* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Free Live Entertainment – Fremont Street Experience

    Enjoy Free Live Entertainment on Fremont Street Tonight!

    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

    Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Free Live Entertainment – Fremont Street Experience

    Enjoy Free Live Entertainment on Fremont Street Tonight!

    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

    Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Is Omitting Radiation Therapy in Low-Risk Breast Cancer a Good IDEA?

December 9, 2023
in Health
Is Omitting Radiation Therapy in Low-Risk Breast Cancer a Good IDEA?
Share on FacebookShare on Twitter

SAN ANTONIO — Postmenopausal women with genomically low-risk early hormone receptor (HR)-positive breast cancer had a low risk of recurrence with endocrine therapy alone after lumpectomy, a randomized trial showed.

The 5-year overall survival (OS) and cancer-specific survival (CSS) rates were 100% without adjuvant radiation therapy (RT) in 186 women ages 50-69 followed for at least 56 months. The 5-year freedom from any recurrence was 99%.

Two patients had recurrences before 5 years, but an additional six patients had later recurrences, although no patient had distant (metastatic) recurrence. Though promising, the results do not mean that women with low-risk HR-positive breast cancer should routinely omit radiation therapy, said Reshma Jagsi, MD, of Emory University and Winship Cancer Institute in Atlanta, during the San Antonio Breast Cancer Symposium (SABCS).

“These findings shouldn’t be generalized to patients who have less extensive surgery [than required in the clinical trial] or who are expected not to be compliant with endocrine therapy,” she said. “The other cautionary note is perhaps even more important to reflect on. Advances in radiation therapy have substantially reduced the toxicity and short-term burden of treatment, even since the initiation of this trial in 2015. The patients eligible for [this trial] can also receive radiation treatment in five fractions or less.”

“The worst thing we can do for our patients is make them think radiation is the ‘Danger. Radiation’ sign because it is harsh and toxic and brutal and awful,” Jagsi continued. “There are many patients who benefit meaningfully from radiation treatment. We don’t want to go too far in overstating the interest in omitting radiation therapy. Of course, we know that some women do wish to avoid the burden and potential toxicity of radiation therapy altogether, even though it is lower than it once was.”

The results were published simultaneously in the Journal of Clinical Oncology.

Unresolved Issues

Similar favorable results with radiotherapy omission came from the LUMINA trial, albeit in a somewhat different patient population, said SABCS invited discussant Andrea Barrio, MD, of Memorial Sloan Kettering Cancer Center in New York City. Both studies sought to determine whether tumor biology can be used to identify patients who might omit radiotherapy, as it has for systemic therapy. Collectively the two studies suggest that “radiotherapy would have a negligible effect in further lowering the risk of local recurrence.”

Differences in the trials’ enrollment criteria and patient populations raised several unresolved issues, said Barrio. What is the ideal surgical margin width? Should lobular and high-grade cancers be included? Should lymphovascular invasion and extensive intraductal component be allowed? What is the preferred assay for determining risk?

“In thinking about application into real-world practice, it is hard enough to convince people to stop irradiating women over 70, but I do hope that we will try to convince some patients or practitioners that we don’t need to irradiate everyone over 50,” said Barrio. “Over 50% of women over 70 receive RT, despite evidence supporting omission. This may be due to endocrine therapy adherence. Over 30% of women discontinue endocrine therapy. That’s not what they saw in these trials, but that’s what we see in the real world.”

A landmark trial published 20 years ago showed that radiation therapy could be safely omitted with reasonable local control in selected patients 70 or older. A second trial published at the same time failed to show a similar positive outcome in women 50 or older. Subsequent long-term follow-up showed that RT could be omitted with reasonable 10-year recurrence rates in selected patients 70 or older and 65 or older.

IDEA Trial

Jagsi reported 5-year findings from the single-arm IDEA trial, involving 200 women ages 50-69 with stage I unicentric HR-positive/HER2-negative breast cancer treated with lumpectomy and 5 years of adjuvant endocrine therapy. All of the patients had an Oncotype DX Recurrence Score (RS) ≤18, indicating a low risk of recurrence. Data analysis was performed 5 years after the last enrolled patient underwent lumpectomy.

