* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, October 17, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Bricktown continues to thrive as OKC’s entertainment district – OKC VeloCity

    Bricktown Shines as Oklahoma City’s Premier Entertainment Hotspot

    This Haunting ‘60s Country Song Is Even More Tragic Than You Remember – Yahoo

    This Haunting ’60s Country Song Will Break Your Heart All Over Again

    Arts/Entertainment: ‘Wait Until Dark’ brings spooky season center stage – Times Herald Online

    Wait Until Dark’ Delivers Chilling Thrills Perfect for the Spooky Season

    Bluesman James Montgomery Will Perform In Falmouth – CapeNews.net

    Blues Legend James Montgomery Ready to Ignite the Stage in Falmouth

    Mexican singer Pedro Fernández to make Ave Fénix tour stop in Stockton. Tickets, schedule – Yahoo

    Mexican Singer Pedro Fernández Brings the Ave Fénix Tour to Stockton – Don’t Miss It!

    Flutter Entertainment’s SWOT Analysis: Uncovering the Growth Potential Amid Challenges

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Spanning the Gulf: Global Defence Technology 155 – Army Technology

    Spanning the Gulf: Exploring Cutting-Edge Global Defence Technology

    A Nobel Prize for explaining when technology leads to growth – NPR

    Nobel Prize Awarded for Unraveling How Technology Drives Economic Growth

    Erie Canal’s 200th anniversary: How a technological marvel for trade changed the environment forever – The Conversation

    Erie Canal’s 200th Anniversary: How a Trade Marvel Transformed the Environment Forever

    Day 5 of Gains Streak for Solidion Technology Stock with 475% Return (vs. -20% YTD) [10/14/2025] – Trefis

    Solidion Technology Stock Rockets for 5th Consecutive Day, Soaring an Astonishing 475% Year-to-Date

    Tracking DNA and RNA Together To Unlock Disease Insights – Technology Networks

    Unlocking Disease Insights by Tracking DNA and RNA Together

    The future of battery technology – Engineer Live

    Revolutionizing Energy: Exploring the Future of Battery Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Bricktown continues to thrive as OKC’s entertainment district – OKC VeloCity

    Bricktown Shines as Oklahoma City’s Premier Entertainment Hotspot

    This Haunting ‘60s Country Song Is Even More Tragic Than You Remember – Yahoo

    This Haunting ’60s Country Song Will Break Your Heart All Over Again

    Arts/Entertainment: ‘Wait Until Dark’ brings spooky season center stage – Times Herald Online

    Wait Until Dark’ Delivers Chilling Thrills Perfect for the Spooky Season

    Bluesman James Montgomery Will Perform In Falmouth – CapeNews.net

    Blues Legend James Montgomery Ready to Ignite the Stage in Falmouth

    Mexican singer Pedro Fernández to make Ave Fénix tour stop in Stockton. Tickets, schedule – Yahoo

    Mexican Singer Pedro Fernández Brings the Ave Fénix Tour to Stockton – Don’t Miss It!

    Flutter Entertainment’s SWOT Analysis: Uncovering the Growth Potential Amid Challenges

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Spanning the Gulf: Global Defence Technology 155 – Army Technology

    Spanning the Gulf: Exploring Cutting-Edge Global Defence Technology

    A Nobel Prize for explaining when technology leads to growth – NPR

    Nobel Prize Awarded for Unraveling How Technology Drives Economic Growth

    Erie Canal’s 200th anniversary: How a technological marvel for trade changed the environment forever – The Conversation

    Erie Canal’s 200th Anniversary: How a Trade Marvel Transformed the Environment Forever

    Day 5 of Gains Streak for Solidion Technology Stock with 475% Return (vs. -20% YTD) [10/14/2025] – Trefis

    Solidion Technology Stock Rockets for 5th Consecutive Day, Soaring an Astonishing 475% Year-to-Date

    Tracking DNA and RNA Together To Unlock Disease Insights – Technology Networks

    Unlocking Disease Insights by Tracking DNA and RNA Together

    The future of battery technology – Engineer Live

    Revolutionizing Energy: Exploring the Future of Battery Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Daily Low-Dose Aspirin Upped Incidence of Anemia in Older Adults

June 20, 2023
in Health
Daily Low-Dose Aspirin Upped Incidence of Anemia in Older Adults
Share on FacebookShare on Twitter

Daily low-dose aspirin increased incident anemia among otherwise healthy older adults, a secondary analysis of the randomized ASPREE trial showed.

