* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, July 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Emicizumab Can Delay Immunosuppressive Tx in Acquired Hemophilia A

October 19, 2023
in Health
Emicizumab Can Delay Immunosuppressive Tx in Acquired Hemophilia A
Share on FacebookShare on Twitter

Early emicizumab (Hemlibra) prophylaxis alone prevented clinically relevant bleeds in patients with newly diagnosed acquired hemophilia A, while avoiding the infectious complications of immunosuppressive therapy in this vulnerable population, a phase II study showed.

Over 12 weeks of therapy, a high-dose regimen of the factor VIIIa mimetic antibody yielded a low mean breakthrough bleeding rate (0.04 bleeds per patient-week, upper 97.5% CI 0.06), meeting predefined criteria for success, reported Andreas Tiede, MD, PhD, of the Hannover Medical School in Germany, and colleagues in Lancet Haematology.

In fact, 70% of the 47 patients in the single-arm study had no breakthrough bleeds through 12 weeks, and investigators observed few thromboembolic events, severe infections, and fatalities.

“The consistently low bleeding rates over 12 weeks of prophylaxis confirm the prophylactic activity of emicizumab,” wrote Tiede and colleagues. “In addition, they also open the perspective that immunosuppression can be safely postponed in severely ill patients with acquired hemophilia A until they [have] recovered from the initial illness and reached a sufficiently stable health status to take the risks of immunosuppression.”

Acquired hemophilia A is a severe bleeding disorder caused by autoantibodies, or inhibitors, that interfere with the activity of factor VIII. Often occurring unexpectedly, the rare disorder can affect individuals of any age, though often turns up in the elderly.

Treatment involves immediate control of acute bleeding with hemostatic medication and long-term elimination of inhibitors through immunosuppressive therapy — which is associated with toxicity, infectious complications, and mortality in this frail population of patients, explained Tiede and colleagues.

In a commentary accompanying the study, Margaret V. Ragni, MD, MPH, of the University of Pittsburgh Medical Center and Hemophilia Center of Western Pennsylvania, said the strategy employed in the trial “will probably be practice-changing, and adopted into standard care, as it is safe and effective and improves the risk–benefit ratio.”

Furthermore, noted Ragni, “none of the group developed thrombotic microangiopathy or drug-related thrombosis, and more importantly, by avoiding immunosuppression for 12 weeks, some patients had natural reduction in inhibitor titers, such that future immunosuppression was averted.”

And, she pointed out, none of the four deaths during the study were due to infection.

The phase II study was conducted at 16 hemophilia centers in Germany and Austria. The median age of the study population was 76 years. Patients were eligible if they were diagnosed with acquired hemophilia A on the basis of a factor VIII activity of less than 50 IU/dL and a positive factor VIII inhibitor, were bleeding at the time of screening, and had not received immunosuppressive therapy.

Patients received and completed an accelerated high-dose emicizumab loading regimen in the first week (6 mg/kg and 3 mg/kg on days 1 and 2) in order to protect them from bleeds in the early weeks following diagnosis, with emicizumab maintenance dosing (1.5 mg/kg) continued after that until week 12.

Of the 47 patients enrolled, 33 had no bleeding events through 12 weeks, while seven patients (15%) had one bleed, six patients (13%) had two bleeds, and one patient (2%) had three bleeds.

The study was conducted during the pandemic (2021 to 2022), and the most frequently reported adverse events (AEs) reported during the 24-week study period were COVID-related (10 patients). AEs of grade 3 or worse included COVID in two patients, two cases of acute kidney injury, and one stroke.

Starting at week 12 or later, 29 of the patients began receiving immunosuppressive therapy; none had AEs related to immunosuppression, and 14 experienced remission.

Four patients died on study (two from bleeding, one from COVID, and one from cardiac arrest). None of the deaths were considered related to emicizumab.

