* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, June 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

IV Immunoglobulin May Cut Infection Risk of Anti-BCMA Agents for Myeloma

September 30, 2023
in Health
IV Immunoglobulin May Cut Infection Risk of Anti-BCMA Agents for Myeloma
Share on FacebookShare on Twitter

Use of intravenous immunoglobulin (IVIg) may substantially reduce the risk for severe infections in multiple myeloma patients treated with an anti-B-cell maturation antigen (BCMA) bispecific antibody, a small retrospective study suggested.

In 26 patients who achieved clinical responses to an anti-BCMA bispecific antibody, all experienced severe hypogammaglobulinemia, but during periods when patients were being treated with IVIg, the rate of grade 3-5 infections was reduced by 90% (incidence rate ratio 0.10, 95% CI 0.01-0.80, P=0.0307), reported researchers led by Guido Lancman, MD, MSc, of the University of Toronto.

These lower “infection rates during periods of immunoglobulin replacement is further evidence of the impact of severely impaired humoral immunity,” the team wrote in Blood Cancer Discovery. “Pending confirmation in other datasets and ideally in randomized prospective studies, these results provide a strong rationale for primary prophylaxis with IVIg or subcutaneous Ig in these patients.”

“To the best of our knowledge,” the authors said, “this is the first study to comprehensively analyze risk factors and mitigation strategies to prevent infections in myeloma patients receiving anti-BCMA bispecific antibodies.”

Results of the study “reinforce the need for vigilance and appropriate counseling of patients about infection risk with these potent immunotherapies,” observed Alfred L. Garfall, MD, and Edward A. Stadtmauer, MD, both of the University of Pennsylvania in Philadelphia, in an accompanying commentary. In particular, they suggested that the results support universal use of immunoglobulin replacement therapy in relapsed/refractory multiple myeloma patients receiving anti-BCMA bispecific antibody therapy.

Such a small study is not usually the basis for clinical practice recommendations, Garfall and Stadtmauer added, but “the results affirm the impressions of clinicians with experience using these agents in clinical trials as reflected in recent consensus statements that recommend universal use of [immunoglobulin replacement therapy] in these patients.”

Bispecific antibodies targeting BCMA have been increasingly used to treat multiple myeloma, with two — elranatamab (Elrexfio) and teclistamab (Tecvayli) — receiving FDA approval in this space.

However, while these therapies have achieved impressive efficacy in patients with heavily pretreated multiple myeloma, and are generally well tolerated, “infection has now emerged as an important toxicity,” Lancman and colleagues observed.

They noted that some previous research suggests that IVIg can be used to successfully reduce infection rates in multiple myeloma patients with hypogammaglobulinemia and non-progressive disease, as well as in multiple myeloma patients receiving the anti-CD38 monoclonal antibody daratumumab (Darzalex).

The retrospective study by Lancman and co-authors included 37 patients with heavily pretreated multiple myeloma who had received an anti-BCMA bispecific antibody. Median age was 66 years and 62% were female. The median time from initial diagnosis to treatment with the bispecific antibody was 7.4 years. Patients had a median of seven prior lines of therapy, about two-thirds had high-risk cytogenetics, 78% were triple-class refractory, and 24% were penta-drug refractory.

The overall response rate to the bispecific antibody was 70%. At a median follow-up time of 18.6 months, the median progression-free survival was 17.0 months and median overall survival was 26.3 months.

Of the 26 patients who responded to anti-BCMA bispecific antibody therapy and developed severe hypogammaglobulinemia (defined as IgG levels below 200 mg/dL), 92% received IVIg at some point during treatment.

There were a total of 118 infections during follow-up. Infections were most frequently reported in the respiratory tract (58%), followed by the urinary tract and skin (15% each). Most of the infections were either viral (46%) or bacterial (43%), with 11% fungal.

Twenty-six of the infections were grade 3-5 (0.7 per patient-year), and occurred in 15 patients. There were two grade 5 infections, which occurred at 15.1 months (COVID-19) and 17.6 months (sepsis).

