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    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

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    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

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    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

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    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

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    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

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Cells from Cadaver Pancreas May Help Treat Type 1 Diabetes

July 1, 2023
in Health
Cells from Cadaver Pancreas May Help Treat Type 1 Diabetes
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June 30, 2023 – Treatment of hard-to-manage type 1 diabetes with transplanted pancreatic cells is moving forward on two fronts, with one product newly approved and the other making headway in a clinical trial. 

Type 1 diabetes is an autoimmune disease where insulin-producing pancreatic beta cells (often called just “islets,” because they reside in the islets of Langerhans part of the pancreas) are destroyed by the body’s own immune reactions. People with the condition take insulin via shots or a pump to stay alive and must also regularly measure their blood sugar levels and adjust their insulin. 

But some people with type 1 diabetes often have severe low blood sugar (hypoglycemia) and may not feel the symptoms, such as shaking and sweatiness, that signal a blood sugar drop. Those people (known as hypoglycemia unaware) are the only candidates for islet cell therapy, in part because they must also take medication to suppress their immune system to prevent rejection – in the same way that it is required for any other transplanted organ, such as a kidney – and that brings risk as well. Researchers are working to end the need for immunosuppressants. 

The FDA on Wednesday approved Lantidra, a therapy made from pancreatic islet cells from dead donors who have, or whose families have, agreed to donate their organs after their death. Lantidra, made by CellTrans, is approved for people with type 1 diabetes who can’t achieve target blood sugar levels using insulin. 

In clinical trials with Lantidra, 21 out of 30 patients did not need to take insulin for at least 1 year, while 10 were still insulin-independent more than 5 years after the treatment. But in five patients, it didn’t work at all. 

Meanwhile, in an early clinical trial of a different type of pancreatic islet cell made from stem cells, Vertex Pharmaceuticals’ VX-880, two people with type 1 diabetes and severe hypoglycemia have been able to completely come off insulin for at least a year, and three others are moving in that direction. Those findings were presented on June 23 at the annual American Diabetes Association’s Scientific Sessions. 

Both types of islets are infused into the portal vein, which carries blood from several organs to the liver, as well as insulin from the pancreas to the liver in people without type 1 diabetes. 

“For decades now, the promise of pancreatic islet transplantation as a treatment for a small subset of those with the most difficult to control type 1 diabetes – and in particular, those with frequent and severe hypoglycemia – has faced two major hurdles,” said David M. Harlan, MD, co-director of the University of Massachusetts Diabetes Center of Excellence.

“One is an insufficient supply of islets to transplant, and two, the sometimes-toxic immunosuppression required to prevent the transplanted islets from immune rejection,” he said. 

The recent results using VX-880 “hold the promise of overcoming both hurdles in that stem cell-derived islets can be grown in the lab, thereby opening the possibility of a virtually endless supply,” said Harlan, who is also a professor of medicine at the University of Massachusetts Chan Medical School in Worcester.

There were no major safety issues in the VX-880 study, which is now being expanded to include more people in several European countries as well as in the United States. 

With Lantidra, side effects included nausea, fatigue, anemia, and belly pain. Most people in the trial had at least one severe adverse reaction, due to either the IV procedure into the portal vein or from the immune-suppressing medications. In some cases, these events required the person to stop using those medications and lose the function of the transplanted cells. 

“These adverse events should be considered when assessing the benefits and risks of Lantidra for each patient,” the FDA said in a statement. 

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : WebMD – https://www.webmd.com/diabetes/news/20230630/cadaver-cells-may-aid-type-1-diabetes?src=RSS_PUBLIC

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Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

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