Authors noted that randomization of emicizumab prophylaxis was not considered ethical due to the severity of the patients’ illness and the increasing off-label use of the therapy in hemophilia A.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

The study was supported by Hoffman-La Roche.

Tiede reported relationships (including institutional ties) with Bayer, BioMarin, Biotest, Chugai, CSL Behring, Novo Nordisk, Octapharma, Pfizer, Roche, Sobi, and Takeda. Co-authors reported multiple relationships with industry.

Ragni disclosed relationships (including institutional ties) with BioMarin, Biotest, Chugai, Hemab Therapeutics, Sanofi, Spark, and Takeda Pharmaceuticals.

Primary Source

The Lancet Haematology

Source Reference: Tiede A, et al “Emicizumab prophylaxis in patients with acquired haemophilia A (GTH-AHA-EMI): an open-label, single-arm, multicentre, phase 2 study” Lancet Haematol 2023; DOI: 10.1016/S2352-3026(23)00280-6.

Secondary Source

The Lancet Haematology

Source Reference: Ragni MV “Rapidly loading emicizumab without immunosuppression in acquired haemophilia” Lancet Haematol 2023; DOI: 10.1016/S2352-3026(23)00303-4.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/hemophilia/106888

Tags: delayEmicizumabhealth
Previous Post

Senators Grill NIH Director Nominee on Drug Prices, Gender-Affirming Care

Next Post

Strange upward lightning shoots out X-rays as it rises to the clouds

Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

July 2, 2025
NBA’s Malik Beasley sued for $2.25M by sports agency for breach of contract, alleged unpaid loan amid federal gambling probe – Yahoo Sports

NBA’s Malik Beasley sued for $2.25M by sports agency for breach of contract, alleged unpaid loan amid federal gambling probe – Yahoo Sports

July 2, 2025
He’s searching for a human-made problem in areas largely untouched by humans. Answers are just emerging – CNN

He’s searching for a human-made problem in areas largely untouched by humans. Answers are just emerging – CNN

July 1, 2025
Asteroid 2024 YR4 might smash into the moon – Popular Science

Urgent Alert: Asteroid 2024 YR4 Headed Straight for the Moon!

July 1, 2025
These 9 towns were named the ‘quirkiest’ in New Jersey, according to World Atlas – Bergen Record

These 9 towns were named the ‘quirkiest’ in New Jersey, according to World Atlas – Bergen Record

July 1, 2025
Trump’s Tax Bill Won’t Help or Hurt the Economy. The Deficit Is Already Huge. – Barron’s

Trump’s Tax Bill Won’t Help or Hurt the Economy. The Deficit Is Already Huge. – Barron’s

July 1, 2025
Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

July 1, 2025
Who would be affected by health care cuts in Senate version of Trump’s budget bill – PBS

Who Will Be Hit Hardest by Health Care Cuts in the Senate’s Trump Budget Plan?

July 1, 2025
Senate passes Trump’s reconciliation bill with Vance casting tie-breaking vote – PBS

Senate Passes Trump’s Reconciliation Bill After Vance Casts Decisive Tie-Breaking Vote

July 1, 2025
Groundbreaking technology to help police tackle violence against women – The Independent

Revolutionary Technology Transforms the Fight Against Violence Toward Women

July 1, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (701)
  • Economy (726)
  • Entertainment (21,615)
  • General (15,659)
  • Health (9,766)
  • Lifestyle (731)
  • News (22,149)
  • People (727)
  • Politics (733)
  • Science (15,944)
  • Sports (21,224)
  • Technology (15,711)
  • World (707)

Recent News

Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

July 2, 2025
NBA’s Malik Beasley sued for $2.25M by sports agency for breach of contract, alleged unpaid loan amid federal gambling probe – Yahoo Sports

NBA’s Malik Beasley sued for $2.25M by sports agency for breach of contract, alleged unpaid loan amid federal gambling probe – Yahoo Sports

July 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version