Over a median of 4.7 years, the incidence of anemia was 51.2 events per 1,000 person-years in the aspirin group compared with 42.9 events per 1,000 person-years in the placebo group (HR 1.20, 95% CI 1.12-1.29), reported Zoe McQuilten, MBBS, PhD, of Monash University in Melbourne, Australia, and colleagues.

The estimated probability of having anemia within 5 years was 23.5% for those taking aspirin compared with 20.3% for those on placebo, they noted in the Annals of Internal Medicine.

The treatment effect was the same in the sensitivity analysis accounting for cancer incidence (HR 1.20, 95% CI 1.11-1.30), and after adjusting for characteristics associated with increased risk for anemia (adjusted HR 1.19, 95% CI 1.11-1.28).

In addition, hemoglobin levels declined by a mean 3.6 g/L per 5 years in the placebo group, while those in the aspirin group had an estimated lower baseline mean of 0.4 g/L, and experienced a steeper decline in hemoglobin over time by 0.6 g/L per 5 years compared with placebo.

And in over 7,000 participants with ferritin measures at baseline and 3 years, those in the aspirin group had greater prevalence of ferritin levels less than 45 mg/L at year 3 (13% vs 9.8% with placebo) and greater overall decline in ferritin by 11.5% versus placebo.

Of note, 3% of participants in the aspirin group experienced at least one clinically significant bleeding event compared with 2.1% of those in the placebo group.

“We knew from large clinical trials, including our ASPREE trial, that daily low-dose aspirin increased the risk of clinically significant bleeding,” McQuilten told MedPage Today in an email. “From our study we found that low-dose aspirin also increased the risk of developing anemia during the trial and this was most likely due to bleeding that was not clinically apparent.”

“In many people, anemia may have other consequences, such as fatigue and general decline in function and cognition,” she added.

The incidence of anemia is known to increase with age, and it’s estimated that about 17% of adults ages 65 and up are anemic, with a higher prevalence among people in nursing homes and hospitals.

Prior research has shown that anemia in older adults was associated with higher overall mortality, lower quality of life, higher cardiovascular disease (CVD) incidence, greater risk of falls and fractures, and longer hospital stays, while previous results from the ASPREE trial showed associations between use of low-dose aspirin and increases in overall mortality and deaths from cancer in the elderly.

The increased health risks and costs of care tied to anemia in older adults provide “further reasons to restrict the use of low-dose aspirin to those with an evidence-based indication and to monitor for development of iron-deficiency anemia in persons taking regular aspirin,” the authors wrote.

William Hung, MD, MPH, of the Icahn School of Medicine at Mount Sinai in New York City, told MedPage Today that the study’s findings show that occult blood loss and anemia are “potential harms for older adults taking aspirin for primary prevention” in addition to the known risk of major bleeding events.

“The U.S. Preventive Services Task Force already recommends against low-dose aspirin for primary prevention in older adults ages 60 and over,” he noted. “This study adds to the evidence for that recommendation.”

This post-hoc analysis of the ASPREE (Aspirin in Reducing Events in the Elderly) trial randomly assigned 19,114 participants ages 70 and older (or 65 and older for Black and Hispanic adults) in the U.S. and Australia to 100 mg of aspirin or placebo daily. Among all participants, mean age was 74, 56% were women, and 93% were white.

