* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, June 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    Fox News Entertainment Newsletter: Celebrities mentioned during Diddy’s high-profile sex trafficking trial – Fox News

    ‘Sinners,’ starring Michael B. Jordan, is now streaming on Prime Video – About Amazon

    Experience the Thrills of ‘Sinners’ Starring Michael B. Jordan – Now Streaming on Prime Video!

    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Domo to Participate in the D.A. Davidson Technology Summit – Business Wire

    Domo Set to Shine at the D.A. Davidson Technology Summit!

    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

JAK Inhibitor Preserves Beta-Cell Function in Early Type 1 Diabetes

December 7, 2023
in Health
JAK Inhibitor Preserves Beta-Cell Function in Early Type 1 Diabetes
Share on FacebookShare on Twitter

A Janus kinase (JAK) inhibitor helped preserve beta-cell function in people with recent-onset type 1 diabetes, the phase II BANDIT trial found.

Meeting the study’s primary endpoint, daily baricitinib (Olumiant) maintained a significantly higher average mixed-meal-stimulated C-peptide level at week 48 compared with placebo (0.65 vs 0.43 nmol/L/min, P=0.001), according to Thomas Kay, MBBS, PhD, of St. Vincent’s Institute of Medical Research in Melbourne, Australia, and colleagues.

Individuals on 4 mg/day baricitinib also required significantly less daily insulin at week 48 than placebo (0.41 vs 0.52 U/kg), the investigators reported in the New England Journal of Medicine.

This shows it’s possible to “arrest the progression of the autoimmune process that destroys insulin-producing beta-cells and retain the body’s ability to produce insulin,” Kay told MedPage Today.

The sooner therapy is initiated after a type 1 diabetes diagnosis, the more likely it will decrease the need for injected insulin, the BANDIT researchers suggested. They noted that the efficacy of baricitinib may also represent a class effect with other JAK inhibitors.

“This is about preserving insulin production rather than better ways of managing without insulin production,” Kay stressed. “Retained insulin production makes achieving good glycemic control easier and may lead to fewer future complications.”

He suggested that baricitinib may also have promise for preventing the onset of type 1 diabetes, though this hasn’t been tested yet.

Acting as a JAK1 and JAK2 inhibitor, baricitinib is already used to treat conditions such as rheumatoid arthritis, severe COVID-19, and alopecia areata. In type 1 diabetes, “inhibitors of the JAK1 and JAK2 isoforms impair cytokine-induced major histocompatibility complex class I expression in cultured islets and islet cells, impair CD8+ T-cell activation, and block the formation of immune synapses between beta-cells and CD8+ T cells to prevent the death of beta-cells,” the researchers explained.

The present trial comes during a recent shift away from type 1 diabetes therapies that solely treat the disease, towards agents that preserve beta-cell functioning. In the PROTECT trial, two 12-day courses of the anti-CD3 antibody teplizumab (Tzield) yielded 59.3% less loss of beta-cell function, with higher stimulated C-peptide levels at week 78 compared with placebo (least-squares mean difference 0.13 pmol/mL, 95% CI 0.09-0.17). This IV biologic was the first FDA approved agent to delay the progression of type 1 diabetes.

Baricitinib and teplizumab “have a broadly similar effect size,” said Kay, though he noted they have not been tested head-to-head. “One difference is the administration of a daily pill compared with a 10- to 14-day IV infusion. Also baricitinib, and related drugs, has been more widely used for many indications and for children down to 2 years.”

Other than their route of administration, the two therapies have different safety profiles, added accompanying editorial author Johnny Ludvigsson, MD, PhD, of Linköping University in Sweden, highlighting that there were no treatment-related serious adverse events with baricitinib. “This treatment has been used for many years as a treatment for juvenile idiopathic arthritis, and the safety profile of JAK inhibitors has been acceptable.”

In BANDIT, the rate of adverse events overall were numerically lower in the baricitinib group than in the placebo group (78% vs 84%, respectively), as were serious adverse events (2% vs 10%). Nearly all events were of the lowest grade. There were two ketoacidosis events in the baricitinib group and three in the placebo group.

“The relatively small number of patients and short duration of the trial limited the ability to identify rare adverse events,” Kay’s group acknowledged.

