* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, August 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    What Are Our Predictions for Taylor Swift’s ‘Life of a Showgirl’ Based on What She’s Told Us So Far? – yahoo.com

    Uncover the Hidden Surprises in Taylor Swift’s ‘Life of a Showgirl’ – Can You Decode Her Clues?

    Bama Dining Serving Up New Food, Entertainment – UA News Center

    Bama Dining Launches Thrilling New Food and Entertainment Experiences

    The latest on Williams-Brice Stadium renovations, entertainment district – On3

    Discover the Thrilling New Upgrades Coming to Williams-Brice Stadium and Its Vibrant Entertainment District!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Alcorn State awarded grant to boost STEM with VR technology – WJTV

    Alcorn State Secures Grant to Transform STEM Education Through Cutting-Edge VR Technology

    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Denver man receives pacemaker using new technology – CBS News

    Denver Man’s Life Transformed by Revolutionary Pacemaker Technology

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    YSU to celebrate launch of new radiology technology program – WKBN.com

    YSU Launches Exciting New Radiology Technology Program Celebration

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    What Are Our Predictions for Taylor Swift’s ‘Life of a Showgirl’ Based on What She’s Told Us So Far? – yahoo.com

    Uncover the Hidden Surprises in Taylor Swift’s ‘Life of a Showgirl’ – Can You Decode Her Clues?

    Bama Dining Serving Up New Food, Entertainment – UA News Center

    Bama Dining Launches Thrilling New Food and Entertainment Experiences

    The latest on Williams-Brice Stadium renovations, entertainment district – On3

    Discover the Thrilling New Upgrades Coming to Williams-Brice Stadium and Its Vibrant Entertainment District!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Alcorn State awarded grant to boost STEM with VR technology – WJTV

    Alcorn State Secures Grant to Transform STEM Education Through Cutting-Edge VR Technology

    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Denver man receives pacemaker using new technology – CBS News

    Denver Man’s Life Transformed by Revolutionary Pacemaker Technology

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    YSU to celebrate launch of new radiology technology program – WKBN.com

    YSU Launches Exciting New Radiology Technology Program Celebration

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Investigating links between tacrolimus dosage and intestinal microbiota to combat organ transplant rejection

July 6, 2023
in Health
Investigating links between tacrolimus dosage and intestinal microbiota to combat organ transplant rejection
Share on FacebookShare on Twitter

transplant surgery

Credit: Pixabay/CC0 Public Domain

Every year in Belgium, 1,600 people wait for a transplant. Of these, in 2021, only 939 received an organ. Thus more than 40% of patients often have to wait more than a year before hoping to receive a transplant.

When a transplant is possible, it is essential to ensure its success so as not to “waste” an organ. One of the keys to successful transplants is an anti-rejection drug, tacrolimus, which patients must take for life. But it is extremely difficult to dose this drug correctly, which can lead to significant risks of transplant failure in the event of underdosing and significant side effects in the event of overdosing (diabetes, hirsutism, hair loss, neuropathy or nephrotoxic effects).

Profs Laure Bindels and Laure Elens of the University of Louvain (UCLouvain) Louvain Drug Research Institute, supported by Alexandra Degraeve, a UCLouvain FNRS candidate, have been looking into the links between the drug, its dosages, and intestinal microbiota. Their aim has been to determine the factors that influence how the body absorbs and eliminates the drug during transplants. The results of five years of research have been published in Microbiome.

Research using mice

Prof. Bindels began the research using mice, with the goal of determining whether or not the presence of microbiota plays a role in drug absorption. The result was a world first: the UCLouvain researchers observed that without microbiota, tacrolimus levels in the mice’s blood were lower. This means that the presence of microbiota increases the drug’s concentration in the blood, thereby either reducing the risk of transplant rejection or, conversely, increasing the risk of side effects.

The research also uncovered an as yet unknown mechanism: microbiota promote drug absorption by reducing the action of a protein, P-glycoprotein, which acts like a pump on the surface of intestinal cells and limits the absorption of many drugs, including tacrolimus.

Clinical research

At the same time, in collaboration with Profs Michel Mourad and Vincent Haufroid of the UCLouvain Saint-Luc University Hospital, Prof. Elens carried out clinical tests on fecal matter taken from some 100 patients who had undergone kidney transplants. The goal was to understand the reasons for the wide variability in current tacrolimus dosages (from a factor of one to 30) from one patient to another, by revealing the composition of renal transplant patients’ microbiota.

