* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, August 5, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘Billie Jean’ – Hyde Park Herald

    The Enduring Magic Behind ‘Billie Jean’ Revealed

    Hank Hill returns to a changed world in new ‘King of the Hill’ episodes – New Haven Register

    Hank Hill Navigates a Bold New World in Thrilling New ‘King of the Hill’ Episodes

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Nasdaq-listed Verb Technology to build $558 million TON treasury, rebrand as TON Strategy Co. – The Block

    Nasdaq-Listed Verb Technology to Build $558 Million TON Treasury and Rebrand as TON Strategy Co

    How Tech Firms Like Google and Meta Are Embracing the Military – The New York Times

    How Tech Firms Like Google and Meta Are Embracing the Military – The New York Times

    Credo Technology: Wiring The AI Revolution (NASDAQ:CRDO) – Seeking Alpha

    Credo Technology: Driving the Next Wave of AI Innovation

    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘Billie Jean’ – Hyde Park Herald

    The Enduring Magic Behind ‘Billie Jean’ Revealed

    Hank Hill returns to a changed world in new ‘King of the Hill’ episodes – New Haven Register

    Hank Hill Navigates a Bold New World in Thrilling New ‘King of the Hill’ Episodes

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Nasdaq-listed Verb Technology to build $558 million TON treasury, rebrand as TON Strategy Co. – The Block

    Nasdaq-Listed Verb Technology to Build $558 Million TON Treasury and Rebrand as TON Strategy Co

    How Tech Firms Like Google and Meta Are Embracing the Military – The New York Times

    How Tech Firms Like Google and Meta Are Embracing the Military – The New York Times

    Credo Technology: Wiring The AI Revolution (NASDAQ:CRDO) – Seeking Alpha

    Credo Technology: Driving the Next Wave of AI Innovation

    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

ERS Roundup: Cell Transplant Boosts Lung Function in COPD Patients

September 16, 2023
in Health
ERS Roundup: Cell Transplant Boosts Lung Function in COPD Patients
Share on FacebookShare on Twitter

MILAN — Research presented at this year’s annual European Respiratory Society congress included early successes in transplanting a patient’s own lung cells to ease chronic obstructive pulmonary disease (COPD), idrevloride treatment for primary ciliary dyskinesia, and using ultrasounds as a guide for more comprehensive pulmonary embolism screening.

Improved Gas Exchange Capacity in COPD Through Lung Cell Transplants

Autologous P63+ lung progenitor cell transplantation could help improve lung function for COPD patients, a phase I trial suggested.

After cell transplants, median diffusing capacity of the lungs for carbon monoxide increased from 30% to 39.7% after 12 weeks, then up to 40.3% after 24 weeks. Two patients who were previously experiencing mild emphysema also saw resolved symptoms after 24 weeks, which was confirmed though CT. Emphysema patients with more severe symptoms saw mild improvements.

“The intrapulmonary administration of cells is feasible and safe, and points to significant improvements in lung diffusion capacity after cell therapy,” said Wei Zuo, PhD, of Tongji University in Shanghai. “Mild emphysema, which was previously considered permanent, can be repaired by cell transplantation.”

Zuo explained that in this process, currently existing P63+ progenitor cells were extracted from COPD patients via bronchoscopic brush, cloned, then transplanted back into the donor patient through bronchoscopic injection. Patients received close medical monitoring for 24 weeks. Single doses of cloned progenitor cells consisted of approximately 0.6~5.2×106 cells for every kg of the patient’s body weight.

The first-in-human study included 20 COPD patients, with three patients acting as a control group.

No grade ≥3 adverse events occurred in patients, while 47.1% of transplant patients and 33.3% of control patients experienced grade 1 events. Grade 2 adverse events were seen in 5.9% of treatment patients and 33.3% of control patients.

The average patient St. George’s Respiratory Questionnaire scores improved in 58.8% of the transplant group and 33.3% of the control group. Median 6-minute walk test results improved in two-thirds of treatment patients, while patients in the control group only saw maintenance or decreases in their scores. Forced expiratory volume in the first second (FEV1) improved in 23.5% of treatment patients, while control patients saw no improvement.

A phase II trial of the transplantation treatment is currently approved for COPD, as is a phase I/II trial in idiopathic pulmonary fibrosis.

Idrevloride for Primary Ciliary Dyskinesia

Inhaling idrevloride for about 4 weeks led to significant improvements of lung function in primary ciliary dyskinesia (PCD) when compared to just hypertonic saline alone, the CLEAN-PCD study found.

After 28 days using idrevloride in hypotensive saline, percent predicted FEV1 (ppFEV1) improved 1.5% more than with hypotensive saline solution alone (P=0.044). This was also true when treatment was extended for 56 days. Findings from the phase II study were also recently published in Lancet Respiratory Medicine.

Presenter Thomas Ferkol, Jr., MD, of the University of North Carolina at Chapel Hill, said the idrevloride therapy will be studied as part of an upcoming year-long phase III study in PCD.

PCD is a rare genetic disorder, estimated to impact one person per 7,500 worldwide. Patients with PCD experience impairments of motile ciliary function, which can present itself in a wide array of symptoms ranging from chronic respiratory tract disease to subfertility.

Ferkol noted that studies on the disorder are far and few between, with only two previously published randomized controlled trials on the subject.

“Over 50 genes have been linked with primary ciliary dyskinesia, and at current, there is no specific therapy for this disease. In fact, most of the therapies we use have been borrowed from other diseases like cystic fibrosis and asthma,” he added.

