* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 8, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Growth factors linked to stem cell aging in bone marrow study

June 23, 2024
in Health
Growth factors linked to stem cell aging in bone marrow study
Share on FacebookShare on Twitter

How old is your bone marrow?

The immunofluorescence image details the morphology and cell composition of a femur from a middle-aged mouse. Credit: The Jackson Laboratory

Our bone marrow—the fatty, jelly-like substance inside our bones—is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells that generate all of the various types of blood cells in our bodies and regenerating themselves to keep the entire assembly line of blood production operating smoothly.

As with any complex system, hematopoietic stem cells lose functionality as they age—and, in the process, contribute to the risk of serious diseases, including blood cancers. We know that the risk of developing aging-associated diseases is different among different individuals. Surprisingly, however, little is known about whether hematopoietic stem cells age differently between individuals.

“If you take a room full of 50-year-olds, some will be completely gray-haired, others will be salt-and-pepper, and a few will not have any gray hairs at all,” said Jennifer Trowbridge, Dattels Family Endowed Chair and professor at the Jackson Laboratory. “Logically, you’d expect to see the same kind of variation in the function of hematopoietic stem cells—but until now, nobody has studied that directly.”

For good reason: because these hematopoietic stem cells are so rare, researchers typically pool all of these stem cells together, studying them in aggregate. In a paper published in Blood, Trowbridge and colleagues studied hematopoietic stem cells at the single cell level in nine individual, genetically identical middle-aged mice—offering the first close look at how subtle changes in the bone marrow microenvironment ages hematopoietic stem cells across individual mice.

Trowbridge and team found that despite the mice being all the same age, the hematopoietic stem cells in the bone marrow of these individual mice aged differently. But that’s not all. The team could predict the function of the hematopoietic stem cells based on the activity of two growth factors that are also present in humans.

The two growth factors—Kitl and Igf1—are produced by mesenchymal stromal cells (MSC) that surround the stem cells in the bone marrow microenvironment. By profiling the RNA transcriptome in these MSCs across individual mice, Trowbridge found that the decline of these growth factors correlated with age-associated molecular programs in hematopoietic stem cells.

“The amount of the growth factors that are being produced directly correlates to the declining function of the stem cells—and we found markedly more variation in hematopoietic stem cells than in other cells in the bone marrow,” Trowbridge said. “This is really a snapshot of the aging process at work, at the cellular level.”

In humans, who are genetically diverse and have varying lifestyles, variations in hematopoietic stem cell aging are likely to be even greater than in carefully controlled animal models, explained Trowbridge. While the current study didn’t explore whether cellular aging of stem cells directly triggers adverse health outcomes, it’s likely that such variations play a role in a wide range of health outcomes for both mice and humans.

More information:
Kira A. Young et al, Variation in Mesenchymal KITL/SCF and IGF1 Expression at Middle Age Underlies Steady-State Hematopoietic Stem Cell Aging, Blood Journal (2024). DOI: 10.1182/blood.2024024275

Journal information:
Blood

Citation:
Growth factors linked to stem cell aging in bone marrow study (2024, June 22)
retrieved 23 June 2024
from https://medicalxpress.com/news/2024-06-growth-factors-linked-stem-cell.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-06-growth-factors-linked-stem-cell.html

Tags: factorsgrowthhealth
Previous Post

Racial, Gender Inequities in CGRP, Gepant Prescriptions

Next Post

Progress in biomarkers related to biliary atresia

Welcome Home: World Aquatics Breaks Ground on Future Headquarters in Budapest – World Aquatics

Welcome Home: World Aquatics Launches Exciting New Headquarters in Budapest

October 8, 2025
New Zealand Surprises With Larger Rate Cut as Economic Concerns Mount – Bloomberg.com

New Zealand Surprises Markets with Larger-Than-Expected Rate Cut Amid Rising Economic Concerns

October 8, 2025
Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

Offset Poised to Finalize Divorce from Cardi B for a Major Reason

October 8, 2025
Health Rounds: Genetics play a role in higher depression risk for women – Reuters

How Genetics Shape Depression Risk in Women: What Everyone Should Understand

October 8, 2025
October 7, 2025 – Federal government shutdown – CNN

October 7, 2025 – Federal government shutdown – CNN

October 8, 2025
Blackwater photos suggest new symbiosis between fish and anemones – EurekAlert!

Breathtaking Blackwater Photos Unveil an Unexpected Alliance Between Fish and Anemones

October 8, 2025
WATCH LIVE: The winner of the Nobel Prize in chemistry is… – PBS

Breaking News: Unveiling the Latest Nobel Prize Winner in Chemistry!

October 8, 2025
Soar through a 1,000-mile-long maze on Mars in this mesmerizing new satellite video – Live Science

Discover a Breathtaking 1,000-Mile-Long Maze on Mars in This Mesmerizing New Satellite Video

October 8, 2025
Video: Dog Sighs in Different Situations Like ‘He Works 9-5′ – Yahoo

Watch This Dog’s Hilarious Sighs That Perfectly Capture Everyday Life Moments

October 8, 2025
US and investors gambling on unproven nuclear technology, warn experts – Financial Times

US and investors gambling on unproven nuclear technology, warn experts – Financial Times

October 8, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (857)
  • Economy (878)
  • Entertainment (21,751)
  • General (17,479)
  • Health (9,920)
  • Lifestyle (890)
  • News (22,149)
  • People (879)
  • Politics (889)
  • Science (16,088)
  • Sports (21,378)
  • Technology (15,858)
  • World (861)

Recent News

Welcome Home: World Aquatics Breaks Ground on Future Headquarters in Budapest – World Aquatics

Welcome Home: World Aquatics Launches Exciting New Headquarters in Budapest

October 8, 2025
New Zealand Surprises With Larger Rate Cut as Economic Concerns Mount – Bloomberg.com

New Zealand Surprises Markets with Larger-Than-Expected Rate Cut Amid Rising Economic Concerns

October 8, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version