The clinical tests showed that the higher the drug’s dosage, the less rich the microbiota (less diverse in bacteria). The research also identified two specific types of bacteria associated with a reduction in the required dosage of tacrolimus. Finally, tests revealed that patients who developed diabetes after taking tacrolimus routinely showed a reduction in a certain type of bacteria (Anaerostipes) in their microbiota, which could indicate the bacteria protects patients from developing diabetes.

What’s next?

UCLouvain researchers will now study microbiota over a long period, in order to make comparisons before, just after and at intervals from the transplant, and thus gain an even more accurate picture of the interactions between intestinal bacteria and the absorption of certain drugs, such as tacrolimus. The concept is also being applied to other drugs (anti-HIV, hypotensive drugs, etc.) pumped away by P-glycoprotein.

This discovery also demonstrates the importance of better communication between medical specialties: in the future, if a patient who has undergone a kidney transplant is required to take antibiotics (which have a significant impact on microbiota), it would be useful for contact to be made with their nephrologist beforehand in order to minimize side effects or problems of transplant rejection. Similar considerations apply to major dietary changes.

More information:
Laure Bindels et al, Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1, Microbiome (2023). DOI: 10.1186/s40168-023-01578-y

Citation:
Investigating links between tacrolimus dosage and intestinal microbiota to combat organ transplant rejection (2023, July 6)
retrieved 6 July 2023
from https://medicalxpress.com/news/2023-07-links-tacrolimus-dosage-intestinal-microbiota.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-07-links-tacrolimus-dosage-intestinal-microbiota.html

Tags: healthInvestigatingLinks
Previous Post

More IVF babies born after egg collection in summer rather than in autumn, study finds

Next Post

China says 239 people died from COVID-19 in June in a significant uptick

Putin wants to attend 2026 FIFA World Cup in the U.S. “very badly,” Trump says – Axios

Putin Eager to Attend 2026 FIFA World Cup in the U.S., Says Trump

August 23, 2025
How the semiconductor boom and ASU are transforming Arizona’s economy – ASU News

How the semiconductor boom and ASU are transforming Arizona’s economy – ASU News

August 23, 2025
From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

August 23, 2025
Luther College to host discussion exploring links between soil and food health – Luther College

Luther College to host discussion exploring links between soil and food health – Luther College

August 23, 2025
OPINION | WOODY BASSETT: Can the nation do better in its politics? Can the Democrats? – Northwest Arkansas Democrat-Gazette

OPINION | WOODY BASSETT: Can the nation do better in its politics? Can the Democrats? – Northwest Arkansas Democrat-Gazette

August 23, 2025
Crossings: How Road Ecology is Shaping the Future of Our Planet – Living on Earth

Crossings: How Road Ecology is Shaping the Future of Our Planet

August 23, 2025
Toyota Friday Night Rivals kicks off season with Elizabethton at Science Hill – WCYB

Toyota Friday Night Rivals Ignite the Season with Elizabethton vs. Science Hill Showdown

August 23, 2025
Star Trek as Refuge for the Science-Minded – The Provincetown Independent

How Star Trek Ignites Passion and Empowers the Science-Minded

August 23, 2025
Refresh your wardrobe at these 11 QTS award-winning fashion and lifestyle stores – Time Out Worldwide

Transform Your Look with These 11 Must-Visit Fashion and Lifestyle Stores

August 23, 2025
Alcorn State awarded grant to boost STEM with VR technology – WJTV

Alcorn State Secures Grant to Transform STEM Education Through Cutting-Edge VR Technology

August 23, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (785)
  • Economy (806)
  • Entertainment (21,685)
  • General (16,624)
  • Health (9,846)
  • Lifestyle (818)
  • News (22,149)
  • People (807)
  • Politics (815)
  • Science (16,018)
  • Sports (21,304)
  • Technology (15,786)
  • World (787)

Recent News

Putin wants to attend 2026 FIFA World Cup in the U.S. “very badly,” Trump says – Axios

Putin Eager to Attend 2026 FIFA World Cup in the U.S., Says Trump

August 23, 2025
How the semiconductor boom and ASU are transforming Arizona’s economy – ASU News

How the semiconductor boom and ASU are transforming Arizona’s economy – ASU News

August 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version