* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, July 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Efgartigimod Offers Hope in Chronic Inflammatory Demyelinating Polyneuropathy

November 5, 2023
in Health
Efgartigimod Offers Hope in Chronic Inflammatory Demyelinating Polyneuropathy
Share on FacebookShare on Twitter

PHOENIX — A subcutaneous infusion of efgartigimod cut the risk of relapse in patients with a rare but serious immune-mediated neuropathy, according to the phase II ADHERE trial.

Patients with diagnosed chronic inflammatory demyelinating polyneuropathy (CIDP) treated with efgartigimod alfa and hyaluronidase-qvfc (Vyvgart Hytrulo) saw a 61% reduction in the risk of relapse versus placebo, based on time to the first adjusted Inflammatory Neuropathy Cause and Treatment (INCAT) deterioration of ≥1 point (HR 0.39, P=0.000039), reported Richard Lewis, MD, of Cedars-Sinai Medical Center in Los Angeles.

Patients on the study agent also experienced longer time to relapse versus those on placebo, Lewis and colleagues stated in a poster at the American Association of Neuromuscular & Electrodiagnostic Medicine annual meeting. The rapid separation of the Kaplan-Meier curves began at week 4 and was sustained through week 48.

All ADHERE patients were treated in clinics where they received the 90-second infusion of efgartigimod coformulated with recombinant human hyaluronidase PH20 (rHuPH20) which allows for rapid subcutaneous administration of larger volumes, Lewis said. IV efgartigimod (Vyvgart) was approved by the FDA in 2021 as a treatment for generalized myasthenia gravis (gMG) and the subcutaneous formulation was approved in 2023 for gMG.

Lewis told MedPage Today that ADHERE “did not have an at-home component to it…but I think in the future there may very well be a way that patients can self-administer PH20.”

Arindra Jayasekara, MD, of Riverside Community Hospital/University of California Riverside, told MedPage Today said the ADHERE results will broaden the treatment field for people with this rare and serious autoimmune disease of the peripheral nervous system. “Right now, these patients have limited options such as IV immunoglobulin or plasma exchange…I think that eventually the subcutaneous infusion will be something that can be done at home.”

But Jayasekara, who was not involved in the study, cautioned that “patients have to be educated about the risks and benefits. It will be helpful for those individuals who may not have the wherewithal to go to an infusion center. Subcutaneous infusion would be a better choice for these people or others who have problems with IV infusions.”

ADHERE had two stages: Stage A enrolled 322 patients with CIDP who underwent treatment. Responders in stage A were entered into Stage B, where the primary endpoint was the relative risk of relapse based on time to relapse on the INCAT Disability Score, which ranges from 0-10 for arm and leg disabilities.

Patients in both stages were about age 54 and over a third were female. The average time since diagnosis with CIDP was around 4 years. The adjusted INCAT scores for those in stage A, stage B, and placebo were 4.6, 3.1, and 3.3, respectively. Grip strength scores in the dominant hand were 38.5 kPa, 54.9 kPa, and 58 kPa, respectively. More than 60% had unstable, active CIDP.

In stage A, patients on the study agent demonstrated a clinically meaningful mean improvement of 7.7 points on the Inflammatory Rasch-built Overall Disability Scale (I-RODS) of upper and lower limb disability, along with a 12.3 kPa improvement in grip strength. This clinically meaningful benefit was maintained in stage B by patients on the study agent but was lost in those on placebo.

In stage B, those on the study drug had a lower relapse rate versus placebo at week 24 (26% vs 54%) and week 48 (34% vs 60%).

The most frequent treatment-related adverse event (TRAE) was injection site reactions (20% of stage A patients; 10% of stage B patients), but all cases were mild to moderate and resolved over time. Lewis stated that about 5% of patients in both groups reported a serious AE, but none were TRAEs. There were two deaths in stage A (n=1 COVID-19; n=1 worsening CIDP). There was a single pneumonia-related death of a placebo patient in stage B.

Disclosures

The trial was funded by argenx.

Lewis disclosed relationships with CSL Behring, Grifols, Pfizer, Sanofi, argenx, Roche, Johnson & Johnson, Takeda, Boehringer Ingelheim, and Momenta.

Jayasekara disclosed no relationships with industry.

Primary Source

American Association of Neuromuscular & Electrodiagnostic Medicine

Source Reference: Lewis R, et al “Efficacy, safety and tolerability of subcutaneous efgartigimod PH20 in patients with chronic inflammatory demyelinating polyneuropathy: Results from the ADHERE trial” AANEM 2023.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/aanem/107166

Tags: Efgartigimodhealthoffers
Previous Post

Patient count in cyclospora outbreak tops 2,200

Next Post

ERA and SGLT2 Inhibitor Combo Cuts Albuminuria in Chronic Kidney Disease

Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

July 6, 2025
Ben Shelton’s sister booed by Wimbledon crowd when job revealed – Yahoo Sports

Wimbledon Crowd Booes Ben Shelton’s Sister Following Shocking Job Reveal

July 6, 2025
New book digs into Indigenous cuisine through archaeology, culture, ecology – Gander Newsroom

Unveiling Indigenous Cuisine: Exploring the Rich Tapestry of Archaeology, Culture, and Ecology

July 6, 2025
BANG! James Webb telescope catches stray galaxies in the Bullet Cluster: Space photo of the week – Live Science

BANG! James Webb Telescope Unveils Breathtaking Image of Stray Galaxies in the Bullet Cluster

July 6, 2025
How Do You Teach Computer Science in the A.I. Era? – The New York Times

Unlocking Success: Mastering Computer Science Education in the Age of A.I

July 6, 2025
If you want to be younger looking in 60 days, start practicing these 8 daily habits – VegOut

If you want to be younger looking in 60 days, start practicing these 8 daily habits – VegOut

July 6, 2025
Real Madrid vs Borussia Dortmund 3-2: FIFA Club World Cup – as it happened – Al Jazeera

Real Madrid vs Borussia Dortmund 3-2: FIFA Club World Cup – as it happened – Al Jazeera

July 6, 2025

Israel’s economy can’t survive a long war with Iran – and Trump knows it – Middle East Eye

July 6, 2025
The long-term health risks as extreme heat becomes a new normal – PBS

Uncovering the Silent, Long-Term Health Risks of Life in Extreme Heat

July 6, 2025
Trump Says He Will Start Talks With China on TikTok Deal – The New York Times

Trump Says He Will Start Talks With China on TikTok Deal – The New York Times

July 6, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (707)
  • Economy (732)
  • Entertainment (21,621)
  • General (15,741)
  • Health (9,770)
  • Lifestyle (737)
  • News (22,149)
  • People (733)
  • Politics (741)
  • Science (15,949)
  • Sports (21,232)
  • Technology (15,717)
  • World (713)

Recent News

Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

July 6, 2025
Ben Shelton’s sister booed by Wimbledon crowd when job revealed – Yahoo Sports

Wimbledon Crowd Booes Ben Shelton’s Sister Following Shocking Job Reveal

July 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version