* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Hedgehog Pathway Inhibitor Improves IPF

May 21, 2024
in Health
Hedgehog Pathway Inhibitor Improves IPF
Share on FacebookShare on Twitter

SAN DIEGO — Patients with idiopathic pulmonary fibrosis (IPF) had significant improvements in lung function and reversal of lung fibrosis measures after 12 weeks of therapy with an investigational inhibitor of the Hedgehog signaling pathway.

Early efficacy data from a phase 2a safety trial suggest that the novel oral agent dubbed ENV-101 is associated with improvements in forced vital capacity (FVC) and other measures of lung function and may be a disease-modifying therapy for IPF, according to Toby M. Maher, MD, PhD, director of Interstitial Lung Disease in the Keck School of Medicine at the University of Southern California in Los Angeles.

“Historically we’ve not been seeing improvements in FVC, which is what we’ve been seeing [with ENV-101], and I think it’s conceivable that you can get remodeling of early areas of fibrosis in the lung,” Maher said in an interview.

“We know from histology studies that if you look at IPF lungs you’ll see areas of end-stage fibrosis, but even in advanced disease, you’ll see areas where the lung is relatively well preserved and there’s early fibrosis, so I think it’s conceivable that there is remodeling of some of those early areas of fibrosis,” he said.

Vital Pathway

The Hedgehog pathway is highly conserved in evolution. The cell-signaling pathway is active in embryogenesis, tissue proliferation, and organ development. There is also evidence to suggest that in adults, the pathway becomes reactivated after tissue injury, which can occur in lung epithelia, Maher explained.

Although as the word idiopathic in IPF indicates, the etiology of the disease is unknown; investigators have found that in IPF, repetitive epithelial injury to lung tissue leads to activation of the Hedgehog pathway. Hedgehog signaling, in turn, induces formation and activation of myofibroblasts that lay down fibrotic matrix and contract lung tissue, leading to significant impairments in gas exchange, Maher said.

ENV-101 blocks Hedgehog from binding to the PTCH1 receptor, thus preventing release of the zinc-finger protein GLI1 from the kinase complex into the cell cytoplasm. With signaling blocked, myofibroblasts undergo apoptosis instead of initiating wound repair as they normally would, thereby eliminating an evident mechanism of IPF pathology, he explained.

Study Details

In the phase 2a trial, investigators enrolled patients with IPF who were not taking antifibrotic agents and who had a percent-predicted FVC of greater than 50%, percent-predicted diffusing capacity for carbon monoxide of at least 35%, and life expectancy of more than 1 year.

The patients were randomly assigned to receive 200-mg oral ENV-101 daily (18 patients) or placebo (15 patients) for 12 weeks.

The primary endpoint of the trial was safety of the experimental agent. (A previous phase 1b study of a different Hedgehog inhibitor, vismodegib [Erivedge], in combination with the antifibrotic agent pirfenidone [Pirespa] in patients with IPF was discontinued due to poor tolerability.)

In the current study, the most common treatment-related adverse events were dysgeusia in 57% of patients who received the drug, alopecia in 52%, and muscle spasms in 43%. The spasms were generally less severe than were those seen in the vismodegib-pirfenidone trial mentioned above.

Seven patients (33%) had treatment-emergent events leading to dose interruption. Five patients discontinued treatment, including one who withdrew due to taste alterations, one who was lost to follow-up after an IPF exacerbation, and three who withdrew consent.

There were no treatment-related deaths and no clinically significant findings on labs, vital signs, electrocardiograms, or physical examination.

Efficacy Endpoints

An analysis of the secondary efficacy endpoints showed a 1.9% mean improvement in FVC from baseline among patients assigned to ENV-101 compared with a mean decline of 1.3% among patients assigned to placebo (P =.035).

Patients on the active drug also had 200-mL mean increase in total lung capacity compared with a mean decline of 56 mL for patients on placebo (P =.005). 

In addition, high-resolution CT studies also showed a 9.4% absolute decrease from baseline in quantitative interstitial lung disease with ENV-101 vs a 1.1% increase with placebo, a 2% absolute decline from baseline in quantitative lung fibrosis compared with a 0.87% increase with placebo, and a 4.6% absolute decrease from baseline in quantitative ground glass compared with an increase of 0.29% with placebo. 

Bad Taste a Good Sign?

Reinoud Gosens PhD, University of Groningen, the Netherlands, who co-moderated the session but was not involved in the study, questioned whether the dysgeusia seen in patients who received ENV-101 might be related to the dysgeusia seen in clinical trials of P2X3 receptor antagonists for cough. 

“I was wondering if there would be a mechanistic overlap between Hedgehog inhibition and cough, which would be quite relevant for IPF,” he said in an interview.

The increase in FVC seen with ENV-101 and with the investigational agent buloxibutid, a novel angiotensin II type 2 receptor agonist described in a separate presentation by Maher, suggests that these drugs may have the ability to help remodel damaged lungs, Gosens said.

Investigators are currently planning a phase 2 dose-ranging trial (WHISTLE-PF) in patients with IPF or progressive pulmonary fibrosis.

The phase 2a trial was supported by Endeavor BioMedicines. Maher disclosed consultancy or speaker fees from Endeaveor and others. Grosen had no relevant disclosures.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/hedgehog-pathway-inhibitor-improves-lung-function-fibrosis-2024a10009iw

Tags: healthhedgehogpathway
Previous Post

Social mobility extends years lived without dementia, Japanese study reveals

Next Post

Mirikizumab Shows Promise for Moderate to Severe Crohn’s

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Much Worse Than Local Studies Show

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Launches $50M Autism Data Science Initiative to Uncover Causes and Improve Lives

September 23, 2025
Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

September 23, 2025
10 money lessons Boomers learned young that still shape their life choices – VegOut

10 Powerful Money Lessons Boomers Learned Early That Still Shape Their Lives Today

September 23, 2025
Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

September 23, 2025
Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

September 23, 2025
U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

September 23, 2025
AI Tool Predicts Health Problems in Patients 20 Years Before They Emerge – eWeek

AI Tool Detects Health Issues Two Decades Before Symptoms Appear

September 23, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (833)
  • Economy (853)
  • Entertainment (21,731)
  • General (17,200)
  • Health (9,896)
  • Lifestyle (866)
  • News (22,149)
  • People (856)
  • Politics (863)
  • Science (16,064)
  • Sports (21,353)
  • Technology (15,836)
  • World (837)

Recent News

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Much Worse Than Local Studies Show

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Launches $50M Autism Data Science Initiative to Uncover Causes and Improve Lives

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version