* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, June 27, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    North Star Sports & Entertainment Network: Coming soon – KTTC News

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Wayve Expands Engineering Leadership to Power Next-Gen Autonomous Driving Technology – Silicon Canals

    Wayve Boosts Engineering Leadership to Accelerate Next-Gen Autonomous Driving Innovation

    Frontdoor Announces Tech Expert Dr. Bala Ganesh as Chief Technology Officer – Business Wire

    Frontdoor Appoints Tech Visionary Dr. Bala Ganesh as New Chief Technology Officer

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    China’s Military Introduces Mosquito-Sized Drones: A Game-Changing Surveillance Technology – Indian Defence Review

    China Unveils Mosquito-Sized Drones: Revolutionizing Surveillance Technology

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Promising Technology Stocks To Follow Today – June 22nd – MarketBeat

    Top Technology Stocks to Watch Today – June 22nd

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    North Star Sports & Entertainment Network: Coming soon – KTTC News

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Wayve Expands Engineering Leadership to Power Next-Gen Autonomous Driving Technology – Silicon Canals

    Wayve Boosts Engineering Leadership to Accelerate Next-Gen Autonomous Driving Innovation

    Frontdoor Announces Tech Expert Dr. Bala Ganesh as Chief Technology Officer – Business Wire

    Frontdoor Appoints Tech Visionary Dr. Bala Ganesh as New Chief Technology Officer

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    China’s Military Introduces Mosquito-Sized Drones: A Game-Changing Surveillance Technology – Indian Defence Review

    China Unveils Mosquito-Sized Drones: Revolutionizing Surveillance Technology

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Promising Technology Stocks To Follow Today – June 22nd – MarketBeat

    Top Technology Stocks to Watch Today – June 22nd

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Immune cell transformation can influence stem cell transplant success in cancer patients

July 25, 2024
in Health
Immune cell transformation can influence stem cell transplant success in cancer patients
Share on FacebookShare on Twitter

Immune cell transformation can influence stem cell transplant success in cancer patients

Ex vivo expanded murine ILC2s exhibit the phenotypic and functional properties of ILC2s. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50263-7

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have determined that a specific type of immune cell—type II innate lymphoid cells (ILC2s)—can change its characteristics and functions after a cancer patient receives stem cells from a donor, thereby preventing an effective, healthy rebuilding of the immune system. This new understanding of ILC2 cells’ transformational flexibility could lead to better strategies for enhancing immune system recovery post-transplantation.

The finding appeared July 17, 2024, in Nature Communications.

In the U.S., there have been more than 8,000 allogeneic stem cell transplants performed annually over the past decade or so. This procedure, in which healthy cells from a donor are infused into a patient, is frequently used to treat cancers like acute lymphoblastic and acute myelogenous leukemias, a pre-cancer called myelodysplastic syndrome, and some lymphomas.

“Allogeneic transplants can be very effective, and potentially lifesaving, but not all immune cells given to a recipient are reproduced from donor cells,” said Jonathan Serody, MD, corresponding author and Elizabeth Thomas Professor of Medicine, Microbiology and Immunology, chief of hematology at UNC School of Medicine and director of the UNC Cellular Therapy Program.

“Innate type 2 lymphoid cells are often poorly generated once transplanted in a recipient, and the ILC2s that appear to deviate from their innate programming are the cells that cause more problems after a transplant, which is why we chose them as our focus.”

The success of an allogeneic stem cell transplant depends on a variety of factors. The most important are a patient’s remission status, their age and how closely the patient’s and the donor’s human leukocyte antigens (HLAs) match. HLAs are proteins found on most cells. The closer the HLA match, the more likely the procedure will be a success and the less likely the patient will experience a post-transplant complication called graft-versus-host disease where donor immune cells attack recipient’s tissues.

Serody added that knowing the impact of ILC2s on the success of a transplant, and how to potentially influence that impact, also could make an important difference in how to treat a patient.

The majority of experiments the researchers performed were in mice but were also confirmed by other tests on specimens from 12 cancer patients at the Duke Cancer Institute, Durham, North Carolina. In the mouse studies, more than 80% of ILC2 cells donated to mice as part of the transplant transformed to an ILC1-type after 20 days. This unexpected transformation can potentially worsen graft-versus-host disease.

The mouse studies helped the researchers identify, at the level of a single cell, the genetic makeup of each cell as well as how proteins and DNA interacted with each other in the nucleus of the cell. These factors can affect how genes are expressed, which in turn can affect transplant outcomes.

