* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, July 5, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Kidney disease gene found to also have a protective mutation

October 8, 2023
in Health
Kidney disease gene found to also have a protective mutation
Share on FacebookShare on Twitter

Kidney disease gene found to also have a protective mutation

Visual Abstract. Credit: Journal of the American Society of Nephrology (2023). DOI: 10.1681/ASN.0000000000000219

African Americans have long been known to be at increased risk of kidney disease due to a dangerous genetic mutation that creates a hole in the kidney cells, but Vanderbilt University Medical Center (VUMC) researchers have now discovered a protective genetic mutation that covers the hole to eliminate the risk.

The findings on the apolipoprotein L1 (APOL1) gene, published today in the Journal of the American Society of Nephrology, could have immediate and broad implications for kidney health because people with both the disease-causing and protective mutation are not at increased risk.

“Our team discovered a different protective genetic mutation in APOL1 that counteracts the disease-causing mutation,” said senior author Alexander Bick, MD, Ph.D., assistant professor of Medicine, Division of Genetic Medicine. “We performed experimental studies and found that the harmful mutation creates a hole in kidney cells. Our protective mutation blocks the hole.

“There are medicines in late-stage clinical development that block the APOL1 hole just like our protective mutation does. Our study shows that these targeted personalized medicine drugs are likely to be a successful treatment strategy. Our results also identify a set of patients with both the harmful and protective APOL1 mutation who would not need this treatment,” he said.

The large human genomic study looked at of 150,582 participants with African ancestry from the Million Veteran Program (MVP), BioVU (VUMC’s de-identified DNA databank) and the All of US Research Program, the NIH’s historic effort to collect and study data from 1 million or more people living in the United States to accelerate health research.

“The results of our study have immediate and broad implications for kidney health,” said lead author Adriana Hung, MD, MPH, associate professor of Medicine, Division of Nephrology, and principal investigator for the kidney disease grant for the Million Veteran Program from the Department of Veterans Affairs. “Individuals with African descent and Latinos have a four-fold increase in the risk of progressing to end stage renal failure, which is partially explained by of APOL1 G1/G2 high risk variants.”

“Additionally, kidney donors with APOL1 high risk variants are also at an increased risk of kidney disease, hence reducing the pool of kidney donors. Interventions to decrease these long-standing inequities in kidney health have been desperately needed,” she said.

The authors are now evaluating the role of APOL1 high risk variants in different settings to understand the overall population that will benefit from pharmacologic inhibitors that mimic the genetic mutation by blocking the APOL1 pore formation and ion channel conduction.

“Our study represents an important step forward in precision nephrology,” Hung said. “It is an extraordinary example of how human genomics studies translated into the discovery of new treatments.”

More information:
Adriana M. Hung et al, Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease, Journal of the American Society of Nephrology (2023). DOI: 10.1681/ASN.0000000000000219

Citation:
Kidney disease gene found to also have a protective mutation (2023, October 6)
retrieved 8 October 2023
from https://medicalxpress.com/news/2023-10-kidney-disease-gene-mutation.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-10-kidney-disease-gene-mutation.html

Tags: Diseasehealthkidney
Previous Post

Efgartigimod efficacious, safe for primary immune thrombocytopenia

Next Post

Editorial: Lurbinectedin for neuroendocrine tumors

New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

July 4, 2025
California AG Rob Bonta says online fantasy sports platforms are illegal in the state – KCRA

California AG Rob Bonta Cracks Down, Declares Online Fantasy Sports Platforms Illegal

July 4, 2025
Bridge Point Tacoma permit and settlement – Washington State Department of Ecology (.gov)

Bridge Point Tacoma permit and settlement – Washington State Department of Ecology (.gov)

July 4, 2025
Accelerated data-driven materials science with the Materials Project – Nature

Accelerated data-driven materials science with the Materials Project – Nature

July 4, 2025
Downtown Louisville, Ky., gets new lifestyle hotel – hotelmanagement.net

Downtown Louisville Welcomes Exciting New Lifestyle Hotel

July 4, 2025
Romer: Finding common ground in a divided world – VailDaily.com

Romer: Building Bridges to Unite a Divided World

July 4, 2025
The Republican Budget Bill Is an Economy Killer – Bloomberg.com

The Republican Budget Bill Is an Economy Killer – Bloomberg.com

July 4, 2025
Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

July 4, 2025
Trump says his 6th phone call with Putin this year ‘didn’t make any progress’ – PBS

Trump says his 6th phone call with Putin this year ‘didn’t make any progress’ – PBS

July 4, 2025
Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

July 4, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (705)
  • Economy (731)
  • Entertainment (21,619)
  • General (15,711)
  • Health (9,768)
  • Lifestyle (735)
  • News (22,149)
  • People (731)
  • Politics (738)
  • Science (15,947)
  • Sports (21,229)
  • Technology (15,715)
  • World (711)

Recent News

New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

July 4, 2025
California AG Rob Bonta says online fantasy sports platforms are illegal in the state – KCRA

California AG Rob Bonta Cracks Down, Declares Online Fantasy Sports Platforms Illegal

July 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version