* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Extended-Infusion Antibiotics Tied to Reduced Mortality From Bloodstream Infections

July 5, 2024
in Health
Extended-Infusion Antibiotics Tied to Reduced Mortality From Bloodstream Infections
Share on FacebookShare on Twitter

Extended infusion of beta-lactam therapy was associated with reduced mortality in patients with severe gram-negative bloodstream infections, according to a retrospective cohort study.

At 90 days, 22% of patients receiving extended-infusion beta-lactam therapy had died compared with 28% of patients who received intermittent infusions (adjusted OR 0.71, 95% CI 0.52-0.97), reported Pranita Tamma, MD, MHS, of Johns Hopkins University School of Medicine in Baltimore, and colleagues.

However, this survival benefit was limited to patients with severe illness or those with bacterial isolates with elevated minimum inhibitory concentrations, they noted in JAMA Network Open.

For patients with a Pitt bacteremia score of at least 4 points, 38.7% who received extended-infusion therapy had died at 90 days versus 55.6% of those who received intermittent infusions (aOR 0.47, 95% CI 0.28-0.81, P=0.006). Meanwhile, 7.1% of patients with elevated beta-lactam minimum inhibitory concentrations in the extended-infusion group died compared with 23.8% of those in the intermittent-infusion group (aOR 0.06, 95% CI 0.01-0.66, P=0.02).

When researchers excluded these two subgroups in a stratified analysis, extended infusions did not offer any survival benefit.

“Taken together with the increase in adverse events we observed, this study helps define populations [in whom] this strategy has ‘the most bang for its buck,'” co-author Sara Karaba, MD, PhD, MHS, also of Johns Hopkins, told MedPage Today in an email.

As Karaba noted, there were increased odds of catheter complications in the extended-infusion group (aOR 3.14, 95% CI 1.66-5.96), as well as increased odds of antibiotic discontinuation because of adverse events, such as acute kidney injury, cytopenias, and seizures (aOR 3.66, 95% CI 1.68-7.95).

“The potential benefits of extended-infusion beta-lactam therapy need to be balanced against the increased risk of complications that may be associated with this infusion strategy,” the study authors cautioned.

They also observed that emergence of resistance was similar in the extended-infusion therapy group (2.9%) versus the intermittent-infusion therapy group (7.2%), but the difference was not statistically significant (P=0.35).

“Whether infusion strategy — i.e., extended infusion — may reduce the development of subsequent resistance warrants additional investigation,” Karaba noted.

Clinical trials assessing outcomes with prolonged intravenous administration of beta-lactams have shown conflicting results. For example, a randomized trial showed that prolonged administration of the beta-lactam meropenem in sepsis or septic shock conferred no survival benefit compared with intermittent infusions. Another recent study and a meta-analysis showed that prolonged infusion for sepsis or septic shock tended to improve mortality compared with conventional intermittent infusion.

In an accompanying editorial, Miranda So, PharmD, MPH, of the University of Toronto, noted that “this study supports prior knowledge about extended infusion of beta-lactam, which has been taught in clinical education and implemented in many centers in recent years. By improving how beta-lactams are administered, extended infusion can overcome isolates with a higher MIC.”

“The study also supports that extended infusion may have an advantage over intermittent infusion in patients with more severe infections,” she wrote. “In turn, reliance on non-beta-lactam antibiotics, which are often second- or third-line therapy, may be reduced.”

Of note, the study population included patients with severe immune compromise, such as those with bone marrow or solid organ transplant and those with neutropenia, “all of whom are in great need of effective antimicrobials,” So pointed out.

This retrospective cohort study included 4,861 adults (median age 67, 52.4% men) with gram-negative bloodstream infections who were hospitalized in the U.S. from January through December 2019. Of these patients, 1,408 were included in a 1:3 nearest-neighbor propensity score matching without replacement: 352 were in the extended-infusion group and 1,056 were in the intermittent-infusion group.

