* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, October 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Is Omitting Radiation Therapy in Low-Risk Breast Cancer a Good IDEA?

December 9, 2023
in Health
Is Omitting Radiation Therapy in Low-Risk Breast Cancer a Good IDEA?
Share on FacebookShare on Twitter

SAN ANTONIO — Postmenopausal women with genomically low-risk early hormone receptor (HR)-positive breast cancer had a low risk of recurrence with endocrine therapy alone after lumpectomy, a randomized trial showed.

The 5-year overall survival (OS) and cancer-specific survival (CSS) rates were 100% without adjuvant radiation therapy (RT) in 186 women ages 50-69 followed for at least 56 months. The 5-year freedom from any recurrence was 99%.

Two patients had recurrences before 5 years, but an additional six patients had later recurrences, although no patient had distant (metastatic) recurrence. Though promising, the results do not mean that women with low-risk HR-positive breast cancer should routinely omit radiation therapy, said Reshma Jagsi, MD, of Emory University and Winship Cancer Institute in Atlanta, during the San Antonio Breast Cancer Symposium (SABCS).

“These findings shouldn’t be generalized to patients who have less extensive surgery [than required in the clinical trial] or who are expected not to be compliant with endocrine therapy,” she said. “The other cautionary note is perhaps even more important to reflect on. Advances in radiation therapy have substantially reduced the toxicity and short-term burden of treatment, even since the initiation of this trial in 2015. The patients eligible for [this trial] can also receive radiation treatment in five fractions or less.”

“The worst thing we can do for our patients is make them think radiation is the ‘Danger. Radiation’ sign because it is harsh and toxic and brutal and awful,” Jagsi continued. “There are many patients who benefit meaningfully from radiation treatment. We don’t want to go too far in overstating the interest in omitting radiation therapy. Of course, we know that some women do wish to avoid the burden and potential toxicity of radiation therapy altogether, even though it is lower than it once was.”

The results were published simultaneously in the Journal of Clinical Oncology.

Unresolved Issues

Similar favorable results with radiotherapy omission came from the LUMINA trial, albeit in a somewhat different patient population, said SABCS invited discussant Andrea Barrio, MD, of Memorial Sloan Kettering Cancer Center in New York City. Both studies sought to determine whether tumor biology can be used to identify patients who might omit radiotherapy, as it has for systemic therapy. Collectively the two studies suggest that “radiotherapy would have a negligible effect in further lowering the risk of local recurrence.”

Differences in the trials’ enrollment criteria and patient populations raised several unresolved issues, said Barrio. What is the ideal surgical margin width? Should lobular and high-grade cancers be included? Should lymphovascular invasion and extensive intraductal component be allowed? What is the preferred assay for determining risk?

“In thinking about application into real-world practice, it is hard enough to convince people to stop irradiating women over 70, but I do hope that we will try to convince some patients or practitioners that we don’t need to irradiate everyone over 50,” said Barrio. “Over 50% of women over 70 receive RT, despite evidence supporting omission. This may be due to endocrine therapy adherence. Over 30% of women discontinue endocrine therapy. That’s not what they saw in these trials, but that’s what we see in the real world.”

A landmark trial published 20 years ago showed that radiation therapy could be safely omitted with reasonable local control in selected patients 70 or older. A second trial published at the same time failed to show a similar positive outcome in women 50 or older. Subsequent long-term follow-up showed that RT could be omitted with reasonable 10-year recurrence rates in selected patients 70 or older and 65 or older.

IDEA Trial

Jagsi reported 5-year findings from the single-arm IDEA trial, involving 200 women ages 50-69 with stage I unicentric HR-positive/HER2-negative breast cancer treated with lumpectomy and 5 years of adjuvant endocrine therapy. All of the patients had an Oncotype DX Recurrence Score (RS) ≤18, indicating a low risk of recurrence. Data analysis was performed 5 years after the last enrolled patient underwent lumpectomy.

The study population had a mean age of 62, mean tumor size of 10 mm, and mean RS of 11. All of the patients were pathologically node negative. Histology was ductal in 85% and lobular in 10%. Grade distribution was grade 1 in 42.5%, grade 2 in 54.5%, and grade 3 in 3%. Lymphovascular invasion was present in 14.5% of cases.

Crude rates of ipsilateral breast events (IBE) for the entire follow-up period were 3.3% (two of 60) among patients ages 50-59 and 3.6% (five of 140) for patients ages 60-69. Crude rates of overall recurrence were 5.0% (three of 60) for patients 50-59 and 3.6% (five of 140) for patients 60-69. Seven of the eight recurrences that occurred over the entire follow-up period were IBEs, and one patient had an IBE with regional recurrence.

Overall, 169 of 200 patients remained compliant with endocrine therapy (received as prescribed 90% of the time), including both patients who recurred before 5 years and three of the six patients who recurred after 5 years, said Jagsi.

Four ongoing randomized trials should provide definitive answers about omitting RT in early breast cancer. One trial involves patients 50 or older, one involves patients 60 or older, one involves patients 70 or older, and the fourth has a study population ≥50 to
>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/sabcs/107769

Tags: healthOmittingradiation
Previous Post

Kidney Disease in Pregnancy Often Overlooked for Care

Next Post

FDA Inspections of Foreign Drug Manufacturers Haven’t Bounced Back After Pandemic

How the gathering of Israel is accelerating around the world – Church News

The Global Gathering of Israel: How It’s Accelerating Like Never Before

October 4, 2025
United States Economic Forecast Q3 2025 – Deloitte

United States Economic Forecast Q3 2025 – Deloitte

October 4, 2025
Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

October 4, 2025
Holding Commercial Health Insurers Accountable – American Hospital Association

Holding Commercial Health Insurers Accountable – American Hospital Association

October 4, 2025
Inside Iowa Politics: Ian Roberts deceived Des Moines School Board, chair says – KTIV

Inside Iowa Politics: Ian Roberts deceived Des Moines School Board, chair says – KTIV

October 4, 2025
‘This is unprecedented:’ Ecology restricts surface water use in the Yakima River Basin – Yakima Herald-Republic

Unprecedented Move: Ecology Imposes New Restrictions on Yakima River Basin Surface Water Use

October 4, 2025
Roane State, TCAT Knoxville mark milestone at new health science campus – Oakridger

Roane State and TCAT Knoxville Celebrate Major Milestone at New Health Science Campus

October 4, 2025
Science Hill blanks Morristown East – Johnson City Press

Science Hill Cruises to a Commanding Shutout Over Morristown East

October 4, 2025
Favorite Halloween candies in Missouri, Oklahoma, Kansas, Arkansas – Yahoo

Discover the Most Beloved Halloween Candies in Missouri, Oklahoma, Kansas, and Arkansas!

October 4, 2025
MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

October 4, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (850)
  • Economy (871)
  • Entertainment (21,745)
  • General (17,402)
  • Health (9,914)
  • Lifestyle (883)
  • News (22,149)
  • People (872)
  • Politics (882)
  • Science (16,081)
  • Sports (21,371)
  • Technology (15,853)
  • World (854)

Recent News

How the gathering of Israel is accelerating around the world – Church News

The Global Gathering of Israel: How It’s Accelerating Like Never Before

October 4, 2025
United States Economic Forecast Q3 2025 – Deloitte

United States Economic Forecast Q3 2025 – Deloitte

October 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version