* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, October 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Extended-Infusion Antibiotics Tied to Reduced Mortality From Bloodstream Infections

July 5, 2024
in Health
Extended-Infusion Antibiotics Tied to Reduced Mortality From Bloodstream Infections
Share on FacebookShare on Twitter

Extended infusion of beta-lactam therapy was associated with reduced mortality in patients with severe gram-negative bloodstream infections, according to a retrospective cohort study.

At 90 days, 22% of patients receiving extended-infusion beta-lactam therapy had died compared with 28% of patients who received intermittent infusions (adjusted OR 0.71, 95% CI 0.52-0.97), reported Pranita Tamma, MD, MHS, of Johns Hopkins University School of Medicine in Baltimore, and colleagues.

However, this survival benefit was limited to patients with severe illness or those with bacterial isolates with elevated minimum inhibitory concentrations, they noted in JAMA Network Open.

For patients with a Pitt bacteremia score of at least 4 points, 38.7% who received extended-infusion therapy had died at 90 days versus 55.6% of those who received intermittent infusions (aOR 0.47, 95% CI 0.28-0.81, P=0.006). Meanwhile, 7.1% of patients with elevated beta-lactam minimum inhibitory concentrations in the extended-infusion group died compared with 23.8% of those in the intermittent-infusion group (aOR 0.06, 95% CI 0.01-0.66, P=0.02).

When researchers excluded these two subgroups in a stratified analysis, extended infusions did not offer any survival benefit.

“Taken together with the increase in adverse events we observed, this study helps define populations [in whom] this strategy has ‘the most bang for its buck,'” co-author Sara Karaba, MD, PhD, MHS, also of Johns Hopkins, told MedPage Today in an email.

As Karaba noted, there were increased odds of catheter complications in the extended-infusion group (aOR 3.14, 95% CI 1.66-5.96), as well as increased odds of antibiotic discontinuation because of adverse events, such as acute kidney injury, cytopenias, and seizures (aOR 3.66, 95% CI 1.68-7.95).

“The potential benefits of extended-infusion beta-lactam therapy need to be balanced against the increased risk of complications that may be associated with this infusion strategy,” the study authors cautioned.

They also observed that emergence of resistance was similar in the extended-infusion therapy group (2.9%) versus the intermittent-infusion therapy group (7.2%), but the difference was not statistically significant (P=0.35).

“Whether infusion strategy — i.e., extended infusion — may reduce the development of subsequent resistance warrants additional investigation,” Karaba noted.

Clinical trials assessing outcomes with prolonged intravenous administration of beta-lactams have shown conflicting results. For example, a randomized trial showed that prolonged administration of the beta-lactam meropenem in sepsis or septic shock conferred no survival benefit compared with intermittent infusions. Another recent study and a meta-analysis showed that prolonged infusion for sepsis or septic shock tended to improve mortality compared with conventional intermittent infusion.

In an accompanying editorial, Miranda So, PharmD, MPH, of the University of Toronto, noted that “this study supports prior knowledge about extended infusion of beta-lactam, which has been taught in clinical education and implemented in many centers in recent years. By improving how beta-lactams are administered, extended infusion can overcome isolates with a higher MIC.”

“The study also supports that extended infusion may have an advantage over intermittent infusion in patients with more severe infections,” she wrote. “In turn, reliance on non-beta-lactam antibiotics, which are often second- or third-line therapy, may be reduced.”

Of note, the study population included patients with severe immune compromise, such as those with bone marrow or solid organ transplant and those with neutropenia, “all of whom are in great need of effective antimicrobials,” So pointed out.

This retrospective cohort study included 4,861 adults (median age 67, 52.4% men) with gram-negative bloodstream infections who were hospitalized in the U.S. from January through December 2019. Of these patients, 1,408 were included in a 1:3 nearest-neighbor propensity score matching without replacement: 352 were in the extended-infusion group and 1,056 were in the intermittent-infusion group.

Patients in the extended-infusion group received intravenous antibiotics for at least 72 hours, while the intermittent-infusion group received intravenous antibiotics over 1 hour or less. Antibiotics included piperacillin-tazobactam, aztreonam, ceftazidime, cefepime, and meropenem, among others.

