* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, October 24, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Johnny Depp Set To Finally Make His Big Hollywood Comeback After Amber Heard Controversy – Yahoo

    Johnny Depp Set for a Triumphant Hollywood Comeback Following Amber Heard Controversy

    ‘Chainsaw Man — The Movie: Reze Arc’ Review: Hit Manga Gets an Ultra-Violent, Surprisingly Emotional Big-Screen Adaptation – Yahoo

    Chainsaw Man – The Movie: Reze Arc Review: A Brutal and Unexpectedly Emotional Big-Screen Adaptation

    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New technology for grading and packing dates – FreshPlaza

    Revolutionary Technology Transforms Date Grading and Packing Process

    Project underway to upgrade technology on 911 towers in Kanawha County – WCHS

    Kanawha County Launches Major Upgrade to 911 Tower Technology

    Next steps: Technology opens new options for greater mobility – Missouri Independent

    Next Steps: How Technology is Opening Exciting New Doors to Greater Mobility

    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Johnny Depp Set To Finally Make His Big Hollywood Comeback After Amber Heard Controversy – Yahoo

    Johnny Depp Set for a Triumphant Hollywood Comeback Following Amber Heard Controversy

    ‘Chainsaw Man — The Movie: Reze Arc’ Review: Hit Manga Gets an Ultra-Violent, Surprisingly Emotional Big-Screen Adaptation – Yahoo

    Chainsaw Man – The Movie: Reze Arc Review: A Brutal and Unexpectedly Emotional Big-Screen Adaptation

    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New technology for grading and packing dates – FreshPlaza

    Revolutionary Technology Transforms Date Grading and Packing Process

    Project underway to upgrade technology on 911 towers in Kanawha County – WCHS

    Kanawha County Launches Major Upgrade to 911 Tower Technology

    Next steps: Technology opens new options for greater mobility – Missouri Independent

    Next Steps: How Technology is Opening Exciting New Doors to Greater Mobility

    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Chemoimmunotherapy Improves Pathologic Outcomes in Gastroesophageal Carcinoma

November 25, 2023
in Health
Chemoimmunotherapy Improves Pathologic Outcomes in Gastroesophageal Carcinoma
Share on FacebookShare on Twitter

Adding immunotherapy to neoadjuvant chemotherapy for resectable gastroesophageal cancer led to higher rates of disease downstaging and pathologic complete response (pCR), an exploratory analysis of a randomized trial showed.

Downstaging favored the addition of atezolizumab (Tecentriq) whether defined as no evidence of tumor in the primary lesion (ypT0), residual tumor less than 5 cm (ypT0-2), or no evidence of disease in lymph nodes (ypN0). Histologic complete response, defined as pathologic complete response (pCR) or TRG1a, occurred more often with atezolizumab, and the difference from chemotherapy alone increased particularly in patients with a PD-L1 composite positive score (CPS) ≥10.

Margin-free resection rates and the frequency and severity of adverse events were similar in the two groups, Salah-Eddin Al-Batran, MD, of the Institute of Clinical Research and UTC-University Cancer Center in Frankfurt, Germany, and coauthors reported in the Journal of Clinical Oncology (JCO).

“To our knowledge, this is the first large, randomized trial to report on the safety, histopathologic regression, and surgical-pathologic outcome measures after neoadjuvant chemotherapy combined with an ICI [immune checkpoint inhibitor] for EGA [esophagogastric adenocarcinoma],” the authors stated.

“The current study transitioned to a phase III trial, evaluating whether the favorable pathologic regression and tumor downstaging would translate into survival benefit, and if this effect is dependent on PD-L1 expression,” they continued. “In the future, neoadjuvant chemoimmunotherapy has the potential to become a new treatment option in locally advanced gastroesophageal adenocarcinoma. Nevertheless, the challenge will be to identify who will and will not benefit from the addition of immunotherapy.”

The trial is the first full report of a randomized controlled trial (RCT) of neoadjuvant chemoimmunotherapy in gastric/gastroesophageal junction adenocarcinoma (GEA), and the results are consistent with those of three other RCTs, according to the authors of an accompanying editorial.

