* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, July 1, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Ostin Technology (OST): Volatility’s Warning or Contrarian Opportunity? – AInvest

    Ostin Technology (OST): Navigating Market Volatility – Red Flag or Hidden Opportunity?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Ostin Technology (OST): Volatility’s Warning or Contrarian Opportunity? – AInvest

    Ostin Technology (OST): Navigating Market Volatility – Red Flag or Hidden Opportunity?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals

October 13, 2023
in Health
Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals
Share on FacebookShare on Twitter

Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals

Increased hippocampal neurogenesis induced by forniceal DBS lasts for at least 3 weeks but not as long as 6 weeks. Credit: Brain Stimulation (2023). DOI: 10.1016/j.brs.2023.09.002

A recent study from the lab of Dr. Jianrong Tang, associate professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital shows that deep brain stimulation (DBS) of a specific brain region results in a significant and sustained improvement of memory in Rett mice. Moreover, they found that this treatment promotes the generation of new healthy neurons in these mice.

The study, published in the journal Brain Stimulation, provides crucial preclinical evidence that supports the development of DBS as a feasible treatment for Rett syndrome patients.

Rett syndrome (RTT) is a rare but devastating neurodevelopmental disorder that causes regression of motor, social, cognitive, and language skills along with the development of autistic behaviors and seizures. It is caused by mutations in the X-linked gene that encodes the methyl-CpG-binding protein 2 (MeCP2) protein and thus, primarily affects young girls. Since the loss of cognitive skills is one of the tragic aspects of this condition, there has been intense interest in developing therapeutic approaches to mitigate this loss.

Forniceal DBS induces significant and sustained improvements in learning and memory among RTT mice

DBS is a neurosurgical procedure that involves the placement of a medical device called a neurostimulator to send electrical signals through the electrodes that have been implanted in targeted brain regions to treat various neurological conditions such as movement disorders (e.g. Parkinson’s, tremors, dystonia), neuropsychiatric disorders (e.g. obsessive-compulsive disorders, depression), and epilepsy.

“Inspired by a study which showed that stimulation of the fornix region of the hippocampus improved memory in Alzheimer’s disease, a few years ago we performed forniceal DBS in a mouse model of RTT and found that two weeks of a specific regimen of this treatment improved learning and memory in female RTT mice,” Dr. Jianrong Tang said.

“While those findings demonstrated the potential of DBS to mitigate learning and memory deficits in RTT, it was not clear how long the benefits of this treatment would last.”

Their goal in this study was to address that question. Using well-established behavioral assays, they discovered that DBS improved contextual fear memory in RTT mice and these beneficial effects persisted for 6 to 9 weeks after the treatment. Further, repeated DBS—specifically in the fornix, not other brain regions—maintained the contextual memory improvement in RTT mice.

Forniceal DBS induces the production of new hippocampal neurons in adult RTT mice

Adult hippocampal neurogenesis—the process of forming new neurons in specialized regions of the hippocampus of adult animals—is critical for the neurons to “learn and remember.”

Previous studies from the Tang lab revealed that right after the DBS treatment, there was a significant formation of new neurons in specialized regions of the hippocampus. Since it takes anywhere between 2-5 weeks for newborn neurons to be mature and functionally integrate into the neural networks, this correlated with improved contextual memory in these mice three weeks later. Here, they found this close correspondence between the DBS-induced birth of new neurons and improvements in contextual memory persisted several weeks after the treatment as well.

Forniceal DBS promotes a neuroprotective environment with healthy neurons

In female mice that carry one copy of defective MECP2, the expression of this gene is switched off/inactivated in some neurons. This means some newborn neurons in RTT mice will be healthy and have MeCP2 while others may not express MeCP2. Interestingly, the Duncan NRI team found that forniceal DBS preferentially induced the birth of more healthy neurons with MeCP2 in Rett mutants.

Moreover, DBS treatment also induced the production of a key neurotrophin -brain-derived neurotrophic factor(BDNF)—which is a neuroprotective molecule essential for the survival and growth of neurons as well as for their plasticity i.e., their ability to learn and remember.

“The findings from this study are very promising. We found forniceal DBS not only results in a significant and long-lasting improvement to memory in Rett animals, but that it also promotes a favorable neuroprotective environment in the brain and leads to the production of more healthy neurons—which together suggests DBS could be an excellent therapy to treat Rett patients,” Dr. Tang said.

More information:
Qi Wang et al, Forniceal deep brain stimulation in a mouse model of Rett syndrome increases neurogenesis and hippocampal memory beyond the treatment period, Brain Stimulation (2023). DOI: 10.1016/j.brs.2023.09.002

Citation:
Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals (2023, October 13)
retrieved 13 October 2023
from https://medicalxpress.com/news/2023-10-deep-brain-healthy-neurons-sustained.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-10-deep-brain-healthy-neurons-sustained.html

Tags: Brainhealthstimulation
Previous Post

Calorie restriction in humans builds strong muscle and stimulates healthy aging genes: Study

Next Post

DOT1L gene variants associated with a new neurological disorder

Groundbreaking technology to help police tackle violence against women – The Independent

Revolutionary Technology Transforms the Fight Against Violence Toward Women

July 1, 2025
Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

July 1, 2025
Nature’s headlamps: A unique light-focusing structure in Parasesarma de Man, 1895 mangrove crabs – ESA Journals

Nature’s headlamps: A unique light-focusing structure in Parasesarma de Man, 1895 mangrove crabs – ESA Journals

July 1, 2025
Scientists found what just might be Earth’s oldest rocks – Boy Genius Report

Scientists found what just might be Earth’s oldest rocks – Boy Genius Report

July 1, 2025
The EU must show leadership and stand up for science, health and women’s rights – The Parliament Magazine

Why the EU Needs to Take the Lead in Protecting Science, Health, and Women’s Rights

July 1, 2025
Anna Rossi Returns to Broadcast Television with Boston 25, Launching New Lifestyle Series Ahead of July 4th Holiday – PR Newswire

Anna Rossi’s Triumphant Return to Broadcast TV: Don’t Miss Her Exciting New Lifestyle Series Launching Just in Time for July 4th!

July 1, 2025
Chelsea win Club World Cup’s most absurd game yet – ESPN

Chelsea Triumphs in the Most Bizarre Club World Cup Match Ever

July 1, 2025
Analysis: China’s Economy and Its Influence on Global Markets – U.S. Bank

How China’s Economy is Shaping the Future of Global Markets

July 1, 2025
WATCH: Republicans Block Sen. Ossoff’s Amendment to Prevent Increases to Georgians’ Health Insurance Premiums – Ossoff.senate.gov

WATCH: Republicans Block Sen. Ossoff’s Bold Move to Prevent Health Insurance Premium Hikes for Georgians

July 1, 2025
Mamdani’s New York victory boosts pro-Palestine politics in US – Al Jazeera

Mamdani’s New York victory boosts pro-Palestine politics in US – Al Jazeera

July 1, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (701)
  • Economy (725)
  • Entertainment (21,614)
  • General (15,650)
  • Health (9,765)
  • Lifestyle (731)
  • News (22,149)
  • People (726)
  • Politics (732)
  • Science (15,943)
  • Sports (21,223)
  • Technology (15,710)
  • World (706)

Recent News

Groundbreaking technology to help police tackle violence against women – The Independent

Revolutionary Technology Transforms the Fight Against Violence Toward Women

July 1, 2025
Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

July 1, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version