One limitation to the study was that it used data from 2019 and the use of extended-infusion beta-lactam therapy may not reflect current practices, Tamma and colleagues said.

author['full_name']

Katherine Kahn is a staff writer at MedPage Today, covering the infectious diseases beat. She has been a medical writer for over 15 years.

Disclosures

The study was funded by a grant from the FDA to Tamma.

Karaba reported personal fees from Entasis. Other co-authors reported personal fees from Debiopharm, the Duke Clinical Research Institute, and Wolters Kluwer (Lexi-Comp).

So reported no conflicts of interest.

Primary Source

JAMA Network Open

Source Reference: Karaba SM, et al “Extended-infusion β-lactam therapy, mortality, and subsequent antibiotic resistance among hospitalized adults with gram-negative bloodstream infections” JAMA Netw Open 2024; DOI: 10.1001/jamanetworkopen.2024.18234.

Secondary Source

JAMA Network Open

Source Reference: So M “Optimizing the value of β-lactam antibiotics through extended infusion” JAMA Netw Open 2024; DOI: 10.1001/jamanetworkopen.2024.18196.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/110956

Tags: antibioticsExtended-Infusionhealth
Previous Post

Plastic Surgery Practice Accused of Posting Fake Reviews Must Pay $5 Million

Next Post

‘Good Luck, Babe’ CPR; Presidential Debate Health Memes; Got Patients on the Mind?

Pre-rolls, education and industry optimism: Takeaways from Ohio Cannabis Health & Business Summit 2025 – Cleveland.com

Pre-rolls, Education, and Industry Optimism: Key Takeaways from the Ohio Cannabis Health & Business Summit 2025

October 6, 2025
‘Rage’ politics the latest hurdle for GOP to clear; how prior battles made conservatives stronger: Dave Brat – Fox News

How ‘Rage’ Politics Is Transforming the GOP and Fueling Conservative Determination

October 6, 2025
EarthTalk – Why do eco-advocates consider backyard gardens so crucial to conservation? – Kiowa County Press

How Backyard Gardens Are Becoming the Heart of Conservation Efforts

October 5, 2025
Citizen science discovers a rare bird in town | Opinion – Times Record News

Citizen science discovers a rare bird in town | Opinion – Times Record News

October 5, 2025
Millions could be living with hidden smell loss after COVID without knowing – ScienceDaily

Millions Could Be Unknowingly Struggling with Hidden Smell Loss Following COVID

October 5, 2025
How This Influencer Lost 31 Kg By Following These 8 “Weird” Daily Habits – NDTV

How This Influencer Lost 31 Kg By Following These 8 “Weird” Daily Habits – NDTV

October 5, 2025
Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

October 5, 2025
Tampa Bay Buccaneers vs. Seattle Seahawks NFL game: How to watch, kickoff time, TV channel and more – Yahoo Sports

Tampa Bay Buccaneers vs. Seattle Seahawks: How to Watch, Kickoff Time, TV Channel, and More

October 5, 2025
Magdeleine Vallieres shows off her world championship stripes – EF Pro Cycling

Magdeleine Vallieres shows off her world championship stripes – EF Pro Cycling

October 5, 2025
Splurging? In This Economy? Here’s How to Do It Right. – The New York Times

Splurging? In This Economy? Here’s How to Do It Right. – The New York Times

October 5, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (853)
  • Economy (873)
  • Entertainment (21,747)
  • General (17,432)
  • Health (9,916)
  • Lifestyle (886)
  • News (22,149)
  • People (875)
  • Politics (885)
  • Science (16,084)
  • Sports (21,374)
  • Technology (15,855)
  • World (856)

Recent News

Pre-rolls, education and industry optimism: Takeaways from Ohio Cannabis Health & Business Summit 2025 – Cleveland.com

Pre-rolls, Education, and Industry Optimism: Key Takeaways from the Ohio Cannabis Health & Business Summit 2025

October 6, 2025
‘Rage’ politics the latest hurdle for GOP to clear; how prior battles made conservatives stronger: Dave Brat – Fox News

How ‘Rage’ Politics Is Transforming the GOP and Fueling Conservative Determination

October 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version