* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Making immunotherapy safe for AML

September 30, 2023
in Health
Making immunotherapy safe for AML
Share on FacebookShare on Twitter

Making immunotherapy safe for AML

In a clever sleight of hand, researchers used base editing to shield healthy blood stem cells from immunotherapy, avoiding toxicity. Credit: Adobe Stock | Illustration: Sebastian Stankiewicz, Boston Children’s Hospital

Acute myeloid leukemia (AML), the second most common leukemia in children, is hard to treat and has a five-year survival rate of just 65 to 70%, according to the American Cancer Society. While immunotherapies like monoclonal antibodies or CAR T-cell therapy are effective for certain blood cancers, they have not been possible in AML because of toxicity concerns. It’s been hard to find targets on leukemia cells that normal blood stem cells don’t share, so immunotherapy runs the risk of harming normal cells.

“The problem is that there are no targets for immunotherapy that are specific for the leukemia,” says Pietro Genovese, Ph.D., a researcher in the Gene Therapy Program at Boston Children’s Hospital and the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. “There’s no way to discriminate between healthy cells and leukemic cells.”

But what if the healthy cells could be shielded to avoid this toxicity? Genovese and his colleagues describe such a strategy in Nature. They envision using it together with bone marrow transplantation for children with refractory or relapsed AML.

“We decided to engineer the stem cells being transplanted to make them invisible to the immunotherapy,” Genovese says.

Eliminating the leukemia, sparing healthy cells

The researchers selected three immunotherapy targets (FLT3, CD123 and KIT), proteins on the surface of leukemia cells that are essential to their survival. They then turned to normal blood stem cells. Using base editing, they swapped in new amino acids in the genes encoding the same proteins. The subtle change made cancer immunotherapies unable to recognize the stem cells—with no effect on the cells’ ability to make blood.

“We found that we could modify the specificity of antibodies for a target by changing a single amino acid in the target,” says Gabriele Casirati, MD, a postdoctoral fellow in Genovese’s lab and first author of the study. “We can completely avoid recognition of the normal cells.”

“Other strategies knock out the immunotherapy targets on the stem cells, but we believe ours is more effective because it preserves the functionality of the edited genes,” adds Genovese.

In a humanized mouse model of AML, the researchers showed that their approach enabled CAR T-cell therapy to eliminate the cancer, with no toxicity to normal blood stem cells—a strong proof-of-concept of its effectiveness and safety.

Pre-treating donor stem cells

Clinically, here’s how it would work. Before patients with AML undergo bone marrow transplant, the donor blood stem cells would be pre-treated with base editing. Once the donor cells have engrafted in the bone marrow, patients would receive immunotherapy, which would kill only the leukemia cells.

“New treatments for children and adults with AML are desperately needed,” says Scott Armstrong, MD, Ph.D., president of Dana-Farber/Boston Children’s. “Novel cellular therapy approaches like this one provide new insight. We look forward to translation of these ideas as soon as possible.”

Genovese, who received the 2020 Emerging Scientist Award from Children’s Cancer Research Fund, thinks the base editing approach could work for other blood cancers and possibly solid tumors that share the same surface proteins. His team has applied for patents on the strategy.

With support from the Leukemia & Lymphoma Society and CURE Childhood Cancer, Genovese hopes to lay the groundwork for a clinical trial. The lab is working to optimize the precision and efficiency of the base editing tools, scale up the gene editing protocol, and fine-tune the manufacturing process for the engineered blood stem cells.

More information:
Gabriele Casirati et al, Epitope editing enables targeted immunotherapy of acute myeloid leukaemia, Nature (2023). DOI: 10.1038/s41586-023-06496-5

Citation:
Making immunotherapy safe for AML (2023, September 30)
retrieved 30 September 2023
from https://medicalxpress.com/news/2023-09-immunotherapy-safe-aml.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-09-immunotherapy-safe-aml.html

Tags: healthImmunotherapyMaking
Previous Post

Stem cell treatment halts MS for some patients

Next Post

Teen boys with high blood pressure face danger decades later

Jacobson earns program’s first medal at U23 World Championships – nmuwildcats.com

Jacobson Makes History with Program’s First Medal at U23 World Championships

October 22, 2025
AHLA: Hotels generate $7B for Denver economy – Hotel Management

Hotels Drive Denver’s Economy to Soar by $7 Billion

October 22, 2025
AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

AMC Launches First New Dolby Experience in Gwinnett Since 2017

October 22, 2025
UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

UCare, other carriers dropping Medicare Advantage Plans, leaving 200K Minnesota seniors without health insurance – CBS News

October 22, 2025
With Israel-Hamas Cease-Fire, Some Pro-Palestinian Protesters Look Back at Their Movement, Ruefully – The New York Times

With Israel-Hamas Cease-Fire, Some Pro-Palestinian Protesters Look Back at Their Movement, Ruefully – The New York Times

October 21, 2025
Fusobacterium nucleatum : ecology, pathogenesis and clinical implications – Nature

Unveiling Fusobacterium nucleatum: Exploring Its Ecology, Disease Connections, and Health Impact

October 21, 2025
Escherichia coli with a 57-codon genetic code – Science | AAAS

Escherichia coli Engineered with a Revolutionary 57-Codon Genetic Code

October 21, 2025
LOCALIZE IT: Over 420 anti-science bills target public health protections in statehouses across US – newspressnow.com

More Than 420 Anti-Science Bills Jeopardize Public Health Across the Nation

October 21, 2025
Halloween not your thing? Here’s when Christmas at the Newport mansions will start. – The Providence Journal

Not a Halloween Fan? Find Out When Christmas Magic Begins at the Newport Mansions!

October 21, 2025
Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

October 21, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (879)
  • Economy (901)
  • Entertainment (21,772)
  • General (17,729)
  • Health (9,942)
  • Lifestyle (913)
  • News (22,149)
  • People (901)
  • Politics (911)
  • Science (16,111)
  • Sports (21,400)
  • Technology (15,880)
  • World (884)

Recent News

Jacobson earns program’s first medal at U23 World Championships – nmuwildcats.com

Jacobson Makes History with Program’s First Medal at U23 World Championships

October 22, 2025
AHLA: Hotels generate $7B for Denver economy – Hotel Management

Hotels Drive Denver’s Economy to Soar by $7 Billion

October 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version