“In non-small cell lung cancer and triple-negative breast cancer, improved pathologic response rates after neoadjuvant immunotherapy-containing treatment have translated to improvements in survival,” wrote Mojun Zhu, MD, and Harry H. Yoon, MD, both of the Mayo Clinic in Rochester, Minnesota.

“Together, these promising results raise the possibility that neoadjuvant immunotherapy-containing treatment in GEA might improve survival, thereby helping address the fourth-highest cause of cancer mortality in the world,” they added.

In summarizing the study’s clinical and scientific relevance, JCO deputy editor Andrew H. Ko, MD, of the University of California San Francisco, said the results provide “encouraging early signals of antitumor activity from adding an anti-PD-L1 antibody to perioperative chemotherapy for patients with resectable esophagogastric cancer.”

“However,” said Ko, “whether the improved rates of pathologic response and downstaging translate into a recurrence-free and overall survival benefit remains to be seen from this and other studies evaluating a similar strategy, and so should not yet be adopted into routine clinical practice.”

Multimodality perioperative treatment has consistently improved overall survival (OS) in GEA, Al-Batran and coauthors stated in their introduction. Neoadjuvant therapy increases the likelihood of complete margin-free (R0) resection and induces histopathologic regression, which correlates with improved survival. Perioperative use of fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) has increased the rate of complete regression and major histopathologic regression, which also has translated into improved OS.

Nonetheless, long-term survival remains unsatisfactory, the authors continued. The addition of ICIs to chemotherapy has the potential to enhance chemosensitivity and inhibit immune-independent and dependent tumorigenic processes in GEA. Anti-PD-1/L1 antibodies have been approved for patients with unresectable/metastatic disease, but their activity in the neoadjuvant setting has not been established.

Investigators organized a multicenter, randomized phase II trial to examine the impact of adding atezolizumab to FLOT on progression-free/disease-free survival in resectable GEA. The trial initially had a sample size of 295 patients. Following conversion to a phase III study, the required sample size increased to 556 patients, and the primary endpoint was changed to event-free survival. The primary objective of the phase II portion of the study was changed to be exploratory in nature, with only surgical pathology endpoints.

The exploratory analysis included all 295 patients from phase II, all with confirmed GEA and clinical stage ≥cT2 and/or cN+ and no evidence of distant metastasis. Patients were randomized to receive FLOT with or without atezolizumab. Patients assigned to FLOT alone received four preoperative cycles and four postoperative cycles of therapy. Patients assigned to the atezolizumab arm received the agent in combination with FLOT, followed by eight additional cycles of the checkpoint inhibitor.

Baseline characteristics of the patients included microsatellite instability in 8% and a PD-L1 CPS ≥1 in 58%. Rates of surgical morbidity were 45% in the atezolizumab arm and 42% with FLOT alone, and 60-day mortality was 3% with atezolizumab versus 2% without.

Downstaging favored the addition of atezolizumab, regardless of the definition:

ypT0: 23% vs 15% (P=0.044)ypT0-T2: 61% vs 48% (P=0.015)ypN0: 68% vs 54% (P=0.012)

Complete regression rates (pCR or TRG1a) also were significantly higher with atezolizumab (24% vs 15%, P=0.032). Margin-free complete resection occurred in a similar proportion of patients treated with atezolizumab/FLOT (96%) or FLOT alone (95%).

The incidence and severity of adverse events were similar between treatment groups. Therapy delay occurred in 80-90% of both groups, and dose modification for chemotherapy occurred at least once in 69% of the atezolizumab group and 54% of the FLOT-only arm. Toxicity was the reason cited for 87% of dose modifications. Rates of serious adverse events (AEs) were 69% with atezolizumab and 66% with FLOT alone.

The most common nonsurgical grade 3/4 AEs were neutropenia, leukopenia, diarrhea, nausea, and peripheral sensory neuropathy, each occurring in a similar proportion of patients in the two treatment groups. Premature discontinuation rates for reasons other than progression or death were 48% with atezolizumab and 45% with FLOT only.

author['full_name']

Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. He joined MedPage Today in 2007. Follow

Disclosures

The study was supported by Roche and Hector Stiftung.