Patients in the extended-infusion group received intravenous antibiotics for at least 72 hours, while the intermittent-infusion group received intravenous antibiotics over 1 hour or less. Antibiotics included piperacillin-tazobactam, aztreonam, ceftazidime, cefepime, and meropenem, among others.

One limitation to the study was that it used data from 2019 and the use of extended-infusion beta-lactam therapy may not reflect current practices, Tamma and colleagues said.

author['full_name']

Katherine Kahn is a staff writer at MedPage Today, covering the infectious diseases beat. She has been a medical writer for over 15 years.

Disclosures

The study was funded by a grant from the FDA to Tamma.

Karaba reported personal fees from Entasis. Other co-authors reported personal fees from Debiopharm, the Duke Clinical Research Institute, and Wolters Kluwer (Lexi-Comp).

So reported no conflicts of interest.

Primary Source

JAMA Network Open

Source Reference: Karaba SM, et al “Extended-infusion β-lactam therapy, mortality, and subsequent antibiotic resistance among hospitalized adults with gram-negative bloodstream infections” JAMA Netw Open 2024; DOI: 10.1001/jamanetworkopen.2024.18234.

Secondary Source

JAMA Network Open

Source Reference: So M “Optimizing the value of β-lactam antibiotics through extended infusion” JAMA Netw Open 2024; DOI: 10.1001/jamanetworkopen.2024.18196.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/110956

Tags: antibioticsExtended-Infusionhealth
Previous Post

Plastic Surgery Practice Accused of Posting Fake Reviews Must Pay $5 Million

Next Post

‘Good Luck, Babe’ CPR; Presidential Debate Health Memes; Got Patients on the Mind?

Historic achievement: Governor Ferguson, Ecology celebrate nuclear waste officially being turned into glass at Hanford Site | Governor Bob Ferguson – Governor Ferguson (.gov)

Historic Breakthrough: Governor Ferguson and Ecology Celebrate Nuclear Waste Transformed into Glass at Hanford Site

October 22, 2025
Transcript: Mission to Mars — Bad science fiction – Financial Times

Mission to Mars: When Science Fiction Takes a Dark Turn

October 22, 2025
Science Hill, South Greene volleyball win TSSAA state tournament openers – WCYB

Science Hill and South Greene Dominate Opening Matches in TSSAA State Volleyball Tournament

October 22, 2025
GCC Influencer Market Jumps 75% As Lifestyle Creators Lead Growth – Net Influencer

GCC Influencer Market Soars 75% Fueled by Lifestyle Creators Leading the Boom

October 22, 2025
A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

October 22, 2025
Sports Extra: Fall Week 9 – KEYC News Now

Unforgettable Fall Week 9: Top Must-See Sports Moments

October 22, 2025
Jacobson earns program’s first medal at U23 World Championships – nmuwildcats.com

Jacobson Breaks New Ground with Program’s First Medal at U23 World Championships

October 22, 2025
AHLA: Hotels generate $7B for Denver economy – Hotel Management

Hotels Drive Denver’s Economy to Soar by $7 Billion

October 22, 2025
AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

AMC Launches First New Dolby Experience in Gwinnett Since 2017

October 22, 2025
UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

October 22, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (880)
  • Economy (901)
  • Entertainment (21,772)
  • General (17,735)
  • Health (9,942)
  • Lifestyle (914)
  • News (22,149)
  • People (902)
  • Politics (911)
  • Science (16,112)
  • Sports (21,401)
  • Technology (15,881)
  • World (884)

Recent News

Historic achievement: Governor Ferguson, Ecology celebrate nuclear waste officially being turned into glass at Hanford Site | Governor Bob Ferguson – Governor Ferguson (.gov)

Historic Breakthrough: Governor Ferguson and Ecology Celebrate Nuclear Waste Transformed into Glass at Hanford Site

October 22, 2025
Transcript: Mission to Mars — Bad science fiction – Financial Times

Mission to Mars: When Science Fiction Takes a Dark Turn

October 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version