* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Epigenetic Markers May Predict Kidney Failure Risk in T1D

May 23, 2024
in Health
Epigenetic Markers May Predict Kidney Failure Risk in T1D
Share on FacebookShare on Twitter

TOPLINE:

A DNA methylation signature outperformed a clinical model at identifying individuals with type 1 diabetes (T1D) who risked progressing to end-stage kidney disease.

METHODOLOGY:

Researchers measured DNA methylation (DNAmet) in blood cells from 277 individuals with T1D and diabetic kidney disease (DKD) and followed them from 7 to 20 years to identify variations in DNAmet linked to the risk for kidney failure (KF).They conducted an epigenetic analysis of the identified 5′-cytosine-phosphate-guanine-3′ loci (CpGs) that were associated with KF, independent of clinical risk factors.They then developed a prediction model for KF risk to compare with a clinical model. 

TAKEAWAY:

51% of the cohort developed KF during follow-up. The team’s epigenome-wide analysis identified DNAmet at 17 CpGs that were associated with risk for KF, independent of major clinical risk factors; the DNAmet at these KF-associated CpGs remained stable over a median period of 4.7 years and were previously validated in an independent cohort. DNAmet variations at seven of the KF-associated CpGs were strongly associated with multiple genetic variants at seven genomic regions, suggesting that there is a strong genetic influence on DNAmet. The effects of DNAmet variations at the KF-associated CpGs on risk for KF were partially mediated by multiple KF-associated circulating proteins and KF-associated circulating miRNAs.The new model significantly improved prediction performance (c-statistic=0.93) compared with the clinical model (c-statistic=0.85).

IN PRACTICE:

“We…identified DNAmet variation at certain KF-associated CpGs that can improve the risk prediction of KF, thereby providing potential much needed noninvasive biomarkers,” the researchers wrote. “Our findings can have important translational implications for early detection and prevention of KF in patients with T1D DKD.”

SOURCE:

The study was led by Zhuo Chen, City of Hope, Duarte, California and published online on May 22, 2024, in Science Translational Medicine.

LIMITATIONS:

The study findings are limited by the relatively small sample size and a need for more mechanistic work.

DISCLOSURES:

The study was supported in part by multiple grants from the US National Institutes of Health (NIH); Wanek family project for the Cure of T1D at City of Hope; Novo Nordisk Foundation (NNF); Helmsley Charitable Trust grant; and a Juvenile Diabetes Research Foundation grant. The FinnDiane study (validation cohort) was supported by grants from Folkhälsan Research Foundation, Wilhelm and Else Stockmann Foundation, “Liv och Hälsa” Society, Sigrid Juselius Foundation, Helsinki University Central Hospital Research Funds, NNF, Academy of Finland, and the NIH.

Only the principal investigator disclosed competing interests, mostly as an advisory board member for various pharmaceutical companies and for Medscape Medical News.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/epigenetic-markers-may-predict-kidney-failure-risk-t1d-2024a10009ng

Tags: epigenetichealthmarkers
Previous Post

Tumor mutations may not predict response to immunotherapy, study finds

Next Post

IV Thrombolysis Offers No Benefit for Mild Stroke

Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

October 22, 2025
November Family Consumer Science Program – Alachua County

November Family Consumer Science Program – Alachua County

October 22, 2025
Correction: Anti-Science Movement story – The News-Gazette

Unraveling the Truth Behind the Anti-Science Movement: A Closer Look

October 22, 2025
Best Burgers 2025: 9 cult-favorite burgers off the beaten path – Yahoo

Best Burgers 2025: 9 cult-favorite burgers off the beaten path – Yahoo

October 22, 2025
Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

Rydberg Technologies Launches Exciting New Photonics Division in Berlin

October 22, 2025
Forbes Unveils First-Ever “Most Powerful Women In Sports” List, Featuring 25 Of The Trailblazers Transforming The Industry, Including Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams And More – Forbes

Meet the 25 Trailblazing Women Revolutionizing the World of Sports, Featuring Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams and More

October 22, 2025
Grandmaster Daniel Naroditsky remembered for his impact on the chess world – NPR

Grandmaster Daniel Naroditsky: Honoring a Timeless Chess Legacy

October 22, 2025
Seattle’s Creative Economy: Building Talent, Culture, and Community – GeekWire

Seattle’s Creative Economy: How Talent, Culture, and Community Are Shaping the Future

October 22, 2025
Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

October 22, 2025
Self-efficacy mediates the effect of hope on health promotion intention in Chinese stroke patients – Nature

How Hope Boosts Health Motivation in Chinese Stroke Patients Through Self-Efficacy

October 22, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (881)
  • Economy (902)
  • Entertainment (21,773)
  • General (17,746)
  • Health (9,943)
  • Lifestyle (915)
  • News (22,149)
  • People (903)
  • Politics (912)
  • Science (16,113)
  • Sports (21,402)
  • Technology (15,882)
  • World (885)

Recent News

Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

October 22, 2025
November Family Consumer Science Program – Alachua County

November Family Consumer Science Program – Alachua County

October 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version