* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Microbiome insights found in poop help predict infections in liver transplant patients

December 17, 2023
in Health
Microbiome insights found in poop help predict infections in liver transplant patients
Share on FacebookShare on Twitter

liver

Credit: Pixabay/CC0 Public Domain

In a new study, researchers at the University of Chicago were able to predict postoperative infections in liver transplant patients by analyzing molecules in their poop. Their analysis represents a key leap forward in exploring the connection between the gut microbiome—the bacteria that inhabit the human body—and overall health.

“Antibiotic resistance is growing every year and getting worse. Without antibiotics that work, we can’t do things like perform surgeries, protect premature infants or treat cancer,” said Christopher Lehmann, MD, an assistant professor of medicine at UChicago Medicine and lead author on the study. “It turns out the human microbiome, particularly the gut microbiome, has adapted to fight off drug-resistant bacteria over the course of history. We need to try to understand how that works to fight off these drug-resistant infections.”

Liver transplant patients are especially susceptible to drug-resistant infections, so Lehmann and his fellow researchers analyzed fecal samples from over 100 liver transplant patients to see if the microbiome could be influencing their risk of infection.

Healthy versus unhealthy microbiomes

The researchers discovered a wide range of microbiome compositions in different patients.

“A healthy microbiome would be composed of over a trillion bacterial cells, with thousands of unique species—like a diverse rainforest,” explained Lehmann. “Some patients have that entire ecosystem wiped out. They still have over a trillion cells, but there’s only one single bacterial species—usually a bad, drug-resistant one. It would be like clear-cutting the rainforest and planting nothing but a single harmful weed species.”

The researchers found that healthy microbiomes produce several key metabolites, which are molecules made through digestion or other chemical processes inside an organism. These metabolites include short-chain fatty acids, which are beneficial to human hosts, as well as secondary bile acids produced when the bacteria modify human bile acids to fit their own needs.

It turned out that in a diverse microbiome, those needs include fighting off drug-resistant bacteria. Some of the bile acids are highly toxic to bacteria such as vancomycin-resistant Enterococcus (VRE), a type of antibiotic-resistant bacteria that frequently causes infections in patients who’ve undergone surgery, cancer treatment or intensive care.

The predictive power of poop

Next, the researchers examined their data to see if there was a correlation between microbiome composition and postoperative infections.

“It turned out that the amount of drug-resistant pathogens in the microbiome predicted postoperative infections with an accuracy we’d normally be looking for in a clinical test,” Lehmann said.

The team then took it one step further. Rather than sequencing genomes to identify specific bacterial species, they decided to look just at the metabolites in patients’ poop to see if those molecules offered the same predictive value. The metabolites alone allowed them to sort patients into two categories: healthy microbiomes and unhealthy microbiomes. Making the final analytical leap, the scientists found they could use the metabolites to predict whether a patient would get an infection at all.

“We can go straight from metabolites to predicting a clinical outcome,” Lehmann said. “This is important because metabolomic analysis can be performed very quickly, whereas sequencing is relatively slow.”

The analytical algorithm is currently very complicated and would need extensive validation before being used as a diagnostic or predictive test in clinical practice. However, these findings lay the groundwork for future studies that could solidify the connection between infection and metabolites in poop, as well as exploring potential causal relationships.

The next step: fixing microbiomes to prevent infection

“The next step of this course of research will be investigating whether we can use these findings to correct people’s microbiomes,” Lehmann said. Patients who have unhealthy, single-species gut microbiomes and are at high risk of infection could potentially receive healthy gut bacteria from external sources restore production of healthy metabolites, including molecules like the secondary bile acids that can help protect against drug-resistant infections.

In 2023, FDA approved two microbiome restoration products. “Microbiome restoration isn’t in the far-off future; it’s already in the present,” Lehmann said.

UChicago’s Biological Sciences Division already has a biobank containing thousands of bacteria, all of which have been analyzed and categorized based on their genomes and what metabolites they produce. UChicago is building a Good Manufacturing Practices (GMP)-compliant facility that will allow scientists to produce, filter, and freeze-dry key gut bacteria derived from healthy donors and pack them into pharmaceutical-grade capsules that people can take like pills.

“We’ve already made a handful of cocktails of bacteria that are missing from patients who have bad outcomes but present in patients that have good outcomes,” Lehmann said. “Those bacteria can work together to make the metabolites that were missing in patients that got infections, and then they can inhabit the gut and theoretically defend against future negative outcomes.”

In patients who have received broad-spectrum antibiotic treatment, such capsules could be used to repopulate healthy gut bacteria that were wiped out. In patients who are at high risk for drug-resistant bacterial infections, supplementing their microbiome metabolites may be able to provide some protection.

“We’ve been losing the battle against multiple drug-resistant bacteria, so we desperately need more weapons,” Lehmann said. “Understanding the microbiome, testing the microbiome’s health, and restoring the microbiome are all crucial new tools we can add to our arsenal.”

The study, “Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection,” was published in Cell Host & Microbe in December 2023. Co-authors include Nicholas P. Dylla, Matthew Odenwald, Ravi Nayak, Maryam Khalid, Jaye Boissiere, Jackelyn Cantoral, Emerald Adler, Matthew R. Stutz, Mark Dela Cruz, Angelica Moran, Huaiying Lin, Anitha Sundararajan, Ashley M. Sidebottom, Jessica Cleary, Eric G. Pamer, Andrew Aronsohn, John Fung, Talia B. Baker and Aalok Kacha.

More information:
Christopher J. Lehmann et al, Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection, Cell Host & Microbe (2023). DOI: 10.1016/j.chom.2023.11.016

Citation:
Microbiome insights found in poop help predict infections in liver transplant patients (2023, December 16)
retrieved 17 December 2023
from https://medicalxpress.com/news/2023-12-microbiome-insights-poop-infections-liver.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-microbiome-insights-poop-infections-liver.html

Tags: healthInsightsmicrobiome
Previous Post

Metabolic dysfunction-associated fatty liver disease is associated with greater impairment of lung function: Study

Next Post

Biomedical engineers unveil the dynamics of maternal immune responses

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Far Greater Than Local Studies Reveal

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Unveils $50M Autism Data Science Initiative to Unlock Causes and Enhance Outcomes

September 23, 2025
Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

Scientists make incredible discovery that solves dangerous issue with plastic: ‘We can help the world’ – Yahoo

September 23, 2025
10 money lessons Boomers learned young that still shape their life choices – VegOut

10 Powerful Money Lessons Boomers Learned Early That Still Shape Their Lives Today

September 23, 2025
Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

September 23, 2025
Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

September 23, 2025
U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

September 23, 2025
AI Tool Predicts Health Problems in Patients 20 Years Before They Emerge – eWeek

AI Tool Detects Health Issues Two Decades Before Symptoms Appear

September 23, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (833)
  • Economy (853)
  • Entertainment (21,731)
  • General (17,200)
  • Health (9,896)
  • Lifestyle (866)
  • News (22,149)
  • People (856)
  • Politics (863)
  • Science (16,064)
  • Sports (21,353)
  • Technology (15,836)
  • World (837)

Recent News

Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments – Nature

Tropical Biodiversity Loss from Land-Use Change Is Far Greater Than Local Studies Reveal

September 23, 2025
NIH launches $50M Autism Data Science Initiative to unlock causes and improve outcomes – National Institutes of Health (NIH) | (.gov)

NIH Unveils $50M Autism Data Science Initiative to Unlock Causes and Enhance Outcomes

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version