Al-Batran disclosed relationships with Bristol Myers Squibb, Merck Sharp & Dohme, AstraZeneca/Daiichi Sankyo, Eli Lilly, AIO gGmbH, MCI Group, Celgene, Sanofi, Roche, Vifor Pharma, Eurozyto, Immutep, and Ipsen.

Yoon disclosed relationships with Merck, LSK BioPharma, BeiGene, Macrogenics, Zymeworks, ALX Oncology, Bristol Myers Squibb, Astellas, OncXerna Therapeutics, Novartis, Amgen, AstraZeneca, Elevation Oncology, Roche/Genentech, Lilly/ImClone, Boston Biomedical, and CARsgen Therapeutics.

Primary Source

Journal of Clinical Oncology

Source Reference: Lorenzen S, et al “Perioperative atezolizumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable esophagogastric cancer: Interim results from the randomized, multicenter, phase II/III DANTE/IKF-s633 trial” J Clin Oncol 2023; DOI: 10.1200/JCO.23.00975.

Secondary Source

Journal of Clinical Oncology

Source Reference: Zhu M, Yoon HH “Neoadjuvant immunotherapy in gastroesophageal cancer: A promising early signal?” J Clin Oncol 2023; DOI: 10.1200/JCO.23.01982.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/othercancers/107515

Tags: ChemoimmunotherapyhealthImproves
Previous Post

Two Approaches for Infected Necrotizing Pancreatitis Go Head-to-Head

Next Post

We Need ICD Codes for Climate-Linked Health Outcomes

Enhancing Nucleic Acid Biosecurity to Counter Advanced Generative Protein Design Tools

October 24, 2025
Science Says Optimistic People Live Up to 12 Years Longer. Here’s How You Can Be More Positive, Hopeful, and Confident – Inc.com

Unlock a Longer Life: Discover How Cultivating Optimism Transforms Your Health and Happiness

October 24, 2025
Fall River Eats: Eskimo King closes for season; Table for Two special at Fall River Grill – Yahoo

Eskimo King Closes for the Season – Enjoy the Irresistible Table for Two Special at Fall River Grill!

October 24, 2025
New technology for grading and packing dates – FreshPlaza

Revolutionary Technology Transforms Date Grading and Packing Process

October 24, 2025
Your weekend plans: Satire, scares and sports – Axios

Get Ready for the Weekend: Satire, Spooks, and Sports Galore!

October 24, 2025
Dodgers’ Alex Vesia’s World Series availability unclear while dealing with ‘deeply personal family matter’ – CBS Sports

Dodgers’ Alex Vesia Faces Uncertainty Over World Series Availability Amid Personal Family Matter

October 24, 2025
Fewer pastors say economy is negatively impacting their churches in 2025: Lifeway Research – Christian Post

Growing Number of Pastors See Positive Economic Impact on Their Churches in 2025

October 24, 2025
Johnny Depp Set To Finally Make His Big Hollywood Comeback After Amber Heard Controversy – Yahoo

Johnny Depp Set for a Triumphant Hollywood Comeback Following Amber Heard Controversy

October 24, 2025
Duke professor Kyle Walsh to lead environmental institute of NIH after atypical selection process – The Duke Chronicle

Duke Professor Kyle Walsh Takes the Helm of NIH Environmental Institute After Unconventional Selection Process

October 24, 2025
‘A growing cancer’: The right’s growing acknowledgment of its own antisemitism – CNN

A Growing Cancer: How the Right Is Facing Its Own Antisemitism

October 24, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (883)
  • Economy (905)
  • Entertainment (21,776)
  • General (17,778)
  • Health (9,946)
  • Lifestyle (918)
  • News (22,149)
  • People (906)
  • Politics (915)
  • Science (16,116)
  • Sports (21,405)
  • Technology (15,885)
  • World (888)

Recent News

Enhancing Nucleic Acid Biosecurity to Counter Advanced Generative Protein Design Tools

October 24, 2025
Science Says Optimistic People Live Up to 12 Years Longer. Here’s How You Can Be More Positive, Hopeful, and Confident – Inc.com

Unlock a Longer Life: Discover How Cultivating Optimism Transforms Your Health and Happiness

October 24, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version