The study population had a mean age of 62, mean tumor size of 10 mm, and mean RS of 11. All of the patients were pathologically node negative. Histology was ductal in 85% and lobular in 10%. Grade distribution was grade 1 in 42.5%, grade 2 in 54.5%, and grade 3 in 3%. Lymphovascular invasion was present in 14.5% of cases.

Crude rates of ipsilateral breast events (IBE) for the entire follow-up period were 3.3% (two of 60) among patients ages 50-59 and 3.6% (five of 140) for patients ages 60-69. Crude rates of overall recurrence were 5.0% (three of 60) for patients 50-59 and 3.6% (five of 140) for patients 60-69. Seven of the eight recurrences that occurred over the entire follow-up period were IBEs, and one patient had an IBE with regional recurrence.

Overall, 169 of 200 patients remained compliant with endocrine therapy (received as prescribed 90% of the time), including both patients who recurred before 5 years and three of the six patients who recurred after 5 years, said Jagsi.

Four ongoing randomized trials should provide definitive answers about omitting RT in early breast cancer. One trial involves patients 50 or older, one involves patients 60 or older, one involves patients 70 or older, and the fourth has a study population ≥50 to
>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/sabcs/107769

Tags: healthOmittingradiation
Previous Post

Kidney Disease in Pregnancy Often Overlooked for Care

Next Post

FDA Inspections of Foreign Drug Manufacturers Haven’t Bounced Back After Pandemic

TwinEco: A unified framework for dynamic data-driven digital twins in ecology – ScienceDirect.com

TwinEco: Revolutionizing Ecology with Dynamic Data-Driven Digital Twins

October 28, 2025
How to watch Tennessee high school girls soccer: Science Hill vs. Bearden, Oct. 28 – USA TODAY High School Sports

Don’t Miss the Exciting Tennessee High School Girls Soccer Showdown: Science Hill vs. Bearden on Oct. 28!

October 28, 2025
Scientists Just Mapped 2,600 Dreams – And Found Something Shocking – Yahoo

Scientists Map 2,600 Dreams and Uncover a Shocking Secret

October 28, 2025
Cat Learning “How To Get a Boyfriend” From Her Mom Is Adorably Hilarious – Yahoo

Cat’s Hilariously Adorable Journey Learning “How To Get a Boyfriend” From Her Mom

October 28, 2025
Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

Nigeria’s government is using digital technology to repress citizens. A researcher explains how – The Conversation

October 28, 2025
Panthers vs Bills game review: Déjà vu – Yahoo Sports

Panthers vs Bills: A Thrilling Déjà Vu Showdown

October 28, 2025
Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

October 28, 2025
Trump’s ‘golden age’ economic message undercut by his desire for much lower interest rates – which typically signal a weak jobs market – The Conversation

Trump’s ‘Golden Age’ Economy Questioned as Calls for Lower Interest Rates Reveal Job Market Weakness

October 28, 2025
Free Live Entertainment – Fremont Street Experience

Enjoy Free Live Entertainment on Fremont Street Tonight!

October 28, 2025

SGMC Health Launches Lung Nodule Clinic to Advance Early Detection and Treatment of Lung Cancer – SGMC Health

October 28, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (890)
  • Economy (912)
  • Entertainment (21,783)
  • General (17,856)
  • Health (9,953)
  • Lifestyle (925)
  • News (22,149)
  • People (913)
  • Politics (922)
  • Science (16,123)
  • Sports (21,412)
  • Technology (15,892)
  • World (895)

Recent News

TwinEco: A unified framework for dynamic data-driven digital twins in ecology – ScienceDirect.com

TwinEco: Revolutionizing Ecology with Dynamic Data-Driven Digital Twins

October 28, 2025
How to watch Tennessee high school girls soccer: Science Hill vs. Bearden, Oct. 28 – USA TODAY High School Sports

Don’t Miss the Exciting Tennessee High School Girls Soccer Showdown: Science Hill vs. Bearden on Oct. 28!

October 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version