Risks with aspirin were consistent across sex and age, and in those with chronic kidney disease, diabetes, alcohol or tobacco use, prior aspirin use, and continued use of low-dose non-steroidal anti-inflammatory drugs and proton pump inhibitors.

McQuilten and colleagues noted that anemia may have been identified and treated by practitioners outside of the trial between annual reviews, which may have led to an underestimate of anemia incidence.

Disclosures

The trial was supported by grants from the National Institute on Aging, the National Cancer Institute, the National Health and Medical Research Council of Australia (NHMRC), Monash University, the Victorian Cancer Agency, and the Alfred Health Trust. Additional support and funding was provided by Abbott Diagnostics and the Alfred Pathology Service.

McQuilten and co-authors reported relationships with the NHMRC, the NIH, Pfizer, Freenome, Zoe Ltd, the American Cancer Society, the Bill and Melinda Gates Foundation, Vifor Pharma, GiveWell, and ITL BioMedical.

Primary Source

Annals of Internal Medicine

Source Reference: McQuilten ZK, et al “Effect of low-dose aspirin versus placebo on incidence of anemia in the elderly” Ann Intern Med 2023; DOI: 10.7326/M23-0675.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/geriatrics/generalgeriatrics/105070

Tags: DailyhealthLow-Dose
Previous Post

I Never Asked Why the Bodies Kept Coming

Next Post

YouTube Removes RFK Jr. Video; Tick-Borne Virus Spreads; Woman in Ecuador Dies Again

Takeaways from the first general election debate in the NYC mayoral race – CNN

Takeaways from the first general election debate in the NYC mayoral race – CNN

October 17, 2025
Shattered concrete, dirty water and asbestos: Israeli bombing causes ‘unparalleled’ ecological crisis in Gaza – TBIJ

Devastating Israeli Bombing Triggers Unprecedented Ecological Crisis in Gaza

October 17, 2025

Celebrating 15 Years of Family Fun and Discovery at the Wisconsin Science Festival

October 17, 2025
Why are humans religious? Scientists are studying miracles to find out. – National Geographic

Why Do Humans Believe in Miracles? Scientists Explore the Mystery of Religion

October 17, 2025
Man Missing His Dog While at the Club Is Far Too Relatable – Yahoo

Man Missing His Dog While at the Club Is Far Too Relatable – Yahoo

October 17, 2025
Spanning the Gulf: Global Defence Technology 155 – Army Technology

Spanning the Gulf: Exploring Cutting-Edge Global Defence Technology

October 17, 2025
Ohio State vs. Wisconsin prediction, pick, odds, spread, where to watch live – CBS Sports

Ohio State vs. Wisconsin prediction, pick, odds, spread, where to watch live – CBS Sports

October 16, 2025
Equipping agents for the real world with Agent Skills – Anthropic

Unlocking Agent Potential: Mastering Advanced Skills to Tackle Real-World Challenges

October 16, 2025
Comments – The AI boom is propping up the whole economy – Slow Boring

How the AI Boom Is Fueling an Economic Revolution

October 16, 2025
Bricktown continues to thrive as OKC’s entertainment district – OKC VeloCity

Bricktown Shines as Oklahoma City’s Premier Entertainment Hotspot

October 16, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (871)
  • Economy (892)
  • Entertainment (21,764)
  • General (17,638)
  • Health (9,934)
  • Lifestyle (905)
  • News (22,149)
  • People (893)
  • Politics (903)
  • Science (16,103)
  • Sports (21,392)
  • Technology (15,872)
  • World (875)

Recent News

Takeaways from the first general election debate in the NYC mayoral race – CNN

Takeaways from the first general election debate in the NYC mayoral race – CNN

October 17, 2025
Shattered concrete, dirty water and asbestos: Israeli bombing causes ‘unparalleled’ ecological crisis in Gaza – TBIJ

Devastating Israeli Bombing Triggers Unprecedented Ecological Crisis in Gaza

October 17, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version