* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, August 3, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Is Primary Tumor Resection Beneficial in Stage IV CRC?

March 7, 2024
in Health
Is Primary Tumor Resection Beneficial in Stage IV CRC?
Share on FacebookShare on Twitter

TOPLINE:

Resecting the primary colon tumor before chemotherapy does not improve overall survival compared with chemotherapy alone in patients with metastatic colon cancer not amenable to curative therapy, new data showed.

METHODOLOGY:

Chemotherapy is the primary treatment in patients with stage IV colorectal cancer (CRC) and unresectable metastases. It’s unclear whether primary tumor resection before chemotherapy prolongs survival.Among 393 patients with stage IV colon cancer and unresectable metastases enrolled in the SYNCHRONOUS and CCRe-IV trials, 187 were randomly allocated to undergo primary tumor resection and 206 to upfront chemotherapy.The chemotherapy regimen was left up to the treating physician. Overall survival was the primary endpoint. Median follow-up time was 36.7 months.

TAKEAWAY:

Median overall survival was 16.7 months with primary tumor resection and 18.6 months with upfront chemotherapy (P=.191).Comparable overall survival between the study groups was further confirmed on multivariate analysis (hazard ratio, 0.944; P=.65) and across all subgroups.Serious adverse events were more common with upfront chemo than surgery (18% vs 10%; P=.027), due mainly to a significantly higher incidence of GI-related events (11% vs 5%; P=.031).Overall, 24% of the primary tumor resection group did not receive any chemotherapy.

IN PRACTICE:

“The results of our study provide compelling data that upfront primary tumor resection in treatment-naive stage IV CRC not amenable for curative treatment does not prolong [overall survival]. A relatively low incidence of serious adverse events in patients with an intact primary tumor together with a considerable number of patients who did not receive any chemotherapy in the primary tumor resection group provides further arguments against resection of the primary tumor in this group of patients,” the authors of the combined analysis concluded.

SOURCE:

The study, with first author Nuh N. Rahbari, MD, University of Ulm, Ulm, Germany, was published online on February 27 in the Journal of Clinical Oncology.

LIMITATIONS:

Neither study completed their planned patient accrual. Although both trials are nearly identical, differences in the individual study cohorts and trial implementation could have introduced bias. Tumor molecular profiling was not performed.

DISCLOSURES:

The study had no commercial funding. Disclosures for authors are available with the original article.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/primary-tumor-resection-beneficial-stage-iv-crc-2024a10004bf

Tags: healthPrimarytumor
Previous Post

Index Estimates Risk for Fall on Ice and Orthopedic Injury

Next Post

Medical malpractice incidents are more severe during daylight saving time, new study finds

Study reveals China’s ecological red lines offer blueprint for biodiversity protection – Phys.org

Study reveals China’s ecological red lines offer blueprint for biodiversity protection – Phys.org

August 3, 2025
What do TSA bag scanners actually see? – Popular Science

What do TSA bag scanners actually see? – Popular Science

August 3, 2025
Why does your mind goes ‘blank’? New brain scans reveal the surprising answer – Live Science

Why does your mind goes ‘blank’? New brain scans reveal the surprising answer – Live Science

August 3, 2025
U.S. POINTER Study shows lifestyle program improves cognition in older adults – University of California – Davis Health

Lifestyle Program Boosts Cognitive Health in Older Adults, New Study Finds

August 3, 2025
World Championships, Day Eight Finals: Kliment Kolesnikov Blazes to Title in 50 Backstroke; Tie for Silver – Swimming World

Kliment Kolesnikov Blazes to Victory in 50 Backstroke as Day Eight of World Championships Ends with a Silver Medal Tie

August 3, 2025
Bond investors warm to risk, with Fed staying put in ‘Goldilocks’ economy – Reuters

Bond Investors Take Bold Steps as Fed Maintains Steady Course in a ‘Goldilocks’ Economy

August 3, 2025
Go-to entertainment: why gaming was made for the toilet – The Guardian

Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

August 3, 2025
Covenant Health offers immunizations, activities for kids at Back to School Bash – KCBD

Covenant Health’s Back to School Bash: A Fun-Filled Immunization and Activities Event for Kids

August 3, 2025
Trump tells Schumer to ‘go to hell’ as Senate heads home after failed attempt to strike deal on nominees – CNN

Trump tells Schumer to ‘go to hell’ as Senate heads home after failed attempt to strike deal on nominees – CNN

August 3, 2025
Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

Microsoft Aims to Broaden Access to OpenAI Technology

August 3, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (752)
  • Economy (777)
  • Entertainment (21,654)
  • General (16,263)
  • Health (9,814)
  • Lifestyle (785)
  • News (22,149)
  • People (777)
  • Politics (786)
  • Science (15,990)
  • Sports (21,272)
  • Technology (15,754)
  • World (758)

Recent News

Study reveals China’s ecological red lines offer blueprint for biodiversity protection – Phys.org

Study reveals China’s ecological red lines offer blueprint for biodiversity protection – Phys.org

August 3, 2025
What do TSA bag scanners actually see? – Popular Science

What do TSA bag scanners actually see? – Popular Science

August 3, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version