ecology and the Landscape for ‘Ground/work 2025’ – thisiscolossal.com

September 7, 2025
This Stanford computer science professor went to written exams 2 years ago because of AI. He says his students insisted on it – Fortune

Stanford Professor Returns to Written Exams After Students Demand It Amid AI Rise

September 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version