A total of 91 participants — 60 on baricitinib and 31 on placebo — were included in the BANDIT trial. Children and adults were included (average age 19 years) and all had been diagnosed with type 1 diabetes within the past 100 days. The majority were white and no patients were younger than 10 years, limiting the generalizability of the findings.

Measured by continuous glucose monitoring, the coefficient of variation of the interstitial glucose level at week 48 was 29.6% and 33.8% in the baricitinib and placebo groups, respectively. Baseline HbA1c was slightly lower in the baricitinib group (7% vs 7.5%) and was the same throughout the trial — “a finding that should be expected in a study in which the investigators do their best to provide good clinical care,” said Ludvigsson.

author['full_name']

Kristen Monaco is a senior staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.

Disclosures

The study was supported by JDRF International, JDRF Australia, the Australian Government Department of Health through the Emerging Priorities and Consumer-Driven Research Initiative, the National Health and Medical Research Council of Australia, and St. Vincent’s Institute of Medical Research in Australia.

Kay and Ludvigsson reported no disclosures. A study co-author reported relationships with Eli Lilly, Novo Nordisk, and Sanofi.

Primary Source

New England Journal of Medicine

Source Reference: Waibel M, et al “Baricitinib and β-cell function in patients with new-onset type 1 diabetes” N Engl J Med 2023; DOI: 10.1056/NEJMoa2306691.

Secondary Source

New England Journal of Medicine

Source Reference: Ludvigsson J “Immune interventions at onset of type 1 diabetes — finally, a bit of hope” N Engl J Med 2023; DOI: 10.1056/NEJMe2312091.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/endocrinology/type1diabetes/107714

Tags: healthInhibitorPreserves
Previous Post

Tucatinib Regimen Boosts PFS in Advanced HER2-Positive Breast Cancer

Next Post

Antisense Drug Trial Provides Key Insights About Huntington’s Disease

Ecological Restoration Service Market to Reach USD 87.9 Bn by 2031, Growing at 9.4% CAGR – openPR.com

Ecological Restoration Service Market Set to Soar to $87.9 Billion by 2031 with a Robust 9.4% Growth Rate!

June 6, 2025
Boise State moves forward with plans for new science building, signaling an investment in STEM majors – The Arbiter | Boise State

Boise State Unveils Ambitious Plans for Cutting-Edge Science Building, Boosting STEM Education!

June 6, 2025
The Science Of De-Extinction Is Providing Hope For Nature’s Future – Forbes

Reviving the Past: How De-Extinction Science Offers New Hope for Our Planet’s Future

June 6, 2025
Cardi B Slams Offset For Allegedly Not Helping With Kids’ Six-Figure Lifestyle – HOT 97

Cardi B Calls Out Offset for Failing to Support Their Kids’ Luxurious Lifestyle!

June 6, 2025
Hollywood legend Tom Cruise becomes record holder for his fiery Mission Impossible stunt – Guinness World Records

Tom Cruise Sets the Bar High with Record-Breaking Fiery Stunt in Mission Impossible!

June 6, 2025
India could become third largest economy in the world this year: Borge Brende – MSN

India Poised to Become the World’s Third Largest Economy This Year!

June 6, 2025
9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

June 6, 2025
Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

June 6, 2025
Graphics: China’s ecological, environmental quality keeps improving steadily – news.cgtn.com

Graphics: China’s ecological, environmental quality keeps improving steadily – news.cgtn.com

June 5, 2025
The Forgotten History (and Slippery Science) of Canola Oil – Eater

The Forgotten History (and Slippery Science) of Canola Oil – Eater

June 5, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (670)
  • Economy (684)
  • Entertainment (21,590)
  • General (15,267)
  • Health (9,725)
  • Lifestyle (687)
  • News (22,149)
  • People (685)
  • Politics (691)
  • Science (15,902)
  • Sports (21,187)
  • Technology (15,669)
  • World (669)

Recent News

Ecological Restoration Service Market to Reach USD 87.9 Bn by 2031, Growing at 9.4% CAGR – openPR.com

Ecological Restoration Service Market Set to Soar to $87.9 Billion by 2031 with a Robust 9.4% Growth Rate!

June 6, 2025
Boise State moves forward with plans for new science building, signaling an investment in STEM majors – The Arbiter | Boise State

Boise State Unveils Ambitious Plans for Cutting-Edge Science Building, Boosting STEM Education!

June 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version