Ultrasound as Gatekeeper to Imaging for Pulmonary Embolism

Utilizing ultrasounds could drastically cut down on the number of referrals to diagnostic imaging for pulmonary embolism (PE), but more work is needed to reduce false negatives.

In the ultrasound group of a randomized trial, PE was considered confirmed in patients who exhibited visible proximal deep venous or ventricular thrombus, two or more subpleural infarctions, and/or McConnell’s sign or D-sign. PE was dismissed if patients didn’t appear to have those signs, had an obvious differential diagnosis thanks to the ultrasound, and if PE was not considered a likely diagnosis.

Patients were only sent on for further imaging when they met neither set of criteria, resulting in referrals to such diagnostic imaging falling by 45.2% with the ultrasound strategy. PE was diagnosed in 20 out of 40 people who underwent diagnostic imaging in this group, with another three diagnosed through discovery of deep venous thrombosis.

However, ultrasound carried a 6.7% failure rate, as two out of 30 people turned out to have PE after having it dismissed initially, reported Casper Falster, MD, a PhD candidate at the Odense Respiratory Research Unit in Denmark, who stressed the possibility of failure with ultrasound as a detection method.

“It is very important to consider that if I wanted to reduce referral by half, I could just flip a coin,” he said.

Falster stated that while D-dimer is an existing test that can help diagnose PE, it gets less specific with patient age and comorbidity.

author['full_name']

Elizabeth Short is a staff writer for MedPage Today. She often covers pulmonology and allergy & immunology. Follow

Disclosures

The COPD study was sponsored by Regend Therapeutics, and Zuo reported a relationship with the study funder.

CLEAN-PCD was supported by the NIH, the Cystic Fibrosis Foundation, ReCode Therapeutics, and Parion Sciences/Vertex Pharmaceuticals, which funded the study. Ferkol reported relationships with the Cystic Fibrosis Foundation, Translate Bio, and Arrowhead Pharmaceuticals.

Falster reported relationships with AstraZeneca and Bristol Meyers Squibb.

Primary Source

European Respiratory Society

Source Reference: Wang Y, et al “Autologous transplantation of P63+ lung progenitor cells for chronic obstructive pulmonary disease therapy” ERS 2023.

Secondary Source

European Respiratory Society

Source Reference: Falster C, et al “Does ultrasound in suspected pulmonary embolism safely reduce referral to diagnostic imaging? – a randomized controlled trial” ERS 2023.

Additional Source

European Respiratory Society

Source Reference: Ringshausen F, et al “Safety and efficacy of idrevloride in people with primary ciliary dyskinesia: a double-blind, randomized, placebo-controlled crossover trial (CLEAN-PCD)” ERS 2023.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/ers/106373

Tags: healthRoundupTransplant
Previous Post

FDA Reviewers Have Concerns About Artificial Womb Trials in Humans

Next Post

Medical Debt Is Killing Our Patients

Your nature photo might be a scientific breakthrough in disguise – ScienceDaily

Could Your Nature Photo Unlock the Next Big Scientific Breakthrough?

August 5, 2025
Scientists reexamine 47-year-old fossil and discover a new Jurassic sea monster – ScienceDaily

47-Year-Old Fossil Reveals an Astonishing New Jurassic Sea Monster

August 5, 2025
Moment of Science: Parker probe offers insights into sun, solar wind – WIS News 10

Parker Probe Unveils New Secrets About the Sun and Solar Wind

August 5, 2025
Nurse, marathon runner Jin Lee promotes healthy lifestyle by example – Bucks County Herald newspaper

Nurse, marathon runner Jin Lee promotes healthy lifestyle by example – Bucks County Herald newspaper

August 5, 2025
Who’s the top dog? Wave-riding canines compete in the World Dog Surfing Championships – NPR

Meet the Ultimate Wave-Riding Dogs Competing for the World Surfing Championship!

August 5, 2025
‘The Big Short’ investor warns despite economy’s stronghold against ‘thoughtless,’ ‘unprecedented’ tariffs so far, stagflation is coming – Fortune

The Big Short’ Investor Issues Stark Warning: Stagflation Threatens Despite Economy’s Surprising Strength Against Unprecedented Tariffs

August 5, 2025
‘Billie Jean’ – Hyde Park Herald

The Enduring Magic Behind ‘Billie Jean’ Revealed

August 5, 2025
Health insurance in Pennsylvania may see biggest hike in years – 90.5 WESA

Pennsylvania Braces for Its Largest Health Insurance Increase in Years

August 5, 2025
The Origins of the Political Power Grab in Texas – The New York Times

Inside Texas’s Bold Quest for Political Control

August 5, 2025
Nasdaq-listed Verb Technology to build $558 million TON treasury, rebrand as TON Strategy Co. – The Block

Nasdaq-Listed Verb Technology to Build $558 Million TON Treasury and Rebrand as TON Strategy Co

August 5, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (755)
  • Economy (780)
  • Entertainment (21,657)
  • General (16,295)
  • Health (9,817)
  • Lifestyle (788)
  • News (22,149)
  • People (779)
  • Politics (789)
  • Science (15,993)
  • Sports (21,275)
  • Technology (15,757)
  • World (761)

Recent News

Your nature photo might be a scientific breakthrough in disguise – ScienceDaily

Could Your Nature Photo Unlock the Next Big Scientific Breakthrough?

August 5, 2025
Scientists reexamine 47-year-old fossil and discover a new Jurassic sea monster – ScienceDaily

47-Year-Old Fossil Reveals an Astonishing New Jurassic Sea Monster

August 5, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version