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    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

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    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

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    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

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    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

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    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

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Home Health

Metformin Shows Potential to Prevent Neovascular AMD

January 24, 2024
in Health
Metformin Shows Potential to Prevent Neovascular AMD
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TOPLINE:

People who take the oral biguanide metformin have a 5% lower odds of developing age-related macular degeneration (AMD) than people who do not use the diabetes drug. 

METHODOLOGY:

The study included 86,930 patients aged 55 years or older with newly diagnosed neovascular AMD (nAMD) and 86,918 matched controls.Data came from the Merative Marketscan Research Databases.Researchers used multivariable conditional logistic regression to identify risks for nAMD.The study included a subgroup analysis of 22,117 case patients with diabetes and 21,616 controls with diabetes.

TAKEAWAY:

Any use of metformin reduced the chances of developing nAMD by 5% (odds ratio [OR], 0.95; 95% CI, 0.91-0.98).In the diabetes subgroup, the adjusted odds were reduced by 8% (OR, 0.92).Increased doses of metformin correlated with further reduction of the risk for developing nAMD.In patients with diabetes who did not take insulin, the protective effect was slightly more pronounced, reducing the odds by 9% (OR, 0.91).

IN PRACTICE:

This study is the first case-control analysis to investigate the effect of metformin on the conversion to nAMD and the first to examine the protective effects of metformin dose and various hypoglycemic medications on nAMD, according to the researchers. However, the findings are too preliminary to have practice application, they noted. 

SOURCE:

Dimitra Skondra, MD, PhD, with the University of Chicago Pritzker School of Medicine, is the study’s corresponding author. The study was published in Retina.

LIMITATIONS:

The study used diagnosis and treatment codes, which could not be verified. Claims-based data do not offer insight into appropriateness of care. Data on A1c and use of hypoglycemic medications other than metformin were lacking. The statistically significant OR may not be clinically relevant owing to the large sample size.

DISCLOSURES:

The study authors have no relationships to disclose.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medscape – https://www.medscape.com/viewarticle/metformin-shows-potential-prevent-neovascular-amd-2024a10001q3

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