Infections occurred in the first month in 27% of patients, including 14% with grade 3-5 infections. Six patients (16%) had co-occurrence of infection in the first month and cytokine release syndrome. The estimated median time to first any-grade infection was 3.8 months, and the estimated median time to first grade 3-5 infection was 18.7 months.

Lancman and colleagues acknowledged that the study was limited by its retrospective nature and relatively small size, as well as by the non-random administration of IVIg (delivered at the individual physician’s discretion).

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

Lancman reported financial relationships with Janssen and Pfizer; co-authors reported multiple relationships with industry.

Garfall reported financial relationships with Janssen, Novartis, CRISPR Therapeutics, Tmunity Therapeutics, MBS, GSK, and Legend Bio; Stadtmauer reported financial relationships with Janssen, Takeda, BMS, AbbVie, and Amgen.

Primary Source

Blood Cancer Discovery

Source Reference: Lancman G, et al “IVIg use associated with ten-fold reduction of serious infections in multiple myeloma patients treated with anti-BCMA bispecific antibodies” Blood Cancer Discov 2023: DOI:10.1158/2643-3230.BCD-23-0049.

Secondary Source

Blood Cancer Discovery

Source Reference: Garfall A, Stadtmauer E “Understanding infection risk with anti-BCMA bispecific antibodies” Blood Cancer Discov 2023; DOI:10.1158/2643-3230.BCD-23-0157.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/myeloma/106567

Tags: healthImmunoglobulininfection
Previous Post

Future Motion Recalls Onewheel Self-Balancing Electric Skateboards Due to Crash Hazard; Four Deaths Reported

Next Post

Low Tidal Volume Compliance Still Lacking in Mechanical Ventilation

Ecological Restoration Service Market to Reach USD 87.9 Bn by 2031, Growing at 9.4% CAGR – openPR.com

Ecological Restoration Service Market Set to Soar to $87.9 Billion by 2031 with a Robust 9.4% Growth Rate!

June 6, 2025
Boise State moves forward with plans for new science building, signaling an investment in STEM majors – The Arbiter | Boise State

Boise State Unveils Ambitious Plans for Cutting-Edge Science Building, Boosting STEM Education!

June 6, 2025
The Science Of De-Extinction Is Providing Hope For Nature’s Future – Forbes

Reviving the Past: How De-Extinction Science Offers New Hope for Our Planet’s Future

June 6, 2025
Cardi B Slams Offset For Allegedly Not Helping With Kids’ Six-Figure Lifestyle – HOT 97

Cardi B Calls Out Offset for Failing to Support Their Kids’ Luxurious Lifestyle!

June 6, 2025
Hollywood legend Tom Cruise becomes record holder for his fiery Mission Impossible stunt – Guinness World Records

Tom Cruise Sets the Bar High with Record-Breaking Fiery Stunt in Mission Impossible!

June 6, 2025
India could become third largest economy in the world this year: Borge Brende – MSN

India Poised to Become the World’s Third Largest Economy This Year!

June 6, 2025
9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

June 6, 2025
Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

June 6, 2025
Graphics: China’s ecological, environmental quality keeps improving steadily – news.cgtn.com

Graphics: China’s ecological, environmental quality keeps improving steadily – news.cgtn.com

June 5, 2025
The Forgotten History (and Slippery Science) of Canola Oil – Eater

The Forgotten History (and Slippery Science) of Canola Oil – Eater

June 5, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (670)
  • Economy (684)
  • Entertainment (21,590)
  • General (15,267)
  • Health (9,725)
  • Lifestyle (687)
  • News (22,149)
  • People (685)
  • Politics (691)
  • Science (15,902)
  • Sports (21,187)
  • Technology (15,669)
  • World (669)

Recent News

Ecological Restoration Service Market to Reach USD 87.9 Bn by 2031, Growing at 9.4% CAGR – openPR.com

Ecological Restoration Service Market Set to Soar to $87.9 Billion by 2031 with a Robust 9.4% Growth Rate!

June 6, 2025
Boise State moves forward with plans for new science building, signaling an investment in STEM majors – The Arbiter | Boise State

Boise State Unveils Ambitious Plans for Cutting-Edge Science Building, Boosting STEM Education!

June 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version