* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, August 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

    ‘The Roses’ review: Olivia Colman, Benedict Cumberbatch sparkle in dark comedy – Yakima Herald-Republic

    The Roses’ Review: Olivia Colman and Benedict Cumberbatch Shine in Dark Comedy Delight

    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Ten upcoming sports stadiums where technology takes to the field – Dezeen

    10 Futuristic Sports Stadiums Revolutionizing the Game with Cutting-Edge Technology

    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

    ‘The Roses’ review: Olivia Colman, Benedict Cumberbatch sparkle in dark comedy – Yakima Herald-Republic

    The Roses’ Review: Olivia Colman and Benedict Cumberbatch Shine in Dark Comedy Delight

    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Ten upcoming sports stadiums where technology takes to the field – Dezeen

    10 Futuristic Sports Stadiums Revolutionizing the Game with Cutting-Edge Technology

    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Lethal effects of mosquito-transmitted virus mediated by cholesterol receptor: Study paves way for vaccine development

July 26, 2023
in Health
Lethal effects of mosquito-transmitted virus mediated by cholesterol receptor: Study paves way for vaccine development
Share on FacebookShare on Twitter

Lethal effects of mosquito-transmitted virus mediated by cholesterol receptor

Lrp1-depleted MEFs are resistant to RVFV infection. Credit: Science Advances (2023). DOI: 10.1126/sciadv.adh2264

A protein responsible for lethal liver disease in mice infected with Rift Valley fever virus (RVFV) has been identified by scientists at the University of Pittsburgh Center for Vaccine Research. These results from new research published in Science Advances lay groundwork for future vaccine development, as scientists are now one step closer to uncovering how RVFV multiplies within the body.

RVFV is a mosquito-transmitted virus found in Africa and known for its ability to infect wide ranges of animals, insects and humans. Although deadly in most animals, RVFV usually causes milder symptoms in humans but can lead to such complications as loss of vision, liver disease and encephalitis. Scientists have yet to create a vaccine or approve any drugs for treatment.

“The way in which viruses like RVFV can infect wide ranges of species is not well-understood,” said Amy Hartman, Ph.D., associate professor of infectious diseases and microbiology at Pitt’s School of Public Health. “If RVFV were to emerge in the U.S., it would be highly concerning due to how fast it can spread. Our ultimate goal is to use this research to create a vaccine for protection.”

The liver is a major site of viral replication for viruses like RVFV. In her previous research, Hartman and her colleagues found that a cholesterol receptor found throughout the body, called low-density lipoprotein receptor-related protein 1 (Lrp1), was responsible for initiating the RVFV infection in animal cells. However, the role of Lrp1 in hepatic disease, as well as how the virus spreads and infects specific groups of cells within a living organism, have remained major unanswered questions until now.

To study the interaction, Hartman and her colleagues at Washington University in St. Louis created mice that lack the Lrp1 receptor. Although Lrp1 could not be removed from the entire body—as doing so would cause immediate death—Hartman and her colleagues removed Lrp1 solely from the liver to see if the mice would still develop lethal hepatic disease if infected with RVFV.

For the liver-specific knockout mice, there was little to no viral replication of RVFV in the liver. These mice also lived twice as long as mice with intact Lrp1 levels in the liver. Although the Lrp1-knockout mice did not contract lethal RVFV hepatic disease, they eventually went on to develop a neurological disease mediated through the Lrp1 in their brains.

“Our results are important because they showed that Lrp1 is responsible for lethal RVFV liver disease in a mouse model,” said Hartman, who is also a member of the Center for Vaccine Research. “We can translate these results—as the liver is also responsible for viral replication in humans—and we now have the capability in future research to dissect how the virus spreads throughout the body.”

Other authors of the study include Madeline Schwarz, Ph.D., Ryan M. Hoehl, Ph.D., Cynthia M. McMillen, Ph.D., Rachael E. Rush Ph.D., Kayleigh A. Connors Ph.D., all of the University of Pittsburgh, Xiaoxia Cui, Ph.D., Safder S. Ganaie, Ph.D., Annie Feng, Ph.D., Griffin Brown, Ph.D., Tenzin Yangdon, Ph.D., J. Michael White, Ph.D., Daisy W. Leung, Ph.D., Takeshi Egawa Ph.D., Gaya K. Amarasinghe, Ph.D., all of Washington University in St. Louis.

More information:
Madeline M. Schwarz et al, Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice, Science Advances (2023). DOI: 10.1126/sciadv.adh2264

Citation:
Lethal effects of mosquito-transmitted virus mediated by cholesterol receptor: Study paves way for vaccine development (2023, July 26)
retrieved 26 July 2023
from https://medicalxpress.com/news/2023-07-lethal-effects-mosquito-transmitted-virus-cholesterol.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-07-lethal-effects-mosquito-transmitted-virus-cholesterol.html

Tags: EffectshealthLethal
Previous Post

53 Athletes Named to Skate Canada’s 2023-2024 NextGen Team

Next Post

Q&A: The case of the missing Lyme vaccine

Ecological Concerns – The Portugal News

Rising Ecological Concerns Threaten Portugal’s Natural Heritage

August 28, 2025
Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

August 28, 2025
Posco student volunteers take science projects abroad – The Korea Herald

Posco Student Volunteers Ignite Curiosity with Science Projects in Communities Abroad

August 28, 2025
Mediterranean diet with lifestyle changes lowers diabetes risk by 31% – News-Medical

Adopting a Mediterranean Diet and Lifestyle Cuts Diabetes Risk by 31%

August 28, 2025
ITSWC 2025: Thursday sessions guide – Traffic Technology Today

Your Ultimate Guide to Thursday Sessions at ITSWC 2025

August 28, 2025
Real Madrid Graduate School Universidad Europea and UNO Launch Dual Degree in Sports Management – University of Nebraska Omaha

Real Madrid Graduate School and UNO Launch Exciting New Dual Degree in Sports Management

August 28, 2025
Hamburg Township baton twirlers capture world championship title in Italy – WXYZ Channel 7

Hamburg Township Baton Twirlers Triumph as World Champions in Italy

August 28, 2025
Diversification helps Minnesota farm navigate ag economy slump – Brownfield Ag News

How Diversification is Powering a Minnesota Farm’s Success During Tough Agricultural Times

August 28, 2025
‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

August 28, 2025
CDC Director Susan Monarez ousted, four other leaders quit health agency – CNBC

Top Health Officials Resign Amid Controversy as CDC Director Susan Monarez Is Ousted

August 28, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (794)
  • Economy (813)
  • Entertainment (21,692)
  • General (16,717)
  • Health (9,854)
  • Lifestyle (827)
  • News (22,149)
  • People (814)
  • Politics (821)
  • Science (16,023)
  • Sports (21,312)
  • Technology (15,794)
  • World (795)

Recent News

Ecological Concerns – The Portugal News

Rising Ecological Concerns Threaten Portugal’s Natural Heritage

August 28, 2025
Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

August 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version