“Our approach revealed the identity of cells in a complex transplant mix, and this knowledge could help us develop novel therapeutic strategies,” said UNC Lineberger’s Ian Davis, MD, Ph.D., study author, chief of pediatric hematology-oncology and Stuart H. Gold Professor of Childhood Cancer at UNC School of Medicine.

“We envision future therapies that, post-transplant, might direct a recovering immune system toward groups of immune cells associated with a favorable outcome.”

The scientists are embarking on a clinical study to test whether the infusion of ILC2 cells can treat lower gastrointestinal graft-versus-host disease. If they find this is a safe approach, they may genetically alter ILC2 cells to make them more effective in a follow-up study.

Serody noted that the level of collaboration between research on graft-versus-host disease in his lab and the work done in Davis’ lab on modulators of gene transcription in cancer is very different from how research is conducted at many other institutions. “This kind of collaboration has allowed this important research finding to efficiently reach its fruition,” Serody said.

The paper’s first authors are Sonia J. Laurie, Ph.D., a postdoctoral fellow at UNC and a member of the Serody lab at UNC Lineberger, and Joseph P. Foster II, a graduate student at UNC and a member of the Davis lab at UNC Lineberger.

More information:
Sonia J. Laurie et al, Type II innate lymphoid cell plasticity contributes to impaired reconstitution after allogeneic hematopoietic stem cell transplantation, Nature Communications (2024). DOI: 10.1038/s41467-024-50263-7

Citation:
Immune cell transformation can influence stem cell transplant success in cancer patients (2024, July 25)
retrieved 25 July 2024
from https://medicalxpress.com/news/2024-07-immune-cell-stem-transplant-success.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-07-immune-cell-stem-transplant-success.html

Tags: healthImmunetransformation
Previous Post

Cancer drug could ease cognitive function for some with autism

Next Post

How stress might be the root of problems like pain, ulcers and a broken heart

Wayve Expands Engineering Leadership to Power Next-Gen Autonomous Driving Technology – Silicon Canals

Wayve Boosts Engineering Leadership to Accelerate Next-Gen Autonomous Driving Innovation

June 26, 2025
Fantasy Football: Which teams are set to pass the most (and least) in 2025? – Yahoo Sports

Fantasy Football Preview: Which Teams Will Lead the League in Passing Attempts in 2025?

June 26, 2025
Tiny night lizards survived dinosaur-killing asteroid strike, despite being close enough to see it happen – Live Science

How Tiny Night Lizards Defied Extinction After the Dinosaur-Killing Asteroid Impact

June 26, 2025
Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals – ScienceAlert

Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals – ScienceAlert

June 26, 2025
Tokyo Lifestyle Makes Strategic Move into Australian Market with Premium Store in Sydney Chinatown – Stock Titan

Tokyo Lifestyle Makes Strategic Move into Australian Market with Premium Store in Sydney Chinatown – Stock Titan

June 26, 2025
First images from world’s largest digital camera reveal galaxies and cosmic collisions – NBC News

First images from world’s largest digital camera reveal galaxies and cosmic collisions – NBC News

June 26, 2025
Spirit Airlines Rebrands Travel Options: First, Premium Economy, Value – One Mile at a Time

Spirit Airlines Unveils Exciting New Travel Options: First, Premium Economy, and Value Classes

June 26, 2025
Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

June 26, 2025

Vanderburgh County Health Department Takes Bold Action Against Vaccine Hesitancy

June 26, 2025
Why Trump needs the world to believe Iran’s nuclear program is ‘obliterated’ – CNN

Why Trump Wants the World to Believe Iran’s Nuclear Program Is Completely Destroyed

June 26, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (698)
  • Economy (718)
  • Entertainment (21,613)
  • General (15,576)
  • Health (9,757)
  • Lifestyle (723)
  • News (22,149)
  • People (720)
  • Politics (725)
  • Science (15,936)
  • Sports (21,215)
  • Technology (15,703)
  • World (698)

Recent News

Wayve Expands Engineering Leadership to Power Next-Gen Autonomous Driving Technology – Silicon Canals

Wayve Boosts Engineering Leadership to Accelerate Next-Gen Autonomous Driving Innovation

June 26, 2025
Fantasy Football: Which teams are set to pass the most (and least) in 2025? – Yahoo Sports

Fantasy Football Preview: Which Teams Will Lead the League in Passing Attempts in 2025?

June 26, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version